This section provides an overview of nicotinamide mononucleotide (NMN) powder, covering its manufacturing processes and regulatory status, and applications in the food, nutraceutical, and pharmaceutical industries. Also, please check out the introduction to nicotinamide mononucleotide manufacturers, supply chain issues, nicotinamide mononucleotide suppliers, and NMN powder prices. Sinofi can help you buy NMN powder at bulk wholesale prices, with CAS 1094-61-7.
Table of Contents
What is Nicotinamide Mononucleotide (NMN)?
Nicotinamide mononucleotide, abbreviated β-NMN, has moved in less than a decade from a laboratory reagent to one of the most requested actives in the healthy-aging category. As the immediate biosynthetic precursor of nicotinamide adenine dinucleotide (NAD⁺), NMN sits at the center of a metabolic pathway that underpins cellular energy production, DNA repair, sirtuin signaling, and mitochondrial maintenance. According to Nature, tissue NAD⁺ levels decline with human age, and the hypothesis is that supplemental NMN can restore them. It has generated an industry worth several billion dollars. Nicotinamide mononucleotide is a phosphorylated nucleotide, not a robust vitamin salt. It is hygroscopic, heat-labile, and unstable in water, and its regulatory status has shifted materially in the last twelve months in two of the world’s largest markets. According to the precision FDA, nicotinamide mononucleotide is regulated as a food supplement in the United States.
Regulatory Status and Safety Considerations
Nicotinamide mononucleotide has been evaluated by major regulatory bodies like EFSA, ECHACHEM, Cosing, and Food and Chemical Toxicology. The regulatory treatment of NMN varies considerably by market, and formulators must verify the current position in each target jurisdiction before commercialization.
United States
On 29 September 2025, following a citizen petition and litigation led by the Natural Products Association, the agency reversed that position, concluding that NMN had been marketed as a dietary supplement in the United States before the relevant drug authorization and was therefore not excluded. In December 2025, the agency confirmed the same conclusion in letters to ingredient suppliers that had previously filed New Dietary Ingredient Notifications. NMN remains a new dietary ingredient: a marketer must either file its own notification or source material from a supplier whose notification is on file, and self-affirmed GRAS is not an alternative to that requirement. Products must comply with current good manufacturing practice under 21 CFR Part 111, and claims are limited to structure/function statements accompanied by the standard disclaimer.
European Union
In May 2026, EFSA published a positive scientific opinion on chemically synthesized β-NMN for use in food supplements as a source of niacin at up to 300 mg/day for adults, excluding pregnant and lactating women. A positive opinion does not by itself permit marketing; an implementing regulation from the European Commission is required, and as of mid-2026, that step was still pending. According to the Food Standards Agency, the UK is also reviewing the use of NMN in food.
Japan
The Ministry of Health, Labor and Welfare confirmed in 2020 that NMN is a non-pharmaceutical (food) ingredient, and NMN has since been used freely in foods and supplements. Japan is the most mature NMN market and the origin of much of the early clinical work.
China
NMN has not been approved as a new food raw material for domestic sale on the mainland. Products reach Chinese consumers mainly through cross-border e-commerce channels.
Other markets
Canada regulates NMN as a natural health product ingredient requiring a product license; Australia, South Korea, and the ASEAN markets each apply their own listing or notification requirements.
Natural Occurrence and Biological Role
NMN is a normal constituent of living cells and is therefore present in trace quantities in many foods, including edamame, broccoli, cabbage, cucumber, avocado, raw beef, and shrimp. Reported concentrations are on the order of a milligram or less per 100 g of food. Ordinary dietary intake is therefore in the low-milligram range, which is two to three orders of magnitude below the 250–1,000 mg daily doses used in clinical studies. NMN, as a functional ingredient, is consequently sourced from manufactured material rather than concentrated from foods.
NMN occupies the final step of the mammalian NAD⁺ salvage pathway. Nicotinamide, released whenever NAD⁺ is consumed by sirtuins, poly(ADP-ribose) polymerases, or CD38, is recombined with phosphoribosyl pyrophosphate by nicotinamide phosphoribosyltransferase (NAMPT) to yield NMN. NMN is then adenylated by the nicotinamide mononucleotide adenylyltransferases (NMNAT1–3) to regenerate NAD⁺. NAMPT is the rate-limiting enzyme of this cycle, which is the mechanistic rationale for supplying NMN directly: it enters the pathway downstream of the bottleneck.
