This section focuses on an overview of cis-3-hexenyl isovalerate as well as its manufacturing processes and uses. Also, please check out the introduction to cis-3-hexenyl isovalerate manufacturers, supply chain issues, cis-3-hexenyl isovalerate suppliers, and cis-3-hexenyl isovalerate prices. Sinofi can help you buy high-quality cis-3-hexenyl isovalerate in bulk for your industry applications at wholesale prices based on FEMA 3498 and CAS 35154-45-1 or 10032-11-8.
Table of Contents
What is Cis-3-Hexenyl Isovalerate?
Cis-3-hexenyl isovalerate is an organic ester compound that plays a significant role in the fragrance and flavor industry. This naturally occurring chemical compound is renowned for its distinctive green, fruity aroma that closely resembles fresh apples and green leaves. The compound belongs to the broader family of hexenyl esters, which are important constituents in many natural fragrances and food flavoring systems. Cis-3-hexenyl isovalerate consists of two primary components: a cis-3-hexenyl alcohol moiety and an isovaleric acid (3-methylbutanoic acid) portion, connected through an ester linkage. According to the U.S. Food and Drug Administration (FDA), cis-3-hexenyl isovalerate is approved to be used in the food, beverage, flavour, and fragrance industries. It has also been evaluated by relevant regulatory authorities like JECFA, EUR-Lex, ECHACHEM, NIST, and WHO. The fragrance industry follows standards set by organizations such as the International Fragrance Association (IFRA) and the Research Institute for Fragrance Materials (RIFM).
Natural Occurrence and Sources
Cis-3-hexenyl isovalerate occurs naturally in various plant materials, particularly in fruits and green plant tissues. The compound is commonly found in apple varieties, where it contributes to the characteristic fresh, green apple scent. It is also present in certain citrus fruits, berries, and leafy vegetables, often in conjunction with other volatile organic compounds that collectively create complex natural aromas. The compound can be extracted from natural sources through steam distillation or solvent extraction methods, though commercial production typically relies on synthetic manufacturing processes due to cost considerations and supply consistency requirements.
Primary Aromatic Characteristics
- Fresh green apple fragrance with prominent fruit notes.
- Subtle hints reminiscent of fresh blueberries.
- Delicate pineapple undertones that add tropical complexity.
- Secondary notes that include valerian-type characteristics and ripe fruity accents.
CAS No.: 35154-45-1 or 10032-11-8
According to the American Chemical Society, the CAS numbers of cis-3-hexenyl isovalerate are 35154-45-1 or 10032-11-8.
CAS Name: cis-3-Hexenyl isovalerate, 3-Hexenyl isovalerate
Molecular Formula: C11H20O2
Molecular Mass: 184.28
Appearance: Colorless, clear liquid
Boiling Point: 199.00 °C. @ 760.00 mm Hg
Solubility: Soluble in alcohol, fixed oils, and propylene glycol. Insoluble in water (19.61 mg/L @ 25 °C)
Other Names:
♦ cis-3-Hexenyl isovalerate
♦ cis-3-Hexenyl isopentanoate
♦ cis-3-Hexenyl 3-methylbutyrate
♦ (Z)-3-Hexenyl isovalerate
♦ (Z)-3-Hexen-1-yl isovalerate
♦ (Z)-3-Hexenyl 3-methylbutyrate
♦ (3Z)-Hexenyl isovalerate
Cis-3-Hexenyl Isovalerate Odor
Odor Strength: Medium
Substantivity: 4 hours at 100.00 %
At 10.00 % in dipropylene glycol. fresh green apple, fruity tropical pineapple.
FEMA Number 3498
According to the Flavor and Extract Manufacturers Association (FEMA), the number of cis-3-hexenyl isovalerate is FEMA 3498.
Bulk Cis-3-Hexenyl Isovalerate Manufacturers
The bulk cis-3-hexenyl isovalerate manufacturing is dominated by several major corporations that maintain significant production capabilities for aroma chemicals. Top cis-3-hexenyl isovalerate manufacturers like Givaudan and Mane offer distinct advantages for different customer requirements. Givaudan stands as the world’s largest fragrance and flavor company. With extensive global operations and strong research capabilities, Givaudan maintains substantial manufacturing capacity for specialty aroma chemicals. The industry’s concentrated structure provides stability and technical expertise, while emerging manufacturers offer competitive alternatives and regional advantages.
