This section provides an overview of 2-isopropyl-4-methylthiazole (tropical thiazole), covering its manufacturing processes and regulatory status, and applications in the food, beverage, flavour, and fragrance industries. Also, please check out the introduction to 2-isopropyl-4-methylthiazole manufacturers, supply chain issues, 2-isopropyl-4-methylthiazole suppliers, and 2-isopropyl-4-methylthiazole prices. Sinofi can help you buy 2-isopropyl-4-methylthiazole at bulk wholesale prices based on FEMA 3555 and CAS 15679-13-7.
Table of Contents
What is 2-Isopropyl-4-Methylthiazole?
2-Isopropyl-4-methylthiazole (tropical thiazole) represents an important building block in the flavour formulation engineer’s palette. It functions primarily as a flavouring agent in the food and beverage industry, where manufacturers incorporate it to achieve roasted, nutty, and meaty flavour profiles. This heterocyclic compound belongs to the thiazole family, characterized by a five-membered ring structure containing both sulfur and nitrogen atoms. 2-Isopropyl-4-methylthiazole features an isopropyl group at the 2-position and a methyl group at the 4-position of the thiazole ring, structural features that contribute significantly to its distinctive sensory profile. According to the U.S. Food and Drug Administration (FDA), 2-isopropyl-4-methylthiazole is approved to be used in the food, flavour, and fragrance industries.
Regulatory Status and Safety
2-Isopropyl-4-methylthiazole has been evaluated for use in food applications by relevant regulatory authorities like JECFA, EFSA, ECHACHEM, NIST, and WHO. The compound appears on the Flavor and Extract Manufacturers Association (FEMA) GRAS list, confirming its generally recognized as safe status when used at appropriate levels in food products. European regulations similarly permit its use as a flavouring substance, subject to maximum use levels defined in relevant legislation. As with all flavour ingredients, proper documentation of specifications, certificates of analysis, and adherence to good manufacturing practices remain essential for regulatory compliance. Material safety data sheets should be consulted for appropriate handling procedures, as the compound requires standard laboratory safety precautions during formulation work. The fragrance standard of tropical thiazole has been set by organizations such as IFRA.
Sensory Characteristics
The sensory profile of 2-isopropyl-4-methylthiazole is dominated by pronounced roasted, nutty, and meaty characteristics. At low concentrations, the compound delivers complex notes reminiscent of roasted nuts, toasted grains, and cooked meats. The aroma has been described as possessing green, earthy undertones with a distinctly savory quality that enhances umami perception. The threshold detection level is remarkably low, typically in the parts-per-billion range, which allows flavour formulators to achieve significant impact with minimal dosage. This potency requires careful handling and precise measurement during formulation work.
CAS No.: 15679-13-7
According to the American Chemical Society, the CAS number of 2-isopropyl-4-methylthiazole is 15679-13-7.
CAS Name: 2-Isopropyl-4-Methylthiazole
Molecular Formula: C7H11NS
Molecular Mass: 141.24
Appearance: Colorless to yellow, clear liquid.
JECFA Number: 1037
Boiling Point: 175.00 °C. @ 760.00 mm Hg
Solubility: Soluble in most organic solvents; Slightly soluble in water.
Other Names:
♦ Thiazole, 4-methyl-2-(1-methylethyl)-
♦ 4-Methyl-2-(1-methylethyl)thiazole
♦ Tropical thiazole
♦ Thiazole, 2-isopropyl-4-methyl-
♦ 4-Methyl-2-propan-2-yl-1,3-thiazole
2-Isopropyl-4-methyl-1,3-thiazole
♦ Peach thiazole
2-Isopropyl-4-Methylthiazole Odor
Odor Description: At 0.1% in dipropylene glycol, green, herbaceous, vegetable, earthy odour.
FEMA Number 3555
According to the Flavour and Extract Manufacturers Association (FEMA), the FEMA number of 2-isopropyl-4-methylthiazole is 3555.