Tissue NAD⁺ concentrations decline with age in animals and, according to a growing body of human data, in people. Because NAD⁺ is both a redox cofactor and a substrate for enzymes that regulate mitochondrial function, DNA repair, and circadian signaling, this decline has been proposed to contribute to the age-related loss of metabolic resilience. Oral NMN raises circulating NAD⁺ metabolite levels in humans in a dose-dependent manner in the clinical studies published to date.
CAS No.: 1094-61-7
According to the American Chemical Society, the CAS number of nicotinamide mononucleotide is 1094-61-7.
Common Name: β-Nicotinamide mononucleotide (β-NMN)
Molecular Formula: C₁₁H₁₅N₂O₈P
Molecular Weight: 334.22 g/mol
Structural Components: Nicotinamide (pyridine-3-carboxamide) linked through a β-N-glycosidic bond to D-ribofuranose, which carries a phosphate group at the 5′ position.
Appearance: White to off-white crystalline powder
Solubility: Freely soluble in water; practically insoluble in ethanol and non-polar solvents
Relationship to other B3 vitamers: The 5′-phosphate ester of nicotinamide riboside (NR); the direct biosynthetic precursor of NAD⁺
Food Chemicals Codex Listed: No
Other Names:
♦ 3-Carbamoyl-1-β-D-ribofuranosylpyridinium hydroxide, 5′-phosphate, inner salt
♦ Nicotinamide mononucleotide
♦ Nicotinamide ribonucleotide
♦ NMN
♦ Nicotinamide ribotide
♦β-NMN
♦ Nicotinamide ribonucleoside 5′-phosphate
♦ NMN (mononucleotide)
♦β-D-NMN
♦ Fosribnicotinamide
Bulk Nicotinamide Mononucleotide Manufacturers
The bulk nicotinamide mononucleotide manufacturing has developed into a rapidly growing segment of the global longevity and nutritional supplement market. Top nicotinamide mononucleotide manufacturers like Abinopharm and EffePharm focus on pharmaceutical-grade NMN raw materials and provide bulk NMN powder for supplement manufacturers worldwide. Chinese manufacturers currently dominate large-scale production due to:
- Mature biotechnology infrastructure
- Large-scale production capacity
- Competitive manufacturing costs
Sinofi is a bulk manufacturer of nicotinamide mononucleotide (NMN) in China, and we have a 2,500-square-meter manufacturing facility for NMN production. We supply high-quality NMN powder at bulk prices and serve food, nutraceutical, and pharmaceutical industries worldwide.
Manufacturing Process of Nicotinamide Mononucleotide (NMN)
Biocatalytic and whole-cell routes are displacing purely chemical synthesis on the strength of absolute stereo control, mild aqueous conditions, cheaper feedstocks, and a markedly better environmental profile. The remaining differentiators among producers are enzyme engineering for stability and activity, the efficiency of cofactor regeneration, and, above all, the cost and robustness of downstream purification, which now accounts for the dominant share of manufacturing costs in most biological processes.
Route One: Chemical Synthesis
Phosphorylation of Nicotinamide Riboside
The most direct chemical route begins from nicotinamide riboside (NR) and installs the 5′-phosphate. The classical reagent system is the Yoshikawa phosphorylation, in which phosphoryl chloride is used in trimethyl phosphate as solvent at low temperature, typically between −5 °C and 5 °C. Trimethyl phosphate is not merely an inert medium; it coordinates the phosphorylating species in a manner that confers useful selectivity for the primary 5′-hydroxyl over the secondary hydroxyls. The intermediate dichlorophosphate is quenched with water or aqueous buffer to liberate the phosphate monoester. The economics of this route depend almost entirely on the cost of nicotinamide riboside, which is itself a non-trivial synthetic target.
Route Two: Cell-Free Enzymatic Synthesis
Biocatalysis addresses the two hardest problems of the chemical route simultaneously. Enzymes operate in water at ambient temperature and near-neutral pH, which protects the glycosidic bond, and they are absolutely stereospecific, which eliminates the α-anomer from the impurity profile entirely. Two enzymatic disconnections dominate.
Generate PRPP in situ from D-ribose through a three-enzyme cascade: ribokinase phosphorylates ribose to ribose-5-phosphate, PRPP synthetase converts ribose-5-phosphate to PRPP, and NAMPT performs the final transfer. Both of the first two steps consume ATP. A further refinement replaces ribose with starch or maltodextrin, using phosphorylase and isomerase enzymes to reach the pentose phosphate intermediates from a genuinely cheap feedstock.
