This section focuses on an overview of Rebaudioside M (Reb M, E960c) as well as its manufacturing processes and uses. Also, please check out the introduction to Rebaudioside M manufacturers, supply chain issues, Rebaudioside M suppliers, and Rebaudioside M prices. Sinofi can help you buy high-quality Rebaudioside M in bulk for your industry applications at wholesale Reb M prices based on CAS 1220616-44-3.
Table of Contents
What is Rebaudioside M (Reb M)?
Rebaudioside M, also known as Reb M, is a high-intensity sweetener derived from the Stevia Rebaudiana plant. It is one of several steviol glycosides found in stevia leaves, known for its sweetness. According to Pubchem, Reb M is a rebaudioside that is rebaudioside A in which the hydroxy groups at positions 2 and 3 of the beta-D-glucosyl ester moiety have both been converted to the corresponding beta-D-glucoside. It offers a clean, sugar-like sweetness without the bitter aftertaste associated with earlier stevia extracts. Rebaudioside M is approved to be used in food in terms of the GRAS Notice No. 759 and No. 667. Rebaudioside M 95% is approximately 300 times sweeter than sucrose (table sugar), making it an attractive natural alternative to artificial sweeteners in various food and beverage applications. Rebaudioside M has also been evaluated by relevant regulatory authorities like FAO and EUR-Lex.

CAS No.: 1220616-44-3
According to the American Chemical Society, the CAS number of Rebaudioside M is 1220616-44-3.
Molecular Formula: C56H90O33
Molecular Mass: 1291.29
E Number: E960c
According to the EFSA and Commission Regulation (EU) 2022/1922, Rebaudioside M, produced via enzyme modification, can be called (E960c (I)), which is obtained via enzymatic bioconversion of purified steviol glycoside leaf extracts of the Stevia Rebaudiana Bertoni plant.
FEMA Number 4895 or 4922
According to the Flavor and Extract Manufacturers Association (FEMA), the numbers of normal grade rebaudioside M and high purity rebaudioside M (95%) are FEMA 4895 and FEMA 4922, respectively.
Bulk Rebaudioside M Manufacturers
Top rebaudioside M manufacturers include some companies from the United States, the United Kingdom, and China. These companies often supply Rebaudioside M to food and beverage manufacturers globally. Some large players collaborate with biotechnological companies like Amyris to produce Rebaudioside M through fermentation.
Sinofi is a bulk Rebaudioside M manufacturer in China, and we have a manufacturing facility with 2,500 square meters for the production of Rebaudioside M. We supply high-quality Reb M at wholesale prices for our clients around the world.
Manufacturing Process of Rebaudioside M (Reb M)
The production of Rebaudioside M typically involves the following steps:
- Extraction: Stevia leaves are harvested and undergo a water extraction process.
- Purification: The extract is purified using various techniques such as ultrafiltration and chromatography.
- Conversion: Some manufacturers use enzymatic processes to convert other steviol glycosides (like Reb A) into Reb M, improving yield.
- Crystallization: The purified Reb M is crystallized to obtain the final product.
- Drying and Packaging: The crystals are dried and packaged for distribution.
Some companies have developed proprietary bioconversion processes to produce Reb M more efficiently, often using genetically modified yeast strains.
Bulk Rebaudioside M Suppliers
Rebaudioside M suppliers are key players in driving the growth and adoption of Rebaudioside M as a natural sweetener alternative. Some large Rebaudioside M manufacturers like Ingredion are vertically integrated, handling multiple or all steps of the Reb M supply chain, while others focus on specific parts of the chain or form partnerships to cover the entire process. Sinofi is a bulk Rebaudioside M supplier in China, and we have a warehouse with 1,200 square meters for food-grade Rebaudioside M. We supply high-quality Rebaudioside M at wholesale prices to various industries, including food and beverage manufacturers and flavor companies.
Supply Chain of Rebaudioside M (Reb M)
The Rebaudioside M market has been dynamic, with new technologies and partnerships potentially shifting roles and market positions. The Rebaudioside M supply chain typically includes:
- Stevia Farmers: Primarily located in countries like China, Paraguay, and Kenya.
- Extraction Facilities: Often located near farming areas to process fresh leaves.
- Refinement and Conversion Plants: Where the extract is purified and potentially converted to Reb M.
- Distributors: Companies that market and sell Reb M to food and beverage manufacturers.
- End-Product Manufacturers: Food and beverage companies that incorporate Reb M into their products.