Bulk 2-Isopropyl-4-Methylthiazole Manufacturers
The production of 2-isopropyl-4-methylthiazole represents a specialized segment within the broader flavour and fragrance chemicals market. Top 2-isopropyl-4-methylthiazole manufacturers like Ventos and International Flavors & Fragrances have successfully developed pyrazine, thiazole, pyrrole, furan derivatives, and sulfur compounds in over 200 varieties. China serves as a particularly important production center, hosting multiple aroma chemical manufacturers. The concentration of production in China aligns with broader trends in the flavour and fragrance industry.
Sinofi is a bulk 2-isopropyl-4-methylthiazole manufacturer in China, and we have a manufacturing facility with 2,500 square meters for the production of tropical thiazole and downstream application development for food and beverage manufacturers, flavour compounders, and fragrance houses. We supply high-quality 2-isopropyl-4-methylthiazole at bulk prices and serve the food, beverage, flavour, and fragrance industries in the world.
Manufacturing Process of 2-Isopropyl-4-Methylthiazole
The synthesis of 2-isopropyl-4-methylthiazole can be accomplished through several distinct chemical pathways, although commercial production predominantly employs variations of two main approaches. The most widely utilized synthetic route involves the condensation reaction between an alpha-halo ketone and a thioamide under carefully controlled conditions. Specifically, the reaction between 3-chloro-2-butanone (or 3-bromo-2-butanone) and isobutyramide in the presence of a sulfur source proceeds through a cyclization mechanism to form the desired thiazole ring system. This approach benefits from readily available starting materials and relatively straightforward reaction conditions, making it economically attractive for industrial-scale production. The reaction mechanism proceeds through initial nucleophilic attack of the thioamide on the alpha-carbon of the halo ketone, followed by intramolecular cyclization and elimination of the halide to form the thiazole ring. The sulfur atom from the thioamide functionality becomes incorporated into the heterocyclic structure, while the nitrogen and carbonyl components provide the remaining ring atoms. Careful control of stoichiometry ensures complete conversion while minimizing the formation of undesired byproducts.
An alternative synthetic approach utilizes the Hantzsch thiazole synthesis, which involves the condensation of an alpha-haloketone with thiourea or substituted thioureas.
Bulk 2-Isopropyl-4-Methylthiazole Suppliers
The global supply for 2-isopropyl-4-methylthiazole operates as a specialized segment within the broader flavour chemicals industry, characterized by a limited number of primary producers and a more extensive network of distributors and trading companies. Top 2-isopropyl-4-methylthiazole suppliers like Ventos and International Flavors & Fragrances represent the foundation of the supply chain, maintaining dedicated production facilities and technical expertise for thiazole synthesis. These suppliers typically target large-volume customers, including multinational flavour houses and food ingredient companies requiring consistent quality, comprehensive documentation, and technical support for regulatory compliance.
Sinofi is a bulk 2-isopropyl-4-methylthiazole supplier in China, and we have a warehouse with 1,200 square meters for high-quality tropical thiazole. We sell different grades of 2-isopropyl-4-methylthiazole at wholesale prices to food and beverage manufacturers, flavour compounders, and fragrance houses.
Supply Chain of 2-Isopropyl-4-Methylthiazole
The supply chain for 2-isopropyl-4-methylthiazole exemplifies the complexity inherent in specialty chemical distribution networks. The supply chain operates through several distinct tiers, each contributing specialized capabilities and value to the overall distribution network.
Raw Material Procurement
The supply chain originates with basic petrochemical feedstocks and intermediate chemical compounds. This foundational tier generally involves established chemical companies with integrated production facilities and long-term supply agreements.
Chemical Synthesis and Manufacturing
The manufacturing tier consists of specialized fine chemical and flavour chemical producers who possess the technical expertise and regulatory approvals necessary for food-grade chemical production. These manufacturers operate under stringent quality management systems. The synthesis of 2-isopropyl-4-methylthiazole requires specific process chemistry capabilities and quality control infrastructure to ensure product purity and consistency meet industry standards.
Distribution and Trading
The distribution tier comprises specialized chemical distributors, flavour houses, and trading companies that bridge manufacturers and end users. Major flavour and fragrance companies often maintain their own distribution networks and may purchase 2-isopropyl-4-methylthiazole either as a standalone ingredient or incorporate it into proprietary flavour formulations. Independent distributors serve smaller food manufacturers and regional markets, providing smaller quantities and additional services such as technical support, regulatory documentation, and logistics management.