The second disconnection uses nicotinamide riboside kinase (NRK, EC 2.7.1.22) to phosphorylate nicotinamide riboside at the 5′-position using ATP. This is the shorter and more atom-economical transformation, and it avoids PRPP altogether, but it inherits the cost of the nicotinamide riboside starting material.
Both routes are stoichiometric in ATP, which is prohibitive unless the cofactor is regenerated. The regeneration systems in industrial use are polyphosphate kinase with inexpensive inorganic polyphosphate as phosphoryl donor, acetate kinase with acetyl phosphate, and pyruvate kinase with phosphoenolpyruvate. Polyphosphate kinase is generally favoured on cost grounds. A second thermodynamic lever, specific to the NAMPT route, is the inclusion of inorganic pyrophosphatase, which hydrolyses the pyrophosphate co-product and pulls the equilibrium decisively toward NMN while relieving product inhibition.
The engineering challenges of cell-free cascades are enzyme stability over long reaction times, the cost of producing and purifying multiple recombinant enzymes, accumulation of inorganic phosphate, and the need to remove protein and nucleic acid from the product stream. Enzyme immobilization on solid supports, thermostability engineering by directed evolution, and the use of crude cell lysates rather than purified enzymes are the standard mitigations.
Route Three: Whole-Cell Biocatalysis and Fermentation
Whole-cell systems delegate cofactor supply to the organism’s own metabolism. An engineered host, commonly Escherichia coli, Bacillus subtilis, or Saccharomyces cerevisiae, is grown to high cell density and then fed nicotinamide together with a carbon source such as glucose, xylose, or ribose. Intracellular PRPP is drawn from the pentose phosphate pathway and ATP from central carbon metabolism, so neither expensive cofactor needs to be purchased.
The principal quality consideration specific to this route is host-derived contamination. Gram-negative hosts introduce bacterial endotoxin, and all microbial routes introduce host cell protein and residual DNA. Low-endotoxin E. coli strains, or the use of B. subtilis or S. cerevisiae, together with validated clearance in downstream processing, are the usual responses.
Bulk Nicotinamide Mononucleotide Suppliers
The bulk NMN market has matured from a commodity chase into a regulatory-positioning exercise. Top nicotinamide mononucleotide suppliers like Abinopharm and EffePharm supply the large majority of the world’s NMN raw material. This concentration is a structural feature of the market rather than a temporary condition. Industry estimates put the share of raw nutraceutical ingredients originating in China at as much as 80 percent across the category, and NMN sits at the higher end of that range.
Sinofi is a bulk NMN supplier in China, and we have a warehouse with 1,200 square meters for high-quality nicotinamide mononucleotide. We sell different grades of NMN powder at wholesale prices, serving end-users in the food, nutraceutical, and pharmaceutical industries.
Supply Chain of Nicotinamide Mononucleotide (NMN)
Nicotinamide mononucleotide has moved from a regulatory grey zone to a legitimately tradable dietary ingredient in the world’s largest supplement market in less than a year. The supply chain that serves this demand remains structurally lopsided. NMN manufacturing is concentrated in a small group of Chinese biocatalysis and fine-chemical producers, while the principal consumption markets are the United States, Japan, and, through indirect channels, China itself. The result is a chain in which regulatory approval status, rather than production capacity, is the binding constraint on who can sell where, and in which ingredient producers hold market-specific regulatory assets.
Supply Chain Structure
The NMN chain can be described in four tiers, from feedstock chemistry to the end consumer.
Feedstocks and Process Inputs
The starting materials for NMN are inexpensive, well-supplied commodity chemicals. Nicotinamide (vitamin B3 amide) is produced at very large scale from 3-cyanopyridine and is dominated by a handful of Chinese and European producers. D-ribose, adenosine triphosphate (ATP) or alternative phosphate donors, and recombinant enzymes are the other principal inputs for enzymatic routes. Producers using a one-step enzymatic route begin from nicotinamide riboside (NR), which itself is a manufactured intermediate rather than a commodity.
NMN Manufacturing
The enzymatic route has become the dominant commercial method and the basis of most branded NMN ingredients. Production is concentrated in eastern and southern China. Quality control at this tier revolves around purity, the beta-anomer ratio (only β-NMN is biologically relevant), residual solvents, heavy metals, microbial limits, and, increasingly, stability and hygroscopicity data.
