This section focuses on an overview of L-monomenthyl glutarate as well as its manufacturing process and uses. Also, please check out the introduction to monomenthyl glutarate manufacturers, supply chain issues, monomenthyl glutarate suppliers, and monomenthyl glutarate prices. Sinofi can help you buy high-quality L-monomenthyl glutarate in bulk for your industry applications at wholesale prices based on FEMA 4006 and CAS 220621-22-7.
Table of Contents
What is L-Monomenthyl Glutarate?
L-Monomenthyl glutarate is an ester compound derived from L-menthol and glutaric acid. This cooling agent has gained significant attention in the pharmaceutical, cosmetic, and food industries due to its unique properties and versatile applications. L-Monomenthyl glutarate features the characteristic cyclohexane ring structure of menthol connected to a glutarate moiety. This chemical structure provides the compound with its distinctive cooling effect without the minty flavor typically associated with menthol itself. According to the U.S. Food and Drug Administration (FDA), L-monomenthyl glutarate is approved to be used in the food, flavour and fragrance, cosmetics, and pharmaceutical industries. It has also been evaluated by relevant regulatory authorities like JECFA, EUR-Lex, ECHACHEM, EFSA, and WHO. The IFRA Transparency List provides a guideline to ensure the use of monomenthyl glutarate in food, flavor and fragrance, pharmaceutical, and cosmetic industries.
Advantages Over Traditional Cooling Agents
Compared to menthol and other traditional cooling agents, L-monomenthyl glutarate offers several advantages:
- Reduced sensory irritation
- More controlled cooling profile
- Better stability in various formulations
- Lower volatility
- Minimal impact on product flavor
CAS No.: 220621-22-7
According to the American Chemical Society, the CAS number of L-monomenthyl glutarate is 220621-22-7.
CAS Name: Ultracool 2
Molecular Formula: C15H26O4
Molecular Mass: 270.37
Appearance: Colorless to pale yellow liquid
Boiling Point: 301.00 to 306.00 °C. @ 760.00 mm Hg
Solubility: Soluble in alcohol, propylene glycol; insoluble in water.
Other Names:
Pentanedioic acid, mono[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl] ester
FEMA 4006
Ultracool 2
L-Monomenthyl glutarate
FEMA Gras 4006
Monomenthyl glutamate
FEMA Number 4006
According to the Flavor and Extract Manufacturers Association (FEMA), the number of L-monomenthyl glutarate is FEMA 4006.
Bulk Monomenthyl Glutarate Manufacturers
The bulk production of monomenthyl glutarate is concentrated among specialized chemical manufacturers with expertise in ester synthesis and purification. Top monomenthyl glutarate manufacturers like International Flavors & Fragrances produce high-purity monomenthyl glutarate for food, cosmetic, and personal care applications. While established manufacturers dominate the market, new entrants are creating innovations in production methods and applications.
Sinofi is a bulk manufacturer of monomenthyl glutarate in China, and we have a manufacturing facility with 2,500 square meters for the production of monomenthyl glutarate cooling agent. We supply high-quality monomenthyl glutarate at bulk prices and serve food, flavour and fragrance, cosmetic and personal care industries worldwide.
Manufacturing Process of Monomenthyl Glutarate
The manufacturing of monomenthyl glutarate represents a blend of traditional chemical processes and modern industrial techniques. The carefully controlled esterification process, followed by meticulous purification steps, ensures a high-quality cooling agent that meets the stringent requirements of food, cosmetic, pharmaceutical, and personal care industries.
Raw Materials
The primary raw materials for monomenthyl glutarate production include:
- L-menthol – A cyclic monoterpene alcohol derived from mint oils or produced synthetically.
- Glutaric anhydride / Glutaric acid – A dicarboxylic acid that can be produced via oxidation of cyclopentane or through fermentation processes.
- Catalysts – Typically acid catalysts such as sulfuric acid or p-toluenesulfonic acid.
- Solvents – Usually toluene or xylene for azeotropic esterification.
Manufacturing Process
Esterification Reaction
The manufacturing process begins with the esterification of L-menthol with glutaric anhydride. This reaction occurs preferentially at one of the carboxylic acid groups of glutaric acid:
L-menthol + Glutaric anhydride → Monomenthyl glutarate + Water
The reaction is typically conducted at elevated temperatures (120-160°C) in the presence of an acid catalyst. Since esterification is an equilibrium reaction, the water formed must be continuously removed to drive the reaction toward completion.
