This section focuses on an overview of 2,5-dimethyl pyrazine as well as its manufacturing processes and uses. Also, please check out the introduction to 2,5-dimethylpyrazine manufacturers, supply chain issues, 2,5-dimethylpyrazine suppliers, and 2,5-dimethylpyrazine prices. Sinofi can help you buy high-quality 2,5-dimethyl pyrazine in bulk for industry applications at wholesale prices based on FEMA 3272 and CAS 123-32-0.
Table of Contents
What is 2,5-Dimethylpyrazine?
2,5-Dimethylpyrazine represents a critical building block in modern flavour chemistry, serving as both a naturally occurring compound and a synthetic flavouring agent. This compound has been identified in numerous food products, including roasted coffee beans, baked goods, grilled meats, toasted nuts, and cocoa products. 2,5-Dimethylpyrazine belongs to the pyrazine family, characterized by its distinctive six-membered ring structure containing two nitrogen atoms in positions 1 and 4, with methyl substituents at positions 2 and 5. It demonstrates excellent stability under normal storage conditions, though exposure to strong oxidizing agents should be avoided. Its solubility characteristics include good miscibility with ethanol and other organic solvents, while showing limited water solubility, which influences its behavior in different food matrices and extraction processes. According to the U.S. Food and Drug Administration (FDA), 2,5-dimethyl pyrazine is approved to be used in the food, flavour, and fragrance industries.
Regulatory Status and Safety Considerations
2,5-Dimethylpyrazine enjoys widespread approval for use in food and beverage applications by international regulatory frameworks like RIFM, ECHACHEM, EFSA, WHO, and JECFA. It appears on the GRAS (Generally Recognized As Safe) list in the United States and holds similar positive listings in the European Union, Japan, and other major markets. Despite its favorable regulatory status, formulators must adhere to good manufacturing practices and respect maximum use levels established for different product categories. The fragrance industry follows standards set by organizations such as IFRA.
Natural Occurrence and Formation
2,5-Dimethylpyrazine occurs naturally through Maillard reaction pathways, forming during the thermal processing of foods containing amino acids and reducing sugars. The formation mechanism involves the cyclization and dehydration of intermediate compounds generated during protein-carbohydrate interactions at elevated temperatures.
Understanding these natural formation pathways enables flavor chemists to predict and control the development of pyrazine compounds during food processing, allowing for optimization of flavor profiles through precise control of time, temperature, and ingredient interactions.
Sensory Characteristics
The sensory profile of 2,5-dimethylpyrazine centers on its distinctive nutty and roasted character, with additional notes described as cocoa-like, biscuity, and slightly sweet. The compound exhibits a relatively low odor threshold, making it effective at low concentrations in flavor formulations. Its taste profile contributes depth and complexity to food products, particularly in applications where roasted or baked characteristics are desired.
The compound demonstrates excellent tenacity, providing lasting flavor impact throughout the consumption experience. This persistence makes it valuable for applications requiring sustained flavor release, such as chewing gum, confectionery products, and long-shelf-life baked goods.
CAS No.: 123-32-0
According to the American Chemical Society, the CAS number of 2,5-dimethylpyrazine is 123-32-0.
CAS Name: 2,5-Dimethyl pyrazine
Molecular Formula: C6H8N2
Molecular Mass: 108.14
Appearance: Colorless to light yellow, clear liquid
Additional Assay Information: Sum of 2,5- and 2,6-isomers
JECFA Number: 766
Boiling Point: 154.00 to 156.00 °C. @ 760.00 mm Hg
Solubility: Completely soluble in alcohol; Insoluble in water at 25°C.
Other Names:
♦ Pyrazine, 2,5-dimethyl-
♦ 2,5-Dimethyl-1,4-diazine
♦ 2,5-Dimethyl pyrazine
♦ 2,5-Dimethylpiazine
♦ 2,5-Dimethylparadiazine
♦ 2,5-Dimethyl-pyrazine
2,5-Dimethylpyrazine Odor
At 0.10 % in dipropylene glycol, cocoa, roasted nuts, roast beef, and woody grass medical.