Formulation and Contract Manufacturing
Finished-product manufacturing is geographically dispersed and closely follows the destination market. United States brands rely on domestic contract manufacturers operating under current Good Manufacturing Practice for dietary supplements; Japanese brands use domestic or Chinese fill-and-finish capacity; European brands have largely held back pending Commission authorization.
Wholesale and Buy Nicotinamide Mononucleotide in Bulk
For NMN buyers, price should be only one part of the purchasing decision. They should review NMN purity, batch consistency, COA documentation, manufacturing quality, third-party testing, packaging, delivery capability, and supplier reliability. Before making a commercial purchase, buyers should also confirm the regulatory status and permitted uses of NMN in their destination market, as requirements may vary by country and application.
Understanding the Product
The commercially relevant form is the beta anomer, β-NMN; the alpha anomer has no established biological value and should be treated as an impurity. Commercial NMN is supplied as a white crystalline powder, typically at a labeled assay of 99 percent or higher by HPLC.
Supplier Qualification
A structured qualification process protects the organization far more reliably than a favorable quotation. The following elements should be standard. Establish whether the counterparty operates its own production facility or resells material from others. Traders can offer flexibility on volume, but the buyer must still trace material to the actual manufacturing site for audit and regulatory purposes.
Certifications and Audits
Request current certificates for the manufacturing site, such as GMP, ISO 22000, FSSC 22000, HACCP, or NSF, and, where possible, confirm their validity directly with the issuing body. For strategic volumes, an on-site audit or an accredited third-party audit is appropriate.
Documentation Package
At minimum, obtain a certificate of analysis for each lot, a product specification sheet, a safety data sheet, a manufacturing flow chart, allergen and GMO statements, a residual solvent statement, and, for the U.S. market, evidence of NDI notification status. Kosher and halal certificates may be required depending on the customer base.
As a bulk nicotinamide mononucleotide manufacturer and supplier in China, we wholesale this ingredient to end users in the food, nutraceutical, and pharmaceutical industries. We also supply high-quality NMN powder for sale. Normally, small customers want to buy nicotinamide mononucleotide in small quantities. To serve them, we can sell NMN powder at bulk prices and provide a one-stop purchasing service.
Nicotinamide Mononucleotide Prices (USD/Kg)
Food Grade NMN Powder Prices (HPLC Content >=99.5%)
| Volume | Unit Price | Shipment |
| 50g | 16 USD | Express |
| 500g | 80 USD | Express |
| 1Kg | 120 USD/Kg | Express |
| 25Kg | 96 USD/Kg | Express |
| 100Kg | >=30% cheaper | Express / Sea |
| 200Kg-Above | negotiable | Express / Sea |
The enzymatic nicotinamide mononucleotide prices of 99% purity from Chinese manufacturers are estimated to be at roughly US$70-130/kg in wholesale quantities in 2025–2026. Some premium, branded, or fully documented food-grade NMN powder commands US$160–370/kg, and pharmaceutical-grade raw material is cited as high as US$500-2000/kg. This represents a sharp decline from the US$3,000/kg level of 2018-2019. Meanwhile, retail NMN powder prices in North America and Europe remain high. In 2026, retail NMN supplements run roughly US$40-120 per month for 500–1,000 mg daily dosing. On a per-gram basis, the spread among brands is dramatic: Jinfiniti’s NMN powder is US$1.93/g, while competitor products range from US$2.67/g (PartiQlar) to US$8.00/g (Lifeforce Peak NMN), with liposomal and multi-ingredient formats commanding the top of the range.
Furthermore, the above NMN price quotations do not include the express fee. The reason is that the shipment cost may exceed the sample value of nicotinamide mononucleotide. However, the wholesale prices for NMN powder will be much lower than for small orders. Please contact us for more details.
Nicotinamide Mononucleotide Specification
| Appearance | White powder or granular |
| Purity (HPLC) | >=99.5% |
| Content | 98.0% – 102.0% |
| Loss on Drying (%) | <=0.5 |
| Residue on Ignition (%) | <=0.1 |
| pH (5% solution) | 3.0-4.0 |
| Heavy Metals (as Pb, ppm) | <=10 |
| Ethanol | <=0.5g/Kg |
| Sodium (as Na) | <=0.05% |
Nicotinamide Mononucleotide Uses
NMN is a nucleotide composed of a nicotinamide group, a ribose sugar, and a phosphate group. In human cells, it is synthesized from nicotinamide by the enzyme nicotinamide phosphoribosyltransferase (NAMPT), and it is subsequently converted to NAD+ by a family of enzymes known as nicotinamide mononucleotide adenylyltransferases (NMNATs).
