This section focuses on an overview of neotame powder as well as its manufacturing processes and uses. Also, please check out the introduction to neotame manufacturers, supply chain issues, neotame suppliers, and neotame prices. Sinofi can help you buy the FDA-approved neotame in bulk for your industry applications at wholesale prices based on E961 and CAS 165450-17-9.
Table of Contents
What is Neotame?
Neotame is a non-nutritive, high-intensity artificial sweetener that belongs to the same chemical family as aspartame. It is chemically known as N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester. Neotame is derived from aspartame through the addition of a 3,3-dimethylbutyl group, which significantly enhances its stability and sweetness potency. It is approximately 7,000 to 13,000 times sweeter than sugar on a weight basis and acts as a flavouring agent. Yet it contains no calories. As neotame does not pose any undesirable flavor and adds no calories, it is widely used in food & beverage products. It also has better stability, even in dry conditions, and is more stable in aqueous food solutions. According to the U.S. Food and Drug Administration (FDA), neotame was approved to be used in food in 2002. The European Chemicals Agency (ECHA) approved it in 2010. It showcases functional properties similar to those of advantame, making it suitable for similar applications. High potency is achievable at a competitive cost to sucrose, enabling cost reductions in sweetener blends.
Regulatory Status and Safety Considerations
Neotame is generally recognized as safe (GRAS) for use in food applications within specified concentration limits. Regulatory bodies, including the FDA, Joint FAO/WHO Expert Committee on Food Additives (JECFA), and EUR-Lex, have evaluated neotame and established acceptable use levels.
According to the International Sweeteners Association (ISA), neotame has been approved in more than 35 countries around the world, including the EU, US, Canada, Mexico, Argentina, Brazil, Russia, Australia, China, Philippines, Indonesia, Japan, Nigeria, and South Africa.
Global Regulatory Approvals
- United States: FDA approved (2002)
- European Union: Approved as E961 (2010)
- Australia/New Zealand: Approved by FSANZ
- Canada: Approved by Health Canada
- Japan: Approved by the Ministry of Health, Labour and Welfare
- Over 35 countries have approved neotame for use in foods and beverages
CAS No.: 165450-17-9
According to the American Chemical Society, the CAS number of neotame is 165450-17-9.
CAS Name: Neotame
Molecular Formula: C20H30N2O5
Molecular Mass: 378.46
Solubility: 4,75 % (w/w) at 60 °C in water, soluble in ethanol and ethyl acetate.
Appearance: white to off-white powder
Other Names:
♦ L-Phenylalanine, N-(3,3-dimethylbutyl)-L-α-aspartyl-, 2-methyl ester
♦ L-Phenylalanine, N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-, 1-methyl ester
♦ Neotame
♦ Mirasee
♦ E 961
♦ Mirasee 200
E Number: E961
According to the European Food Safety Authority (EFSA), the neotame E number is E961. In 2007, it was evaluated and approved as a sweetener in foods and beverages. Currently, E961 has been used as a food additive in over 130 countries.
Bulk Neotame Manufacturers
Top neotame manufacturers include some companies in the United States and China. NutraSweet, the first company producing and marketing neotame, can focus on developing new applications of neotame due to its experience and expertise in the sweetener industry. Sinofi is a bulk neotame manufacturer in China, and we have a manufacturing facility with 2,500 square meters for neotame production. We supply high-quality neotame at bulk prices for our clients around the world.
Manufacturing Process of Neotame
Raw Material: 3,3-dimethyl-butyl aldehyde; aspartame; hydrogen.
(1) Adding aspartame and 3,3-dimethyl-butyl aldehyde to an organic solvent in a vacuum state, reacting at the reaction temperature of 20-50 degree Celsius for 5-24 hours, carrying out concentration and separation at 0-50 degree Celsius after reaction is ended, concentrating to obtain white paste, adding deionized water to devitrify, thus obtaining a neotame intermediate; (2) Adding neotame intermediate and an organic solvent to a hydrogenation reactor, introducing hydrogen until the pressure is 0.1-0.5MPa, adding a catalyst, reacting at the temperature of 35-40 degree Celsius for 5-30 hours, filtering and removing the catalyst, concentrating the filtrate and removing an organic solvent, and recrystallizing and purifying by water, methanol or ethanol, so as to obtain the neotame.
Bulk Neotame Suppliers
Neotame suppliers play a key role in ensuring that food manufacturers have a stable availability of high-quality neotame sweetener for their production. Leading suppliers like NutraSweet have solutions offering different grades of neotame products. Sinofi is a bulk neotame supplier in China, and we have a warehouse with 1,200 square meters for food and feed grade neotame. We supply high-quality neotame at wholesale prices to various industries, including food and beverage manufacturers and e-cigarette makers.