FEMA Number 3272
According to the Flavor and Extract Manufacturers Association (FEMA), the 2,5-dimethylpyrazine FEMA number is 3272.
Bulk 2,5-Dimethylpyrazine Manufacturers
China dominates global production capacity for bulk 2,5-dimethylpyrazine, with several major chemical manufacturers maintaining dedicated production facilities for pyrazine derivatives. Top 2,5-dimethylpyrazine manufacturers like Givaudan and Sigma Aldrich maintain a significant presence in the specialty chemicals segment, focusing on high-purity grades and custom synthesis capabilities. These facilities typically serve pharmaceutical and high-end flavor applications where stringent quality standards and regulatory compliance are paramount. Chinese 2,5-dimethylpyrazine manufacturers benefit from established supply chains for raw materials, competitive production costs, and proximity to key downstream markets in the Asia-Pacific regions.
Sinofi is a bulk 2,5-dimethylpyrazine manufacturer in China, and we have a manufacturing facility with 2,500 square meters for the production of 2,5-dimethylpyrazine. We supply high-quality 2,5-dimethylpyrazine at bulk prices and serve food, flavour, and fragrance industries worldwide.
Manufacturing Process of 2,5-Dimethylpyrazine
The manufacturing of 2,5-dimethylpyrazine requires a sophisticated understanding of organic chemistry principles, process engineering fundamentals, and quality control methodologies. Successful commercial production balances technical performance requirements with economic considerations while maintaining strict adherence to safety and environmental standards. A method for synthesizing 2,5-dimethylpyrazine comprises the following steps:
- Providing a reaction mixture of propylene oxide, ammonia, and ammonium bicarbonate, and concentrating the mixture at a predetermined temperature to obtain an intermediate product, 1-amino-2-propanol.
- Contacting the intermediate product with a catalyst in a fixed bed at a predetermined temperature for a predetermined time to obtain 2,5-dimethylpyrazine, wherein the catalyst is a Cu-Zn-based catalyst.
Bulk 2,5-Dimethylpyrazine Suppliers
The global supply of 2,5-dimethylpyrazine presents significant opportunities for businesses seeking reliable bulk suppliers. Top 2,5-dimethylpyrazine suppliers like Givaudan and Sigma Aldrich typically offer integrated production capabilities spanning multiple pyrazine derivatives, allowing for operational efficiencies and diversified revenue streams.
Sinofi is a bulk 2,5-dimethylpyrazine supplier in China, and we have a warehouse with 1,200 square meters for high-quality 2,5-dimethylpyrazine. We sell different grades of 2,5-dimethylpyrazine at wholesale prices to food, flavour, and fragrance manufacturers.
Supply Chain of 2,5-Dimethylpyrazine
The 2,5-dimethylpyrazine supply chain demonstrates characteristics typical of specialty chemical markets, with established supplier relationships, quality-focused operations, and regulatory compliance requirements.
Supply Chain Structure
Raw Material Sourcing
The production of 2,5-dimethylpyrazine begins with the procurement of key precursor chemicals, primarily involving nitrogen-containing organic compounds and methylating agents. Raw material suppliers typically include large chemical manufacturers and specialty chemical distributors who maintain consistent quality standards and regulatory compliance. The sourcing strategy often emphasizes supplier diversification to mitigate supply disruptions and maintain competitive pricing.
Manufacturing and Distribution
Production facilities for 2,5-dimethylpyrazine typically operate within larger specialty chemical manufacturing complexes, leveraging shared infrastructure and technical expertise. The manufacturing process requires precise temperature control, specialized reaction vessels, and comprehensive quality control systems to ensure product consistency and regulatory compliance. The distribution phase involves multiple intermediary layers, including chemical distributors, flavor houses, and food ingredient suppliers. Primary distributors typically maintain inventory positions and provide technical support services to downstream customers.
