This section focuses on an overview of natamycin powder as well as its manufacturing processes and uses. Also, please check out the introduction to natamycin manufacturers, supply chain issues, natamycin suppliers, and natamycin prices. Sinofi can help you buy high-quality natamycin in bulk for your industry applications at wholesale prices based on E235 and CAS 7681-93-8.

Table of Contents

What is Natamycin?

Natamycin (also known as pimaricin) is a naturally occurring antifungal compound produced by the bacterium Streptomyces natalensis. It is widely used as a food preservative and in pharmaceutical applications. Natamycin belongs to the polyene macrolide class of antimicrobials. According to the U.S. Food and Drug Administration (FDA), natamycin is approved to be used in the food industry. Natamycin has also been evaluated by major regulatory bodies like JECFA, ECHACHEM, EUR-LEX, and WHO.

CAS No.: 7681-93-8

According to the American Chemical Society, the CAS number of natamycin is 7681-93-8.
Molecular Formula: C33H47NO13
Molecular Mass: 665.73
Appearance: White to cream-colored crystalline powder
Solubility: Slightly soluble in water, soluble in glacial acetic acid
Stability: Heat-stable, light-sensitive
Natural Origin: Fermentation product

E number: E235

According to the European Food Safety Authority (EFSA), natamycin is approved to be used as a food additive E235. The additive conforms to the EU specifications.

Bulk Natamycin Manufacturers

The global natamycin production capacity is concentrated among established manufacturers and emerging players who meet stringent regulatory requirements for food and pharmaceutical applications. Leading natamycin manufacturers like DSM-Firmenich have developed proprietary fermentation techniques that have helped optimize production efficiency and product quality. Success in this market increasingly depends on balancing production efficiency, product quality, and innovation while meeting diverse regional requirements and regulatory standards. As the demand for natural food preservatives grows, natamycin manufacturers who can adapt to changing market needs while maintaining competitive advantages will likely see continued success.
Sinofi is a bulk natamycin manufacturer in China, and we have a manufacturing facility with 2,500 square meters for the production of natamycin E235. We supply high-quality natamycin powder at wholesale prices and serve food and pharmaceutical industries worldwide.

Manufacturing Process of Natamycin

The manufacturing of natamycin is a complex process including fermentation and downstream processing.

Fermentation Process

Microorganism Selection

The primary microorganism used for natamycin production is Streptomyces natalensis. Some manufacturers also use related species such as S. chattanoogensis or S. gilvosporeus. The selection of high-yielding strains and their maintenance is crucial for efficient production.

Media Preparation

The fermentation medium typically contains:

Carbon sources: glucose, maltose, or starch.
Nitrogen sources: soybean meal, corn steep liquor, or peptone.
Mineral salts: K₂HPO₄, MgSO₄, NaCl, FeSO₄.
Trace elements: zinc, copper, and manganese salts.
pH adjusters to maintain optimal conditions (pH 6.5-7.0).

Fermentation Conditions

Temperature: 28-30°C
Dissolved oxygen: >30% saturation
Agitation: 200-300 rpm
Duration: 5-7 days
pH control: 6.5-7.0 through automatic addition of acid/base

Downstream Processing

Biomass Separation

Centrifugation or filtration to remove cell mass.
Clarification of the fermentation broth.

Extraction

Solvent extraction using butanol or methanol.
pH adjustment to optimize extraction efficiency.
Multiple extraction stages to improve yield.

Concentration

Vacuum evaporation of organic solvents.
Crystallization of crude natamycin.

Purification Steps

Recrystallization using appropriate solvents.
Ion exchange chromatography for high-purity grades.
Activated carbon treatment for decolorization.

Final Processing

Crystallization under controlled conditions.
Filtration and washing of crystals.
Drying under vacuum at a controlled temperature.

Success depends on maintaining optimal conditions at each stage while ensuring compliance with quality and regulatory requirements. Continuous monitoring and process optimization are essential for efficient production at an industrial scale.

Advanced Fermentation Technologies: Implementation of controlled fermentation processes using advanced bioreactors and monitoring systems.
Quality Control Measures: Integration of sophisticated analytical techniques and quality management systems to ensure consistent product quality.
Sustainability Initiatives: Development of eco-friendly production processes and waste reduction strategies.

Bulk Natamycin Suppliers

The global natamycin supply is evolving with increasing demand and stricter quality requirements. While established natamycin suppliers like DSM maintain leadership in premium markets, emerging suppliers from Asia are gaining market share through competitive pricing and improving quality standards. Natamycin buyers must carefully evaluate suppliers based on their specific requirements, considering factors beyond price, such as quality consistency, regulatory compliance, and technical support capabilities.
Sinofi is a bulk natamycin supplier in China, and we have a warehouse with 1,200 square meters for high-quality natamycin E235. We supply different grades of natamycin powder at bulk prices to food and pharmaceutical manufacturers worldwide.

Supply Chain of Natamycin

The natamycin supply chain represents a complex network of raw material suppliers, manufacturers, distributors, and end-users that ensure the efficient production and distribution of this ingredient. Success depends on the effective management of material, information, and financial flows while maintaining quality and regulatory compliance.