Supply Chain of Neotame
The supply chain of neotame includes raw material suppliers, neotame manufacturers, and end-use industries. These raw materials are crucial for the chemical synthesis process that produces neotame. Fluctuations in the availability of raw materials like aspartame can disrupt the supply chain. Changes in the production capacity of upstream manufacturers or shifts in global demand often cause these fluctuations. Changes in consumer preferences, particularly the growing demand for natural and organic sweeteners, can affect the demand for neotame. This requires the supply chain to be flexible and responsive to shifts in the market. Events like the COVID-19 pandemic can disrupt the supply chain, leading to delays or shortages. Companies involved in the neotame supply chain must have contingency plans to mitigate these risks.
Wholesale and Buy Neotame in Bulk
Purchasing neotame in bulk quantities typically results in significant cost savings per unit. Working with established wholesale suppliers often guarantees consistent quality across batches, which is crucial for maintaining product standards. As a bulk neotame manufacturer in China, we supply neotame to large food and feed manufacturers and distributors. We also wholesale our neotame to small customers and sugar-substitute lovers. Normally, they want to buy neotame in small quantities. To serve them, we can wholesale high-quality neotame at bulk prices and provide a one-stop purchasing service according to their requirements.
Neotame Price USD/Kg
Food Grade Neotame Price (>=99% purity)
Volume | Unit Price | Shipment |
50g | 9 USD | Express |
| 500g | 42 USD | Express |
| 1Kg | 60 USD /Kg | Express |
| 20Kg | >30% cheaper | Express |
| 100Kg-Above | negotiable | Express / Sea |
Neotame prices are influenced by several factors, including raw material availability, degree of market monopoly, manufacturers’ production operations, production costs, regulatory changes, and consumer preferences. The market prices of neotame experienced notable fluctuations during the COVID-19 pandemic period due to various supply chain dynamics and industry developments. Furthermore, the above price quotations of neotame, especially for small orders, do not include the shipping fee. The reason is that the express shipment cost of neotame E951 may exceed the value of the sample. However, the bulk wholesale neotame prices will be much lower than those of small orders. Please contact us for more details.
Neotame Uses
According to the Asian Journal of Chemistry report in March 2023, the stability of neotame in solution form is evaluated by exposure to high-temperature short-time (HTST) conditions, i.e., at 80 °C/30 min at pH 3.0-3.5. It is confirmed that there is no loss of neotame under these conditions. According to Anuradha Kumari’s research, even after high-temperature sterilization (121 °C/15 min), 50.50% of neotame remained intact. Consequently, neotame is widely used for food processing in these conditions. Neotame is also stable in acidic pH conditions. Neotame is considerably safer for people with phenylketonuria due to the presence of the 3,3-dimethyl group, which positively impacts market growth.
Neotame Used in Beverages
A Concentrated Syrup for Beverages – Formulation by Weight
HFCS 55, 680-894 parts; Mixed syrup, 150-279.3 parts; 75% Maltose syrup, 0-100 parts; 1% Aspartame, 1.12-1.95; 5% Sucralose, 0-0.85 parts; 5% Acesulfame K, 0.65-0.85 parts; 1% Neotame, 0-0.6 parts; and 5% Sodium cyclamate, 0-0.55 parts.
Neotame Used in E-Liquid
A Mango-Flavored E-cigarette Oil – Formulation by Weight
Mango flavor, 20; 1,2-Propanediol, 50; Glycerol, 12; Xylitol, 4; Citric acid, 0 .6; Malic acid, 1.4; Honeysuckle extract, 6; Neotame, 3; Menthol, 0 .8; Cooling agent WS-3, 2; Cooling agent WS-23, 4.
Neotame Used in Feed
A Feed Sweetener for Intestinal Health of Animals – Formulation by Weight
Sodium saccharin anhydrous, 30-35 parts; Neotame, 1-2 parts; Neohesperidin dihydrochalcone, 1-3 parts; Stevia, 2-3 parts; Sodium cyclamate, 3-5 parts; Mogroside V, 0.5-2 parts; Citric acid, 8-12 parts; Flavor enhancer, 10-13 parts; Fermented herbal medicine, 18-21 parts; Carrier, appropriate amount; The flavor enhancer is selected from one or more of ethyl maltol, ethyl vanillin, disodium 5′-guanosinate, disodium 5′-inosinate, and sodium citrate.
In conclusion, neotame uses are vast and varied, touching many aspects of our lives. As a bulk neotame manufacturer and supplier in China, we sell FDA-approved neotame at wholesale prices to large food, flavour, E-cigarette, and feed manufacturers and small customers around the world.