Azeotropic Distillation
To enhance conversion rates, manufacturers employ azeotropic distillation using toluene or xylene as the azeotrope-forming solvent. This technique effectively removes water from the reaction mixture, pushing the equilibrium toward product formation.
As consumer demand for innovative cooling ingredients continues to grow, efficient and sustainable MMG production remains an important focus for manufacturers in this sector.
Bulk Monomenthyl Glutarate Suppliers
The global monomenthyl glutarate market is projected to grow steadily with increasing consumer preference for sensory-enhanced products. Top monomenthyl glutarate suppliers like International Flavors & Fragrances focus on sustainable production methods and enhanced purity profiles are likely to gain competitive advantages as regulatory requirements continue to evolve.
Sinofi is a bulk monomenthyl glutarate supplier in China, and we have a warehouse with 1,200 square meters for high-quality monomenthyl glutarate cooling agent. We sell different grades of monomenthyl glutarate at wholesale prices to food, flavor and fragrance, pharmaceutical, and cosmetic manufacturers.
Supply Chain of Monomenthyl Glutarate
Supply Chain Structure
The monomenthyl glutarate supply chain operates through a multi-tiered network:
Tier 1: Raw Material Suppliers
- Natural and synthetic menthol producers (primarily in India and China).
- Glutaric acid manufacturers (petrochemical companies).
- Catalyst and reagent suppliers.
Tier 2: Monomenthyl Glutarate Manufacturers
- Specialty chemical companies performing esterification processes of monomenthyl glutarate.
- Contract manufacturing organizations (CMOs).
- Large integrated chemical corporations with cosmetic ingredient divisions.
Tier 3: Distributors and Traders
- Chemical distribution companies.
- Trading houses specializing in cosmetic ingredients.
- Regional distributors with cold chain capabilities.
Tier 4: Formulators and Product Manufacturers
- Cosmetic companies.
- Personal care product manufacturers.
- Pharmaceutical companies.
- Contract development and manufacturing organizations (CDMOs).
Tier 5: Retailers and End Users
- Retail chains.
- Online marketplaces.
- Professional service providers (spas, clinics)
The supply chain of monomenthyl glutarate continues to adapt to changing market conditions. Growing demand for cooling sensations in personal care products is driving expansion, while sustainability concerns are reshaping production methods. Supply chain resilience has become a priority following recent global disruptions, with many companies implementing dual-sourcing strategies and building strategic inventory reserves.
Wholesale and Buy Monomenthyl Glutarate in Bulk
Purchasing monomenthyl glutarate in bulk offers significant advantages for manufacturers in food, flavor and fragrance, cosmetics, and pharmaceutical industries. Monomenthyl glutarate buyers need to establish relationships with reliable suppliers and to implement rigorous quality control measures. Hence, they can optimize their supply chain while ensuring consistent product quality.
Benefits of Wholesale Purchasing
Buying monomenthyl glutarate in bulk quantities delivers several key advantages:
- Cost efficiency: Significant unit price reductions compared to small-quantity purchases.
- Supply security: Establishing relationships with reliable suppliers ensures consistent availability.
- Quality consistency: Single-batch purchases minimize quality variations between production runs.
- Reduced administrative overhead: Fewer purchasing cycles mean less paperwork and processing time.
As a bulk manufacturer and supplier of monomenthyl glutarate in China, we supply high-quality monomenthyl glutarate for food, flavor and fragrance, pharmaceutical, and cosmetic industries. We also wholesale monomenthyl glutarate to small customers. Normally, they want to buy monomenthyl glutarate in small quantities. To serve them, we can wholesale monomenthyl glutarate at bulk prices and provide a one-stop purchasing service.
Monomenthyl Glutarate Prices (USD/Kg)
Food Grade L-Monomenthyl Glutarate Prices (purity >=72.0%)
| Volume | Unit Price | Shipment |
| 50g | 16 USD | Express |
| 500g | 75 USD | Express |
| 1Kg | 110 USD/Kg | Express |
| 20Kg | 20% cheaper | Express |
| 100Kg-Above | negotiable | Express / Sea |
The monomenthyl glutarate prices have experienced notable fluctuations in recent years, driven by shifting supply chain dynamics and evolving demand across multiple industries.