End-User Industries
The final tier encompasses food and beverage manufacturers, flavour compounders, and fragrance houses that incorporate 2-isopropyl-4-methylthiazole into finished products or intermediate formulations. These organizations range from multinational corporations to small and medium enterprises, each with distinct procurement patterns and technical requirements.
Wholesale and Buy 2-Isopropyl-4-Methylthiazole in Bulk
The wholesale and bulk procurement of 2-isopropyl-4-methylthiazole presents significant opportunities for cost optimization and supply chain enhancement when approached with appropriate diligence and strategic planning. Tropical thiazole buyers who invest effort in understanding product requirements, developing robust supplier relationships, ensuring regulatory compliance, and implementing sound logistics practices position their organizations for sustained competitive advantage.
Quality Standards and Regulatory Compliance
Purchasing managers must maintain vigilant oversight of quality specifications when procuring 2-isopropyl-4-methylthiazole in wholesale quantities. The compound must meet stringent purity standards, typically exceeding ninety-eight percent purity for food-grade applications. Comprehensive certificates of analysis should accompany each shipment, documenting essential parameters including appearance, purity levels, identification through spectroscopic methods, and the absence of heavy metals or other contaminants.
Regulatory compliance represents a non-negotiable aspect of procurement. For applications within the food and beverage sector, the compound must comply with regulations established by relevant authorities such as the Food and Drug Administration in the United States, the European Food Safety Authority, and corresponding agencies in other jurisdictions.
Supplier Evaluation and Selection
The selection of wholesale suppliers demands a comprehensive evaluation across multiple dimensions. Buyers should assess potential partners based on their quality control infrastructure, regulatory compliance history, and technical support services. Suppliers offering detailed product documentation, including safety data sheets and regulatory status reports, demonstrate professional competency and facilitate smoother integration into existing procurement workflows.
As a bulk 2-isopropyl-4-methylthiazole manufacturer and supplier in China, we wholesale tropical thiazole to food and beverage manufacturers, flavour compounders, and fragrance houses. We also supply 2-isopropyl-4-methylthiazole to small customers. Normally, they want to buy tropical thiazole in small quantities. To serve them, we can sell 2-isopropyl-4-methylthiazole at bulk prices and provide a one-stop purchasing service.
2-Isopropyl-4-Methylthiazole Prices (USD/Kg)
Food Grade 2-Isopropyl-4-Methylthiazole Prices (GC Content >=99.0%)
| Volume | Unit Price | Shipment |
| 50g | 58 USD | Express |
| 500g | 294 USD | Express |
| 1Kg | 420 USD/Kg | Express |
| 20Kg | >25% cheaper | Express |
| 100Kg-Above | negotiable | Express / Sea |
The 2-isopropyl-4-methylthiazole pricing reflects the compound’s specialized nature, concentrated supplier base, and value-added positioning within flavour and fragrance applications. Multiple factors, including raw material costs, purity specifications, regional market dynamics, regulatory compliance, and sustainability considerations, collectively shape price formation. Tropical thiazole buyers must consider these interconnected variables when analyzing price trends and developing sourcing strategies.
Furthermore, the above 2-isopropyl-4-methylthiazole price quotations do not include the express shipping fee. The reason is that the shipment cost may exceed the value of the tropical thiazole sample. However, the bulk wholesale prices of 2-isopropyl-4-methylthiazole will be much lower than those of small orders. Please contact us for more details.
2-Isopropyl-4-Methylthiazole Specification
| Appearance: | Colorless to yellow, clear liquid. |
| Odor: | Green, herbaceous, vegetable, earthy odor. |
| Purity (GC) | >=99% |
| Specific Gravity | 0.997-1.007 |
| Refractive Index | 1.480-1.502 |
| Heavy Metal (as Pb, mg/Kg) | <=10.0 |
2-Isopropyl-4-Methylthiazole Uses
2-Isopropyl-4-methylthiazole is recognized for its characteristic nutty, roasted, and earthy aroma profile, often described as having cocoa-like, coffee-like, or hazelnut notes. These sensory attributes make it particularly valuable in applications where complex, warm flavor profiles are desired.
