What are Disodium Ribonucleotides (I+G)?

Disodium ribonucleotides, also known as E635 or I+G, are flavor enhancers widely used in the food industry. It is a common flavor enhancer often used in combination with monosodium glutamate (MSG). This compound is a combination of disodium inosinate (IMP, E631) and disodium guanylate (GMP, E627), creating a synergistic effect that amplifies umami flavors in food products. According to the Food and Agriculture Organization of the United Nations (FAO), disodium ribonucleotides are approved to be used in food.

CAS No.: 80702-47-2

According to the American Chemical Society, the CAS number of disodium ribonucleotides is 80702-47-2.
Chemical Formula: Mixture of C10H11N4Na2O8P (Disodium inosinate) and C10H12N5Na2O8P (Disodium guanylate)

E number: E635

According to the European Food Safety Authority (EFSA), disodium ribonucleotides (I+G) are designated as food additive E635. I+G is a versatile flavor enhancer due to its unique properties.

Bulk Disodium Ribonucleotides (I+G) Manufacturers

Top disodium ribonucleotide manufacturers include some companies in Japan, South Korea, and China. Asian manufacturers dominate the global manufacturing landscape. Most major manufacturers are planning capacity expansions in the following years. Large companies like Ajinomoto operate large-scale fermentation and processing facilities in many countries. Production efficiency varies significantly based on manufacturer sizes and technology levels. These companies typically operate as primary manufacturers, converting raw materials into disodium ribonucleotides through bio-fermentation processes.
Sinofi is a bulk disodium ribonucleotide manufacturer in China, and we have a manufacturing facility with 2,500 square meters for the production of disodium ribonucleotides. We supply high-quality disodium ribonucleotides (I+G) at bulk prices for our clients in the food industry.

Manufacturing Process of Disodium Ribonucleotides (I+G)

The manufacturing process of disodium ribonucleotides involves several steps, from the synthesis of guanosine and inosine to the final crystallization and quality control.

Produce guanosine and inosine through bio-fermentation.
Nucleoside phosphorylase catalyzes guanosine and inosine to produce disodium 5′-guanylate and disodium 5′-inosinate by using guanosine, inosine, and sodium pyrophosphate aqueous solution as substrates.
Concentration and crystallization.
Drying.

Bulk Disodium Ribonucleotides (I+G) Suppliers

Disodium ribonucleotides (I+G) suppliers play crucial roles in ensuring the availability of I+G across the global food industry. Top suppliers like Ajinomoto have an extensive network of international distributors. Most major disodium ribonucleotide suppliers provide value-added services beyond simple distribution. Quality assurance and technical support are crucial components of their service offerings.
Sinofi is a bulk disodium ribonucleotide supplier in China, and we have a warehouse with 1,200 square meters for high-quality disodium ribonucleotide E635. We supply different grades of I+G at wholesale prices to food manufacturers around the world.

Supply Chain of Disodium Ribonucleotides (I+G)

The supply chain of disodium ribonucleotides (I+G) represents a complex global network requiring careful management of raw materials, production processes, and distribution channels.

Raw material sourcing.
Manufacturing through fermentation.
Distribution to large food manufacturers and ingredient distributors.
Final use in food products.

Wholesale and Buy Disodium Ribonucleotides (I+G) in Bulk

Successful buying of disodium ribonucleotides in wholesale requires careful attention to quality, regulatory compliance, and supplier relationships. Current wholesale prices vary by order quantity and product grade. By following proper procurement procedures and maintaining high standards, disodium ribonucleotides buyers can ensure a reliable supply of this important flavor enhancer.
As a bulk disodium ribonucleotides manufacturer and supplier in China, we supply high-quality disodium ribonucleotides E635 to large food manufacturers worldwide. We also wholesale our disodium ribonucleotides to small customers. Normally, they want to buy disodium ribonucleotides in small quantities. To serve them, we can wholesale disodium ribonucleotides at bulk prices and provide a one-stop purchasing service.