Several key factors have influenced monomenthyl glutarate pricing:
- Raw material availability – Glutaric acid and menthol, the primary components for monomenthyl glutarate synthesis, have faced their own supply constraints.
- Production concentration – Manufacturing remains centered in China and select European facilities.
- Transportation costs – While global shipping rates have normalized compared to previous years, they continue to impact final pricing.
For manufacturers and formulators utilizing monomenthyl glutarate, strategic sourcing agreements and inventory management remain essential tools for navigating price fluctuations in this specialty ingredient market.
Furthermore, the above price quotations of monomenthyl glutarate, especially for small orders, do not include the express shipping fee. The reason is that the shipment cost of monomenthyl glutarate may exceed the value of the sample. However, the bulk wholesale prices of monomenthyl glutarate will be much lower than those of small orders. Please contact us for more details.
Monomenthyl Glutarate Uses
Monomenthyl glutarate is an organic compound that has gained significant attention across various industries due to its unique properties and versatile applications.
Food and Beverage Uses
In the food sector, monomenthyl glutarate serves as a cooling agent that enhances consumer experience without overwhelming mint flavors. It’s used in:
- Chewing gums and candies for a subtle cooling sensation.
- Beverages that benefit from refreshing properties without a mint taste.
- Desserts where a cooling effect is desired without altering flavor profiles.
- Oral care products like mouthwashes and breath fresheners.
Cosmetics and Personal Care Uses
In the cosmetics and personal care industry, monomenthyl glutarate serves as an innovative cooling agent. Unlike traditional menthol, monomenthyl glutarate provides a refreshing sensation without the strong mint aroma, making it ideal for sensitive skin formulations. It’s commonly found in:
- Facial cleansers and toners that offer a cooling effect.
- After-sun products to soothe and calm irritated skin.
- Anti-aging creams where monomenthyl glutarate enhances the sensory experience.
- Body lotions that provide a refreshing feel upon application.
Pharmaceutical Uses
Pharmaceutical companies utilize monomenthyl glutarate for its cooling properties and as a permeation enhancer. Its applications include:
- Topical analgesic preparations for temporary pain relief.
- Anti-itch formulations where cooling sensations help reduce discomfort.
- Muscle relaxant products that benefit from their mild cooling effect.
- Transdermal delivery systems help improve drug absorption.
Monomenthyl Glutarate Benefits
Enhanced Cooling Benefits
Monomenthyl glutarate delivers a refreshing, cooling effect when applied to the skin. This cooling sensation is milder and longer-lasting than traditional menthol, making it ideal for products designed for extended wear or use on sensitive skin areas.
Lower Irritation Benefits
Monomenthyl glutarate can reduce the potential for skin irritation compared to menthol. This makes it suitable for use in products formulated for sensitive skin and in areas where irritation is a concern.
Versatility in Formulations
Monomenthyl glutarate is compatible with a wide range of cosmetic and pharmaceutical formulations. It can be incorporated into creams, lotions, gels, and even powder products, expanding formulators’ options for creating cooling products.
Pain Relief Benefits
The cooling effect of monomenthyl glutarate can provide temporary relief from minor aches, pains, and itching. This makes it valuable in topical analgesic products, soothing balms, and after-sun care formulations.
Enhanced Product Experience
In skincare and personal care products, monomenthyl glutarate contributes to a pleasant sensory experience. The gentle cooling sensation can make products feel more refreshing and invigorating, potentially improving consumer satisfaction.
As consumers continue to seek effective yet gentle skincare solutions, ingredients like monomenthyl glutarate are likely to gain more popularity. Its combination of cooling efficacy, formulation flexibility, and reduced irritation potential positions monomenthyl glutarate as an excellent choice for formulators looking to create innovative cooling products.
Monomenthyl Glutarate Used in Cosmetics
A Composite Essential Oil Blend for Refreshing the Mind
The main ingredients include (by weight): peppermint essential oil, 85 parts; geranium oil, 2 parts; menthyl glutarate, 5 parts; menthyl acetate, 3 parts; L-carvone, 3 parts; eucalyptus oil, 2 parts.
In conclusion, monomenthyl glutarate represents an advancement in cooling agent technology, offering formulators and consumers the benefits of cooling without many of the drawbacks associated with traditional cooling ingredients. As a bulk manufacturer and supplier of monomenthyl glutarate in China, we sell different grades of monomenthyl glutarate at wholesale prices to large manufacturers and small customers worldwide.