The Rebaudioside M market has been dynamic, with new technologies and partnerships potentially shifting roles and market positions. As production techniques improve and costs decrease, Reb M is poised to become a leading natural sweetener in the global market. Its potential for reducing sugar content in various products makes it an attractive option for manufacturers looking to meet consumer demands for healthier alternatives.
Wholesale and Buy Rebaudioside M in Bulk
The growing demand for Rebaudioside M has led to increased availability in the wholesale market. Food and beverage manufacturers can now purchase Reb M in bulk from various suppliers. When you are buying wholesale, you should verify the purity and quality of the Reb M and consider the extraction method used.
As a bulk Rebaudioside M manufacturer and supplier in China, we not only supply high-quality Reb M to large food manufacturers and distributors worldwide. We also wholesale our Rebaudioside M to small customers and sugar-substitute lovers. Normally, they want to buy Rebaudioside M in small quantities. To serve them, we can wholesale Rebaudioside M at bulk prices and provide a one-stop purchasing service in terms of their requirements.
Rebaudioside M Price (USD/Kg)
Food Grade Rebaudioside M Price (Reb M, purity >=95%)
| Volume | Unit Price | Shipment |
| 50g | 25 USD | Express |
| 500g | 125 USD | Express |
| 1Kg | 180 USD /Kg | Express |
| 20Kg | >=30% cheaper | Express |
| 100Kg-Above | negotiable | Express / Sea |
Rebaudioside M prices command a premium price in the natural sweetener market, but its unique properties often justify the investment for many food and beverage manufacturers. Careful consideration of shipping options and total landed costs is essential for businesses looking to incorporate this innovative ingredient into their products. Furthermore, the above price quotations of Rebaudioside M, especially for small orders, do not include the express shipping fee. The reason is that the shipment cost of Rebaudioside M E960c may exceed the value of the sample. However, the bulk Rebaudioside M prices will be much lower than those of small orders. Please contact us for more details.
Rebaudioside M Uses
Rebaudioside M is widely used in a variety of applications, including:
- Beverages: Soft drinks, flavored waters, sports drinks, and teas.
- Dairy Products: Yogurts, flavored milk, and ice cream.
- Baked Goods: Cookies, cakes, and pastries.
- Confectionery: Candies and chocolates.
- Table-Top Sweeteners: As a sugar substitute for home use.
- Pharmaceuticals: In some medicinal syrups and tablets.
Rebaudioside M continues to gain popularity in the food and beverage industry as manufacturers seek natural, low-calorie sweetening solutions to meet consumer demands for healthier products.
Rebaudioside M Benefits
The primary benefits of Rebaudioside M E960c include:
- Zero-Calorie: It doesn’t contribute calories, aiding in sugar and calorie reduction efforts.
- Natural Origin: Derived from plants, appealing to consumers seeking natural ingredients.
- Minimal Aftertaste: Compared to other steviol glycosides, Reb M has a cleaner taste profile with less bitterness.
- Heat Stable: Suitable for use in baked goods and other heated applications.
- pH Stable: Can be used in a wide range of acidic and neutral products.
- Synergistic Effects: Often used in blends with other sweeteners to optimize taste and cost.
- Regulatory Approval: Recognized as safe by major food safety authorities worldwide.
Rebaudioside M (Reb M) Used in E-Cigarette Liquid
A Sweetening Composition for E-Cigarette Liquid – Formulation by Weight
It can effectively solve the technical problem that sweeteners become bitter and sticky when used in electronic cigarettes.
A sweetening composition includes: Sucralose, 6 parts; Neotame, 10 parts; Rebaudioside A, 8 parts; Rebaudioside M, 4 parts; Advantame, 1 part; Propylene glycol, 71 parts.
The preparation method comprises the following steps:
Step 1. Mix sucralose, neotame, rebaudioside A, rebaudioside M, and advantame, and then perform airflow ultrafine grinding to obtain a mixed powder;
Step 2. Preheat the solvent propylene glycol to 40-60°C, add the mixed powder while shearing and dispersing at 8000-16000 rpm for 40-50 minutes to obtain a mixed solution.
Step 3. After the mixed solution is allowed to stand for 4-6 hours, it is filtered with a filter having a filter diameter of 10-20 μm to obtain a sweetening composition.
Typical e-cigarette liquid formula:
Sweet flavor composition, 2 parts; strawberry flavor, 18 parts; propylene glycol, 40 parts; glycerol, 40 parts;
In conclusion, Rebaudioside M (Reb M) has gained attention for its superior taste profile and potential for widespread application in the food and beverage industry. As a bulk Rebaudioside M manufacturer and supplier in China, Sinofi sells high-quality Reb M at wholesale prices to large food manufacturers and small customers worldwide.