Supply Chain Structure

Raw Material Suppliers

Glucose/maltose suppliers
Nitrogen source providers (soybean meal, corn steep liquor)
Mineral salt suppliers
Solvent suppliers

Manufacturing Organizations

Primary manufacturers
Contract manufacturers
Toll manufacturers

Distribution Network

Primary distributors
Regional wholesalers
Specialized chemical distributors

End Users

Food manufacturers
Pharmaceutical companies
Biotechnology firms
Research institutions
Agricultural product manufacturers

Continuous optimization and risk management strategies are essential for maintaining supply chain efficiency and reliability. Future developments in technology and sustainability will continue to shape the evolution of this critical supply chain.

Wholesale and Buy Natamycin in Bulk

Successful wholesale procurement of natamycin requires a comprehensive understanding of market dynamics, quality requirements, and supplier capabilities. Natamycin buyers should implement effective procurement strategies to balance cost optimization with quality assurance and supply security. Whether you’re a food manufacturer, pharmaceutical company, or distributor, regular market monitoring on natamycin and supplier evaluation can ensure continuous improvement in your procurement process.
As a bulk natamycin manufacturer and supplier in China, we supply high-quality natamycin powder to large food and pharmaceutical manufacturers worldwide. We also wholesale natamycin to small customers. Normally, they want to buy natamycin in small quantities. To serve them, we can wholesale natamycin at bulk prices and provide a one-stop purchasing service.

Natamycin Prices (USD/Kg)

Food Grade Natamycin Price (FCC, Purity>=50%, Carrier: Glucose / Lactose / Sodium Chloride)

Volume	Unit Price	Shipment
50g	17 USD	Express
500g	85 USD	Express
1Kg	122 USD /Kg	Express
20Kg	25% cheaper	Express
100Kg-Above	negotiable	Express / Sea

Natamycin prices remain dynamic, influenced by multiple factors including quality grade, volume, region, and market conditions. Understanding these elements and maintaining current market intelligence is crucial for your optimal procurement strategies. Regular monitoring of natamycin price trends and factors will help you make informed purchasing decisions and achieve cost-effective supply management.
Furthermore, the above natamycin price quotations, especially for small orders, do not include the express shipping fee. This is because the shipment cost of natamycin may exceed the value of the sample. However, bulk wholesale natamycin prices are much lower than those for small orders. Please contact us for more details.

Natamycin Uses

Natamycin (E235) is a widely used preservative in the food and pharmaceutical industries:

Food Preservation

Dairy Products

Cheese (surface treatment)
Yogurt
Processed cheese products
Cheese ripening control

Meat Products

Sausage casings
Cured meats
Surface treatment
Shelf-life extension

Beverages

Wine
Fruit juices
Non-carbonated drinks
Fermented beverages

Pharmaceutical Applications

Eye Infections
Contact Lens Solutions
Skin Treatments
Wound Care

Natamycin Benefits

Human Safety

Natural origin
Minimal absorption
No systemic effects
Well-documented safety
Long history of use
Regulatory approval

Environmental Impact

Biodegradable
Environmentally friendly
No residual effects
Sustainable production
Natural compound
Eco-friendly solution

Antimicrobial Activity

Broad-spectrum antifungal
Specific mode of action
Long-lasting effects
Low resistance potential
Consistent performance
Quality maintenance

Application Benefits

Easy to apply
Cost-effective
Stable compound
Versatile uses
Multiple applications
Quality assurance

Natamycin Used in Food

A Method for Making Raspberry Wine – Formulation by Weight

The method includes the following steps:
Select fresh raspberries, wash them, soak them in salt water for 10 minutes to remove the bitterness, then rinse them and drain the water.

Raw material pretreatment

Mix raspberries, blackberries, wolfberries, mulberries, and blackcurrants and beat them into a slurry; add c composite enzymes for enzymolysis. The composite enzyme addition amount is 0.25% of the weight of the raw material slurry, and the enzymolysis conditions are: enzymolysis at 52°C for 1.8 hours to obtain an enzymolysis solution.

The mass ratio of the raspberries, blackberries, wolfberries, mulberries, and blackcurrants is 11:2:0.8:0.8:0.8, and the raspberries, blackberries, wolfberries, mulberries, and blackcurrants are added with water and then beaten with a pulper to obtain a slurry.
The weight ratio of the fruit to the water is 1:25.
The amount of the composite enzyme added is 0.1-0.3% of the weight of the raw material slurry.
The mass ratio of the composite enzyme is pectinase: cellulase (4:1);
The enzymolysis condition is enzymolysis at 48-58°C for 1.5-2.5 hours.

Preparation of fermentation

Raw materials: Sugar and natamycin are added to the enzymolysis solution, and the amount of sugar added is 250g/L; The amount of natamycin added is 0.15g-0.35g/L; After mixing evenly, the raspberry wine fermentation raw material is obtained.
Fermentation: Saccharomyces cerevisiae is inoculated into the fermentation raw materials for fermentation. The specific conditions of the fermentation are: fermentation at 25°C-35°C for 25- 45 days, preferably at 30°C for 25 days, and after the fermentation is completed, the fermentation liquid is filtered to obtain the raspberry wine.

In conclusion, natamycin’s versatile applications and proven benefits make it an invaluable compound across multiple industries. Its natural origin, safety profile, and effectiveness continue to drive its adoption in new applications. As a bulk natamycin manufacturer and supplier in China, we sell different grades of natamycin at bulk prices to large manufacturers and small customers worldwide.