Sinofi is a bulk manufacturer of cis-3-hexenyl isovalerate in China, and we have a manufacturing facility with 2,500 square meters for the production of cis-3-hexenyl 3-methylbutyrate. We supply high-quality cis-3-hexenyl isovalerate at bulk prices and serve the food, beverage, flavour, and fragrance industries worldwide.
Manufacturing Process of Cis-3-Hexenyl Isovalerate
The production of cis-3-hexenyl isovalerate follows a standard esterification reaction pathway, employing either direct acid-catalyzed esterification or alternative synthetic routes depending on manufacturing scale and efficiency requirements.
Raw Material Requirements
The manufacturing process requires two primary chemical precursors: cis-3-hexen-1-ol and isovaleric acid. cis-3-Hexen-1-ol, also known as leaf alcohol, provides the characteristic green note and can be sourced through synthetic routes or natural extraction methods. Isovaleric acid, a branched-chain carboxylic acid, serves as the acylating agent in the esterification reaction. Additional materials include appropriate catalysts, typically acid catalysts such as sulfuric acid or p-toluenesulfonic acid, and suitable solvents when required for reaction optimization. The quality and purity of starting materials directly influence the final product characteristics and yield efficiency.
Manufacturing Process
In the direct esterification method, cis-3-hexen-1-ol and isovaleric acid undergo reaction in the presence of an acid catalyst under controlled temperature conditions, typically ranging from 60 to 120 degrees Celsius. The reaction proceeds according to the following mechanism: the acid catalyst protonates the carboxylic acid, enhancing its electrophilic character and facilitating nucleophilic attack by the alcohol. Water formation occurs as a byproduct, requiring continuous removal to drive the equilibrium toward ester formation.
The reaction mixture undergoes continuous stirring and temperature monitoring to ensure optimal conversion rates while preventing decomposition of temperature-sensitive components. Reaction progress can be monitored through gas chromatography analysis or acid value determination to assess completion.
Following reaction completion, the crude product requires purification through distillation processes. Initial water removal occurs through azeotropic distillation or simple phase separation, followed by fractional distillation to achieve the desired purity specifications. The distillation parameters must be carefully controlled to prevent thermal degradation of the sensitive ester bonds.
Success in this manufacturing operation requires careful attention to raw material quality, process optimization, and comprehensive quality control systems.
Bulk Cis-3-Hexenyl Isovalerate Suppliers
The bulk cis-3-hexenyl isovalerate supply market reflects broader industry trends toward natural ingredients and enhanced quality standards. Top cis-3-hexenyl isovalerate suppliers like Givaudan and Mane provide comprehensive coverage for diverse industrial requirements. Givaudan has developed expertise in research, production, and quality assurance of flavor and fragrance ingredients, offering comprehensive inventory access for flavoring, cosmetic, and personal care applications.
Sinofi is a bulk cis-3-hexenyl isovalerate supplier in China, and we have a warehouse with 1,200 square meters for high-quality cis-3-hexenyl 3-methylbutyrate. We sell different grades of cis-3-hexenyl isovalerate at wholesale prices to food, beverage, flavour, and fragrance manufacturers.
Supply Chain of Cis-3-Hexenyl Isovalerate
The cis-3-hexenyl isovalerate supply chain features a diverse ecosystem of suppliers ranging from multinational chemical companies to specialized aroma chemical manufacturers. This competitive landscape reflects the varying customer needs across different market segments and geographic regions. It demonstrates the sophisticated structure and complex dynamics characteristic of specialty chemical markets.
Supply Chain Structure Overview
This structure demonstrates the characteristic complexity of aroma chemical distribution, with multiple intermediary steps adding value through specialized processing, quality assurance, and market access capabilities.
Raw Material Suppliers
The foundation of the supply chain rests on providers of basic chemical building blocks required for synthesizing cis-3-hexenyl isovalerate. These suppliers typically operate large-scale chemical manufacturing facilities and provide commodity chemicals, including cis-3-hexen-1-ol, isovaleric acid, and esterification catalysts. The reliability and cost structure of these upstream suppliers significantly influence the overall economics of cis-3-hexenyl isovalerate production.
Primary Manufacturers
Primary manufacturers represent the core production tier, transforming basic chemical feedstocks into finished cis-3-hexenyl isovalerate through specialized esterification processes. These companies invest heavily in process optimization, quality control systems, and regulatory compliance infrastructure.
Specialty Chemical Distributors
The distribution tier serves as a critical intermediary, providing market access, inventory management, and customer service capabilities that connect primary manufacturers with end-users. These distributors maintain extensive product portfolios, technical support capabilities, and regional market expertise. Many distributors specialize in specific market segments, such as fine fragrance, personal care, or food flavoring applications.