End-User Applications
End users primarily consist of food manufacturers across various segments, including processed foods, snack foods, seasonings, and culinary products. These manufacturers integrate 2,5-dimethylpyrazine into formulations to achieve specific flavor profiles and enhance product appeal. The application process requires technical expertise in flavor chemistry and regulatory compliance knowledge.
Wholesale and Buy 2,5-Dimethylpyrazine in Bulk
Successful wholesale procurement of 2,5-dimethylpyrazine requires a sophisticated understanding of market dynamics, supplier capabilities, and quality requirements. Strategic sourcing approaches that emphasize supplier relationships, quality assurance, and risk management enable organizations to secure reliable supplies while optimizing costs and maintaining operational flexibility. 2,5-dimethylpyrazine buyers should implement robust procurement processes and maintain vigilance regarding market developments. You can ensure a reliable supply while optimizing the total cost of ownership for this essential specialty chemical. Supplier diversification represents a fundamental risk management strategy in this market. Given the limited number of qualified manufacturers, developing relationships with multiple suppliers across different geographical regions helps mitigate supply disruption risks. This approach also provides negotiating leverage and access to competitive pricing structures. Long-term contract negotiations should incorporate flexibility mechanisms to address market volatility while securing favorable pricing terms. Volume commitments can often be leveraged to obtain preferential rates, but these agreements must be balanced against demand forecasting accuracy and inventory carrying costs.
As a bulk manufacturer and supplier of 2,5-dimethylpyrazine in China, we supply high-quality dimethyl pyrazine for food, flavour, fragrance, and cosmetic industries. We also wholesale 2,5-dimethyl pyrazine to small customers. Normally, they want to buy dimethyl pyrazine in small quantities. To serve them, we can wholesale 2,5-dimethylpyrazine at bulk prices and provide a one-stop purchasing service.
2,5-Dimethylpyrazine Prices (USD/Kg)
Food Grade 2,5-Dimethylpyrazine Prices (FCC, GC Content >=99.0%)
| Volume | Unit Price | Shipment |
| 50g | 30 USD | Express |
| 500g | 147 USD | Express |
| 1Kg | 210 USD/Kg | Express |
| 20Kg | >20% cheaper | Express |
| 100Kg-Above | negotiable | Express / Sea |
The 2,5-dimethylpyrazine price market has experienced notable fluctuations in recent years, influenced by various factors. Price volatility in this market is influenced by several factors, including raw material costs, regulatory changes, and shifts in end-market demand. The compound’s production process requires specialized equipment and expertise, limiting the number of qualified suppliers and contributing to price stability compared to more commoditized chemicals. Laboratory-scale pricing currently ranges from $40 per 5 grams for high-purity food-grade 2,5-dimethylpyrazine (99-100% purity) to $600 per kilogram for bulk quantities. These prices reflect the specialized nature of the compound and its stringent quality requirements, particularly for food and pharmaceutical applications. North America and Europe markets demonstrate the highest price points, driven by stringent regulatory requirements, advanced quality standards, and established demand from sophisticated food and pharmaceutical industries. The presence of advanced research facilities and high demand for novel food additives supports premium pricing structures.
Furthermore, the above 2,5-dimethyl pyrazine price quotations do not include the express shipping fee. The reason is that the shipment cost of dimethyl pyrazine may exceed the value of the sample. However, the bulk wholesale prices of 2,5-dimethyl pyrazine will be much lower than those of small orders. Please contact us for more details.
2,5-Dimethylpyrazine Specification
| Appearance: | Colorless to light yellow, clear liquid |
| Odor: | Cocoa, roasted nuts, roast beef |
| Purity (GC) | >=99% |
| Refractive Index (25°C) | 1.497 – 1.503 |
| Arsenic (mg/Kg) | <=3.0 |
| Heavy Metal (Pb, mg/Kg) | <=10.0 |
2,5-Dimethylpyrazine Uses
Food and Beverage Applications
The food and beverage sector represents the largest area of application for 2,5-Dimethylpyrazine. This compound serves as a crucial flavoring agent, particularly valued for its ability to impart roasted, nutty, and cocoa-like notes to various products.