Food and Beverage Applications
The primary commercial use of 2-isopropyl-4-methylthiazole is as a flavouring agent in the food and beverage industry. Its robust aromatic profile makes it an essential ingredient in formulating flavours that seek to replicate or enhance roasted, nutty, or savory characteristics. The compound finds applications in coffee flavourings, where it contributes to the depth and complexity of roasted coffee notes. Similarly, it is employed in chocolate and cocoa flavour systems to enhance the natural roasted characteristics of these products.
In savory applications, tropical thiazole serves as a component in meat flavourings, where it contributes to the roasted and browned notes associated with cooked meat products. It also appears in formulations for baked goods, nuts, and snack foods, where its ability to convey toasted and roasted qualities proves valuable. The compound is typically used at very low concentrations, as its potent aroma means that small amounts can produce significant sensory effects.
Fragrance and Perfumery Uses
Beyond food applications, tropical thiazole has found niche uses in the fragrance industry. While not as common as its food flavouring applications, the compound can contribute warm, earthy, and nutty notes to certain fragrance compositions. These applications are generally more specialized and may appear in masculine fragrances or products designed to evoke natural, woody, or gourmand characteristics.
2-Isopropyl-4-Methylthiazole Benefits
2-Isopropyl-4-methylthiazole stands as a valuable compound in the flavour and fragrance sectors, offering distinct advantages that address critical challenges in product formulation and consumer satisfaction.
Enhanced Sensory Performance and Authenticity
The primary benefit of 2-isopropyl-4-methylthiazole lies in its ability to deliver authentic, complex sensory experiences that resonate with consumer expectations. It provides naturally occurring roasted and nutty characteristics that are difficult to replicate through other means. This authenticity proves particularly valuable as consumers increasingly seek products with genuine taste profiles rather than artificial or one-dimensional flavours.
Cost-Effectiveness and Formulation Efficiency
From an operational perspective, tropical thiazole offers significant economic advantages. It demonstrates remarkable potency, meaning that very small quantities can produce substantial sensory effects. This high impact-to-dosage ratio translates directly into cost savings for manufacturers, as less material is required to achieve desired flavour profiles compared to weaker or less effective alternatives.
2-Isopropyl-4-Methylthiazole Used in Flavour and Fragrance
2-Isopropyl-4-methylthiazole represents one such compound that has earned its position as a reliable tool in creating sophisticated flavour and fragrance systems. It presents a complex aroma profile characterized primarily by nutty, roasted, and cocoa-like notes, with secondary characteristics that can be described as earthy, meaty, and toasted.
Formulation Applications in Food Flavours
In coffee flavour systems, tropical thiazole functions as a critical component for building authentic roasted character. Working concentrations typically range from 0.1 to 5 parts per million in the finished product, depending on the desired intensity and the complexity of the overall flavour system. The compound works synergistically with pyrazines, furans, and other thiazoles commonly found in coffee flavour formulations, contributing to the perception of dark roast character without introducing burnt or acrid notes that can occur when relying too heavily on pyrazine compounds alone.
Chocolate and cocoa applications benefit significantly from the inclusion of this thiazole. When formulating chocolate flavours, particularly for applications in beverages, confectionery coatings, and bakery products, 2-isopropyl-4-methylthiazole enhances the perception of roasted cocoa beans and contributes to the overall richness of the chocolate profile. The compound proves especially valuable in formulations where natural cocoa materials are limited by cost or processing constraints, as it helps bridge the sensory gap between economical formulations and premium full-cocoa systems.
In meat flavour systems, particularly those designed to replicate roasted, grilled, or pan-fried characteristics, tropical thiazole contributes to the Maillard reaction profile that defines cooked meat flavours. The compound works effectively alongside sulfur-containing compounds, aldehydes, and other heterocyclic ingredients to create authentic savory profiles. Typical usage levels in savory systems range from 0.5 to 10 parts per million, with higher concentrations used in applications requiring pronounced roasted character, such as barbecue or grilled meat seasonings.