Fragrance Houses and Flavor Companies
Fragrance houses and flavor companies represent sophisticated buyers who incorporate cis-3-hexenyl isovalerate into complex formulations. These companies possess extensive technical expertise in fragrance creation, consumer preference research, and application development. They typically maintain long-term relationships with cis-3-hexenyl isovalerate suppliers and require consistent quality, reliable supply, and comprehensive technical support.
End Users
The final tier encompasses companies that incorporate fragranced products into consumer goods, including cosmetics, personal care products, household cleaners, and food products. These manufacturers typically work through fragrance houses rather than sourcing aroma chemicals directly, but their requirements and preferences ultimately drive demand patterns throughout the supply chain.
Success in this market requires careful attention to quality assurance, regulatory compliance, customer relationship management, and supply chain resilience while adapting to evolving market trends and sustainability requirements.
Wholesale and Buy Cis-3-Hexenyl Isovalerate in Bulk
Wholesale procurement of cis-3-hexenyl isovalerate requires careful consideration of quality, regulatory compliance, storage requirements, and supplier capabilities. The compound’s stability and broad application range make it suitable for bulk purchasing strategies, provided that proper infrastructure and quality systems support the procurement decision. Success in bulk procurement ultimately depends on balancing cost optimization with quality assurance and supply chain reliability to support consistent manufacturing operations.
Wholesale Purchasing Considerations
When procuring cis-3-hexenyl isovalerate in bulk quantities, several factors warrant careful consideration. Volume requirements typically begin at the 25-kilogram level for industrial applications, with many suppliers offering more favorable pricing structures for orders exceeding 100 kilograms. The compound’s stability allows for larger inventory commitments without significant degradation concerns.
Price volatility in the raw materials market, particularly for isovaleric acid derivatives, can impact overall costs. Forward contracting with suppliers often provides price stability for annual requirements, though this approach requires accurate demand forecasting and adequate storage capabilities.
Quality specifications become paramount in bulk purchasing decisions. The compound should meet food-grade standards when intended for flavoring applications, requiring compliance with relevant FDA, EU, and other regional regulatory frameworks. For fragrance applications, cosmetic-grade specifications ensure compatibility with finished product requirements.
As a bulk manufacturer and supplier of cis-3-hexenyl isovalerate in China, we supply high-quality ingredients for the food, beverage, flavour, and fragrance industries. We also wholesale cis-3-hexenyl isovalerate to small customers. Normally, they want to buy cis-3-hexenyl isovalerate in small quantities. To serve them, we can wholesale cis-3-hexenyl isovalerate at bulk prices and provide a one-stop purchasing service.
Cis-3-Hexenyl Isovalerate Prices (USD/Kg)
Food Grade Cis-3-Hexenyl Isovalerate Prices (FCC, GC Content >=98.0%)
| Volume | Unit Price | Shipment |
| 50g | 45 USD | Express |
| 500g | 224 USD | Express |
| 1Kg | 320 USD/Kg | Express |
| 20Kg | 20% cheaper | Express |
| 100Kg-Above | negotiable | Express / Sea |
Cis-3-hexenyl isovalerate pricing reflects the dynamics of a specialized chemicals market characterized by technical applications, regulatory compliance requirements, and growing sustainability focus. While specific pricing data remains proprietary to suppliers and customers, the broader market trends indicate sustained demand growth and premiumization pressures that support stable to increasing price levels for this important ingredient.
Market Drivers Affecting Price Trends
Several key drivers are shaping the pricing environment for cis-3-hexenyl isovalerate. Growing demand for natural and sustainable products: Consumers have been increasingly seeking natural and sustainable ingredients in personal care and fragrance products. This trend supports premium pricing for compounds that can meet clean-label requirements. Rising interest in personal care and grooming products: The global personal care industry has been witnessing growth due to increased awareness about personal grooming and hygiene. This expanding market base creates sustained demand that supports stable or increasing pricing trends.
Furthermore, the above price quotations of cis-3-hexenyl isovalerate do not include the express shipping fee. The reason is that the shipment cost of cis-3-hexenyl 3-methylbutyrate may exceed the value of the sample. However, the bulk wholesale prices of cis-3-hexenyl isovalerate will be much lower than those of small orders. Please contact us for more details.