In bakery applications, 2,5-dimethylpyrazine enhances the perception of freshly baked goods, contributing to the desirable crust flavors in bread and the roasted notes in cookies and crackers. Confectionery products benefit from its ability to intensify chocolate and cocoa flavors while adding depth and complexity. The compound finds extensive use in coffee and tea flavorings, where it reinforces the natural roasted characteristics and adds richness to the overall profile. Savory applications represent another significant area of use. Meat flavor systems incorporate 2,5-dimethylpyrazine to enhance grilled, roasted, and cooked meat notes. It contributes to the authentic taste of meat alternatives and plant-based proteins, helping create more convincing substitutes for traditional animal products. Snack seasonings frequently include this compound to deliver roasted, toasted, and nutty characteristics that consumers associate with quality and flavor intensity. The beverage industry employs 2,5-dimethylpyrazine in the formulation of coffee substitutes, cocoa-flavored drinks, and various alcoholic beverages. Its ability to provide depth and complexity to flavor profiles makes it an essential component in creating authentic-tasting products that meet consumer expectations for rich, roasted flavors.
Fragrance and Cosmetics Applications
The fragrance industry has recognized the value of 2,5-dimethylpyrazine in creating complex scent compositions. Perfumers incorporate this compound into formulations to add warm, nutty base notes that complement other fragrance elements. Its relatively low odor threshold means that small quantities can significantly impact the overall scent profile of a product.
In cosmetic formulations, 2,5-dimethylpyrazine serves dual purposes. Beyond its aromatic properties, it can function as a masking agent to neutralize unpleasant odors from other active ingredients in skincare and haircare products. This application has become increasingly important as consumers demand products that combine efficacy with pleasant sensory experiences.
Pharmaceutical and Research Applications
The pharmaceutical industry has investigated 2,5-dimethylpyrazine for various therapeutic applications. Research has explored its potential as a building block in drug synthesis, particularly in developing compounds with antimicrobial and anti-inflammatory properties. While many of these applications remain in the research phase, the compound’s unique structure makes it a valuable starting material for synthesizing more complex pharmaceutical intermediates.
Academic and industrial research laboratories utilize 2,5-dimethylpyrazine as a reference standard in analytical chemistry. Its well-characterized properties make it useful for calibrating instruments and validating analytical methods, particularly in flavor and fragrance analysis.
Agricultural and Pest Management Applications
Recent research has revealed interesting applications for 2,5-dimethylpyrazine in agricultural settings. Studies have shown that certain pyrazine compounds, including 2,5-dimethylpyrazine, can influence insect behavior. This discovery has led to investigations into its potential use as a component in environmentally friendly pest management strategies.
Some agricultural researchers have explored the compound’s role in plant-insect interactions, particularly its presence in certain plants as a natural defense mechanism. This understanding has opened possibilities for developing new approaches to crop protection that work with natural systems rather than against them.
Industrial Chemical Synthesis Applications
In the chemical manufacturing sector, 2,5-dimethylpyrazine serves as an important intermediate in the synthesis of other valuable compounds. Its reactive nitrogen atoms and methyl groups provide multiple sites for chemical modification, making it a versatile building block for creating more complex molecules.
The compound finds application in producing specialty chemicals used in various industries, including advanced materials, electronic components, and specialty coatings. Its stability and reactivity profile make it particularly suitable for reactions requiring mild conditions, which can be advantageous in manufacturing processes where energy efficiency and product quality are paramount.
2,5-Dimethylpyrazine Benefits
Primary Benefits in Food Industry
The primary benefit lies in enhancing the flavor profile of foods by contributing nutty, roasted, and toasted notes that consumers associate with quality and palatability. In coffee production, 2,5-dimethylpyrazine plays a crucial role in developing the complex flavor profile that coffee enthusiasts appreciate. During the roasting process, this compound forms alongside other pyrazines, contributing to the overall sensory experience. Similarly, in chocolate manufacturing, the presence of 2,5-dimethylpyrazine enhances the depth and complexity of cocoa products, particularly in dark chocolate varieties where roasted notes are highly valued. The baking industry also benefits from this compound’s properties. In products such as bread crusts, cookies, and crackers, 2,5-dimethylpyrazine contributes to the appealing aroma and taste that develops during baking. Its formation during the browning process helps create the sensory cues that signal proper cooking and quality to consumers.