Nut flavour formulations, particularly those targeting hazelnut, roasted peanut, and roasted almond profiles, benefit from the compound’s inherent nutty characteristics. When combined with appropriate pyrazines, aldehydes, and other supporting notes, tropical thiazole helps create the perception of freshly roasted nuts. This application proves particularly valuable in bakery flavours, confectionery products, and nutritional beverages where nut flavours are desired but actual nut materials present allergen concerns or processing challenges.
Technical Formulation Considerations
Several technical factors merit attention when incorporating 2-isopropyl-4-methylthiazole into flavour systems. It exhibits good solubility in typical flavour solvents, including ethanol, propylene glycol, and triacetin, facilitating its incorporation into both oil-soluble and water-dispersible flavour systems. When working with emulsion-based flavours, the compound partitions favorably into the oil phase, which should be considered when calculating dosage levels for aqueous end applications.
Heat stability represents a critical consideration for many food applications. Tropical thiazole demonstrates reasonable stability under typical pasteurization conditions, though extended exposure to high temperatures above 90 degrees Celsius can result in some degradation. For applications involving retort processing or extended baking at high temperatures, formulators should conduct stability studies and may need to adjust dosage levels to compensate for processing losses. In some cases, encapsulation technologies can provide additional protection during harsh processing conditions.
The compound’s reactivity with other flavour components requires careful consideration during formulation development. While generally stable in well-formulated systems, tropical thiazole can interact with reducing sugars under certain conditions, particularly in high-moisture systems stored at elevated temperatures. These interactions, while typically minimal, should be monitored during accelerated stability testing to ensure consistent sensory performance throughout the product’s intended shelf life.
pH effects on sensory perception represent another important formulation variable. The compound’s aroma character can shift slightly in highly acidic systems compared to neutral pH applications, with acidic conditions tending to sharpen the nutty notes while neutral to slightly alkaline systems emphasize the roasted characteristics. This pH dependency should be considered when formulating for applications with varying acidity levels, such as beverages ranging from neutral dairy systems to acidic carbonated products.
Fragrance Applications and Considerations
While less common than food applications, 2-isopropyl-4-methylthiazole finds selective use in fragrance formulations where warm, nutty, and earthy notes are desired. It contributes an interesting character to masculine fragrances, particularly those with woody, tobacco, or leather facets. Usage concentrations in fragrances are typically higher than in food applications, often ranging from 0.01 to 0.1 percent of the total fragrance composition, though specific dosage depends on the desired intensity and the overall fragrance architecture.
A Peach Essence and Its Preparation Method
Include the following ingredients (Total 100g, unit: g):
Propylene glycol, 90; gamma-decanolide, 2.3; gamma-undecalactone, 1.5; hexyl acetate, 0.34; methyl acetate, 0.5; ethyl valerate, 0.05; ethyl butyrate, 0.22; amyl acetate, 0.04; sweet orange oil, 0.05; lemon oil, 0.05; delta-undecalactone, 0.2; delta-dodecalactone, 1.6g; delta-octalactone, 0.12g; acetaldehyde, 0.55g; leaf alcohol, 0.38g; trans-2-vinyl alcohol, 0.25g; methyl cinnamate, 0.48g; phenylethyl acetate, 0.28g; citronellol, 0. 0.35g; hexanoic acid, 0.45g; 2-methylvaleric acid, 0.25g; thiomenthone, 0.02g; 2-isopropyl-4-methylthiazole, 0.02g.
Add them to a 100mL volumetric flask, seal it tightly, and shake it thoroughly in a thermostatic shaker. The parameters are: 20°C, 30 times/min shaking speed, and 15 minutes. Remove it from the shaker after shaking, then get the final product.
In conclusion, tropical thiazole serves diverse applications across multiple industries, with its dominant role in flavour systems reflecting the compound’s ability to deliver distinctive roasted, nutty, and savory notes essential to authentic food flavours. As a bulk 2-isopropyl-4-methylthiazole manufacturer and supplier in China, we sell different grades of 2-isopropyl-4-methylthiazole at wholesale prices to food and beverage manufacturers, flavour compounders, and fragrance houses in the world.