Cis-3-Hexenyl Isovalerate Uses
Fragrance Uses
The fragrance industry represents the largest consumer segment for cis-3-hexenyl isovalerate. Perfumers value this compound for its ability to provide fresh, green top notes that enhance floral compositions and add natural complexity to synthetic formulations. The compound serves as a bridge between fruity and green olfactory families, making it versatile for various fragrance types. In fragrance applications, cis-3-hexenyl isovalerate contributes essential green and fruity notes that enhance the complexity and appeal of various fragrance compositions. The compound is particularly valuable in creating fresh, natural fragrances that evoke outdoor environments and natural fruit scents.
Food and Beverage Uses
In the food and beverage sector, cis-3-hexenyl isovalerate serves as an approved flavoring agent. The compound has received FEMA approval (FEMA 3498), confirming its safety for use in food applications. Its green apple and berry-like flavor profile makes it particularly suitable for fruit-flavored beverages, confectionery products, and food items where a fresh, natural fruit taste is desired. The compound’s ability to provide authentic green apple notes with subtle berry undertones allows food technologists to create complex flavor profiles that enhance consumer appeal while maintaining the perception of naturalness that modern consumers increasingly demand.
Cosmetic and Personal Care Uses
The cosmetic and personal care industry utilizes this compound in products ranging from perfumes and colognes to scented personal care items such as shampoos, body washes, and lotions. Its ability to provide lasting freshness while maintaining a natural character makes it an important tool for formulators developing products that meet consumer expectations for both performance and sensory experience.
Regulatory Status and Safety
The compound’s regulatory approval for use in food applications through FEMA recognition demonstrates its established safety profile when used at appropriate concentrations. This regulatory foundation provides manufacturers with confidence in incorporating the compound into consumer products while maintaining compliance with applicable safety standards.
Safety documentation indicates the compound requires specific handling protocols, including protection from heat sources and ignition points, along with environmental protection measures due to aquatic toxicity considerations. These regulatory requirements necessitate appropriate supplier expertise in handling, storage, and transportation procedures.
Cis-3-Hexenyl Isovalerate Benefits
Sensory Profile and Aromatic Benefits
One of the most notable characteristics of cis-3-hexenyl isovalerate is its complex and appealing fragrance profile. The compound produces a fresh, fruity aroma that combines several distinct notes. This multifaceted aromatic profile makes the compound particularly valuable for perfumers and fragrance creators, who have noted that it provides an interesting and unique dimension to fragrance compositions. The green, fresh quality of the scent evokes natural outdoor environments and contributes to products that aim to capture the essence of fresh fruits and natural settings.
Key Benefits
- Provides long-lasting fragrance stability in formulations.
- Contributes to complex, sophisticated scent profiles.
- Offers consumers an appealing sensory experience.
- Enhances product differentiation in competitive markets.
Environmental and Sustainability Benefits
Modern production methods for cis-3-hexenyl isovalerate increasingly focus on sustainability and environmental responsibility. While the compound occurs naturally in many plants, commercial production often involves laboratory synthesis to ensure consistency and protect natural resources.
Sustainability Advantages
- Synthetic production reduces pressure on natural plant sources.
- Renewable materials are increasingly used in manufacturing processes.
- Consistent quality and purity through controlled production methods.
- Reduced environmental impact compared to large-scale natural extraction.
Cis-3-Hexenyl Isovalerate Used in Flavour and Fragrance
A Production Method of A Composite Mint Flavour
Include the following ingredients (by weight, %):
- Component A: Asian mint oil, 7.5%; menthone, 1.6%; menthyl acetate, 5.5%; limonene, 2%; octanol-3, 2.2%; L-carvone, 1.1%; β-caryophyllene, 1%; nonanal, 0.5%; dihydrocarvone, 0.5%; cis-3-hexenyl isovalerate, 2.75%; isoborneol acetate, 1.65%; phenylethyl alcohol, 1%; ethyl lactate, 1.65%; ethyl acetate, 3.85%; propylene glycol, 60%.
- Component B: Neomenthol, 3.9%; L-menthol, 3.3%.
- Heat component B at a constant temperature of 60°C until the crystals are completely melted.
- Stir all the raw materials except propylene glycol thoroughly and mix them evenly; Cool naturally. Evaluate sensory.
- Add propylene glycol, stir and mix it, mature for 20 to 30 minutes, and then test the fragrance.
- The final mix in the previous step is sterilized by ultraviolet light, then it is weighed and filled with nitrogen.
In conclusion, cis-3-hexenyl isovalerate represents a successful example of how natural compounds can be understood, synthesized, and applied to meet modern industrial needs. As a bulk cis-3-hexenyl isovalerate manufacturer and supplier in China, we sell different grades of cis-3-hexenyl isovalerate at wholesale prices to large manufacturers and small customers worldwide.