Uses Examined in Human Research
Human trials of NMN remain relatively small and short in duration, generally lasting between four and twelve weeks and enrolling a few dozen participants each. Nevertheless, several areas of potential use have been studied in randomized, placebo-controlled designs.
Uses Supported Primarily by Preclinical Research
Animal and cell-based studies have explored a much wider range of applications than human trials. In rodent models, NMN has been reported to improve mitochondrial function in aging muscle, protect cardiac tissue after ischemia, restore blood-vessel density and blood flow, reduce markers of neuroinflammation, and preserve cognitive performance in models of Alzheimer’s disease. A 2025 systematic review found consistent improvements in oocyte quality across preclinical models of reproductive aging, with transcriptomic data pointing to mitochondrial and oxidative stress pathways as plausible mechanisms.
These results explain much of the enthusiasm surrounding NMN, but the history of nutritional science offers many examples of compounds that performed well in mice and disappointed in people. Differences in dosing, metabolism, and lifespan mean that preclinical findings cannot be assumed to apply to humans until confirmed in adequately powered trials.
Markers of Biological Aging
A small number of studies have assessed composite measures of “biological age” derived from routine blood tests. In the 60-day dose-ranging trial noted above, biological age remained stable in the NMN groups while it increased in the placebo group over the same period. These algorithms are still under scientific development, and the clinical meaning of such changes has not been established.
Nicotinamide Mononucleotide Benefits
NAD+ participates in two broad categories of cellular activity. First, it serves as an electron carrier in the reactions that convert nutrients into usable energy within the mitochondria. Second, it acts as a substrate for several families of regulatory enzymes, including sirtuins, which influence gene expression, stress resistance, and metabolic regulation, and PARPs, which are involved in DNA repair. Research in animals and humans indicates that NAD+ availability in tissues declines with advancing age. This decline has been associated with reduced mitochondrial efficiency, impaired DNA repair, chronic low-grade inflammation, and metabolic dysfunction. The central hypothesis behind NMN supplementation is that restoring NAD+ to more youthful levels may slow or partially reverse some of these age-related changes.
Restoration of NAD+ Levels
The most consistently demonstrated effect of oral NMN in humans is an increase in blood NAD+ and related metabolites. Randomized, placebo-controlled trials conducted in Japan, China, India, and the United States have reported significant increases at daily doses ranging from 250 mg to over 1,000 mg, with larger doses generally producing larger increases. A 2025 meta-analysis pooling several hundred trial participants confirmed that this elevation is robust across study populations. Whether a higher blood NAD+ concentration translates into meaningful changes in tissues and organs remains a separate question, and one that current research is only beginning to address.
Vascular and Cardiovascular Health
Animal research has shown that NMN can improve arterial elasticity and blood flow. Human evidence remains preliminary. A 12-week trial in healthy middle-aged adults observed a trend toward reduced arterial stiffness, as measured by pulse wave velocity, but the difference did not reach statistical significance. Short-term studies in overweight adults using higher doses have reported small reductions in body weight, diastolic blood pressure, and LDL cholesterol, though these require confirmation in longer trials.
An Anti-aging and Antioxidant Tablet Using NMN Powder
Include the following ingredients (by weight):
Modified urolithin A sustained-release microspheres: 5 parts;
Rubin-phosphatidylserine nanocomposite: 3 parts;
Spermine-ergothioneine molecular cocrystal: 2 parts;
Nicotinamide mononucleotide: 50 parts;
Resveratrol: 20 parts;
Astaxanthin: 5 parts;
Pyrroloquinoline quinone disodium salt (PQQ): 5 parts;
Vitamin C: 30 parts;
Vitamin E: 10 parts;
Excipients as needed.
In conclusion, nicotinamide mononucleotide has emerged as one of the most prominent ingredients in the global healthy aging and longevity market. As a bulk nicotinamide mononucleotide manufacturer and supplier in China, we sell different grades of NMN powder at wholesale prices to clients around the world.