Benefits in Flavour Formulation
Beyond its natural occurrence, 2,5-dimethylpyrazine serves as a valuable tool in flavor formulation. This application proves especially valuable in products marketed as having roasted or toasted characteristics, where the compound helps deliver on consumer expectations for flavor intensity and authenticity. The compound also finds application in flavor systems designed for meat alternatives and plant-based proteins.
2,5-Dimethylpyrazine Used in Flavour and Fragrance
2,5-Dimethylpyrazine stands as one of the fundamental heterocyclic compounds in the flavor and fragrance industry, contributing distinctive sensory characteristics that enhance countless consumer products. It plays a crucial role in creating complex flavor profiles that range from nutty and roasted to cocoa-like and earthy notes.
Sensory Profile and Applications
The sensory characteristics of 2,5-dimethylpyrazine encompass a complex range of descriptors. At lower concentrations, it typically presents nutty, roasted, and slightly sweet notes reminiscent of roasted hazelnuts or almonds. As concentration increases, more pronounced cocoa and chocolate-like characteristics emerge, often accompanied by earthy undertones. This concentration-dependent sensory profile allows formulators to fine-tune flavor systems for specific applications.
Formulation Considerations and Synergies
Successful incorporation of 2,5-dimethylpyrazine into flavor systems requires understanding its interactions with other flavor components. The compound demonstrates notable synergistic effects with other pyrazines, particularly 2,5-dimethylpyrazine and 2,6-dimethylpyrazine, creating more complex and rounded flavor profiles. Combinations with furans and thiophenes can enhance roasted and meaty characteristics, while pairing with lactones and esters can create an interesting sweet-savory balance in formulations.
Stability considerations play a crucial role in formulation work. While 2,5-dimethylpyrazine exhibits good thermal stability under normal processing conditions, exposure to strong oxidizing agents or extreme pH conditions can lead to degradation. Encapsulation technologies offer solutions for protecting the compound in challenging applications, ensuring consistent flavor delivery throughout the product’s shelf life. The choice of carrier systems significantly impacts the performance of 2,5-dimethylpyrazine in final applications. Propylene glycol, triacetin, and various oils serve as effective carriers, with selection depending on the specific application requirements. Water-based systems may require additional solubilizers or emulsifiers to ensure proper dispersion and prevent flavor separation during storage.
A Black Truffle Flavouring Essence
Includes the following ingredients (by weight):
caprylic and capric glyceride, 82.9%; propyl mercaptan, 0.2%; dimethyl disulfide, 0.1%; 2,5-dimethylpyrazine, 0.04%; 2,6-dimethylpyrazine, 0.04%; n-hexanol, 0.02%; allyl isothiocyanate, 0.04%; 1-octen-3-ol acetate, 0.1%; 3-octanol, 0.1%; 2,3,5-trimethylpyrazine, 0.04%; phenylacetaldehyde, 0.1%; hexanoic acid, 0.1%; octanoic acid, 0.1%; γ-decanoic acid, 0.04%; phenylethyl isothiocyanate, 0.08%; 1-octen-3-ol, 6%; 3-(methylthio)propyl isothiocyanate, 2%; dimethylthiomethane, 8%
In conclusion, 2,5-dimethylpyrazine exemplifies how a single chemical compound can find diverse applications across multiple industries. From enhancing the flavours we enjoy in foods and beverages to contributing to pharmaceutical research and agricultural innovation, its uses continue to expand as our understanding of its properties deepens. As a bulk 2,5-dimethylpyrazine manufacturer and supplier in China, we sell different grades of 2,5-dimethylpyrazine at wholesale prices to large manufacturers and small customers worldwide.