Disodium Ribonucleotides (I+G) Prices (USD/Kg)

Food Grade Disodium Ribonucleotides (I+G) Price (Purity: 97.0%–101.0%)

Volume	Unit Price	Shipment
50g	10 USD	Express
500g	28USD	Express
1Kg	40 USD /Kg	Express
20Kg	20% cheaper	Express
100Kg-Above	negotiable	Express / Sea

Disodium ribonucleotides (I+G) prices vary significantly based on grade and quantity. Multiple factors affect the final I+G prices, including raw material costs, shipping rates, and market demand. Shipping costs can add substantially to the final price, especially for smaller orders.
Furthermore, the above price quotations of disodium ribonucleotides, especially for small orders, do not include the express shipping fee. The reason is that the shipment cost of disodium ribonucleotides E635 may exceed the value of the sample. However, the bulk wholesale prices of disodium ribonucleotides will be much lower than those of small orders. Bulk orders exceeding 1000 kg will receive preferential pricing. Please contact us for more details.

Disodium Ribonucleotides (I+G) Uses

Disodium guanylate E627 is widely used in various industries:

Food Industry

Instant noodles
Soups and broths
Savory snacks
Processed meats

Seasonings

Flavor enhancers
Bouillon cubes
Sauce mixes
Condiments

Disodium Ribonucleotides (I+G) Benefits

The primary benefits of using disodium guanylate include:

Flavor Enhancement

Intensifies umami taste。
Reduces salt usage while maintaining flavor。
Creates flavor synergy with MSG。
Improves overall taste profile。

Economic Benefits

Cost-effective flavor enhancement.
Reduces the need for expensive natural ingredients.
Extended shelf life of products.
Lower usage rates compared to single nucleotides.

Technical Advantages

High stability during processing.
Good solubility.
Compatible with most food ingredients.
Heat stable.

Disodium Ribonucleotides (I+G) Used in Food

A Salad Dressing with High Water and Low Oil Content – Formulation by Weigh

Production method:
Add 100-115 parts of clean water into mixing pot 1, start stirring, and continue to add 1.3-1.8 parts of salt, 35-45 parts of white sugar, 10-16 parts of glucose powder, 0.1-03 parts of potassium sorbate, 0.01-0.03 parts of disodium EDTA, 0.02-0.06 parts of I+G, 0.1-0.18 parts of monosodium glutamate, 8-10 parts of egg yolk liquid, 0.024-0.028 parts of β-carotene, stir until completely dissolved, then add 9-13 parts of sorbitol, continue stirring evenly and then stop stirring;
Start stirring the homogenizer, vacuum the mixture in the mixing pot 1 into the homogenizer at an angle of 80-90°, Speed 2000- 2400 rpm, homogenization 80-120s;
Add 100-115 parts of clean water, 7-10 parts of acidic seasoning liquid, 0.2-0.25 parts of lactic acid, and 0.06-0.09 parts of phosphoric acid into the stirring pot 1, stir evenly, all raw materials are completely dissolved, and 2-5 parts of water are left to rinse the bottom of the tank, stir for 1min, disperse evenly, vacuum inhale the homogenizer, angle 80-90°, speed 2800-3200rpm, homogenize for 20-40s, and control the inhalation to be completed within 20-30s;
Add 40-45 parts of soybean oil, 0.6-0.8 parts of xanthan gum, and 0.3-0.6 parts of guar gum into the stirring pot 2, stir for 3min, stop stirring after uniform dispersion, break the vacuum, and then reach vacuum, turn on the homogenizer, While homogenizing, suck the liquid, vacuum suck the oil phase in the stirring pot 2 into the homogenizer at an angle of 30°, and suck it all in 30-40s, the speed of the homogenizer is 3000rpm, and continue homogenizing for 50-60s after suction;
Add 40-45 parts of soybean oil and 16-20 parts of acetylated distarch adipate into stirring pot 2, stir for 5min, stop stirring after mixing and dispersing evenly, no agglomeration, vacuum suck the oil phase in the stirring pot 2 into the homogenizer at an angle of 30°, and suck it all in 90-100s, the speed of the homogenizer is 3000rpm, and continue homogenizing for 300-320s after suction;
Discharge, The temperature of the salad dressing discharge is controlled below 25℃.

In conclusion, disodium ribonucleotides remain a crucial ingredient in the food industry, offering both technical and economic benefits. While facing challenges from clean-label trends, their efficient flavor enhancement properties and established safety profile ensure continued relevance in food processing applications. As a bulk disodium ribonucleotides (I+G) manufacturer and supplier in China, Sinofi sells different grades of disodium ribonucleotides at wholesale prices to large manufacturers and small customers worldwide.