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Home - Pyridines - 2-Acetylpyridine

2-Acetylpyridine

2-Acetylpyridine

This section provides an overview of 2-acetylpyridine, covering its manufacturing processes, food and vape flavour applications, and regulatory status. Also, please check out the introduction to 2-acetylpyridine manufacturers, supply chain issues, 2-acetylpyridine suppliers, and 2-acetylpyridine prices. Sinofi can help you buy 2-acetylpyridine in bulk for your industry applications at wholesale prices based on FEMA 3251 and CAS 1122-62-9.

Table of Contents

  • What is 2-Acetylpyridine?
  • CAS No. 1122-62-9
  • 2-Acetylpyridine Odor
  • FEMA Number 3251
  • Bulk 2-Acetylpyridine Manufacturers
  • Manufacturing Process of 2-Acetylpyridine
  • Bulk 2-Acetylpyridine Suppliers
  • Supply Chain of 2-Acetylpyridine
  • Wholesale and Buy 2-Acetylpyridine in Bulk
  • 2-Acetylpyridine Prices (USD/Kg)
  • 2-Acetylpyridine Specification
  • 2-Acetylpyridine Uses
  • 2-Acetylpyridine in E-liquid and Vaping Products
  • 2-Acetylpyridine Benefits
  • 2-Acetylpyridine Used in Flavour and Fragrance
  • A Tobacco Flavouring Using 2-Acetylpyridine

What is 2-Acetylpyridine?

2-Acetylpyridine represents a significant heterocyclic aromatic compound in the flavour and fragrance industry. This nitrogen-containing ketone serves as both a flavouring agent and a valuable intermediate in the synthesis of other flavour compounds. 2-Acetylpyridine features a pyridine ring with an acetyl group attached at the 2-position, creating a structure that combines the aromatic properties of pyridine with the reactivity of a ketone functional group. This unique structural arrangement contributes to its distinctive organoleptic properties and chemical behavior. The presence of both nitrogen in the heterocyclic ring and the carbonyl group makes this molecule particularly interesting from a flavour chemistry perspective, as these functional groups significantly influence its sensory characteristics and reactivity. According to the U.S. Food and Drug Administration (FDA), 2-acetylpyridine is approved to be used in the e-liquid, food, flavour, and fragrance industries.

Regulatory Status and Safety Considerations

2-Acetylpyridine has been evaluated by major regulatory bodies like JECFA, EFSA, RIFM, ECHACHEM, Eur-Lex, NIST, and WHO. It holds GRAS (Generally Recognized As Safe) status in the United States when used in accordance with good manufacturing practices. In the United States, the compound holds GRAS status (FEMA 3251) when used in accordance with good manufacturing practices, typically at levels not exceeding 10 ppm in finished foods. European regulations include 2-acetylpyridine on the Union List of approved flavouring substances, with specific usage levels defined for different food categories. The fragrance standard of 2-acetyl pyridine has been set by organizations such as IFRA.
Formulators must ensure compliance with regional regulations and maximum permitted levels, which may vary by food category and jurisdiction. Documentation of usage levels and adherence to specifications remains critical for regulatory compliance.

2-acetylpyridine-1122-62-9

Sensory Characteristics and Flavour Profile

The organoleptic properties of 2-acetylpyridine make it particularly valuable in specific flavour applications. The compound presents a characteristic popcorn-like, nutty, and roasted aroma with subtle bread crust notes. At appropriate dilutions, it contributes warm, toasted, and slightly sweet nuances that enhance the complexity of various flavour systems. The flavour threshold for 2-acetylpyridine typically ranges from 0.02 to 0.06 ppm in aqueous solutions, demonstrating its potency as a flavouring agent. This low threshold necessitates careful dosage control during formulation to achieve the desired sensory impact without overwhelming other flavour components. The compound’s flavour profile evolves with concentration, transitioning from pleasant nutty notes at low levels to more pungent, medicinal characteristics at higher concentrations.

CAS No.: 1122-62-9

According to the American Chemical Society, the CAS number of 2-acetyl pyridine is 1122-62-9.
CAS Name: 2-Acetylpyridine
Molecular Formula: C7H7NO
Molecular Mass: 121.14
Appearance: White to light yellow, clear liquid
JECFA Number: 1309
Boiling Point: 189.00 to 193.00 °C. @ 760.00 mm Hg
Solubility: Soluble in ether and acids.
Other Names:
♦ Methyl 2-Pyridyl Ketone
♦ Ethanone, 1-(2-Pyridinyl)-
♦ Ketone, Methyl 2-Pyridyl
♦ 2-Acetylpyridine
♦ 2-Acetopyridine
♦ 1-(2-Pyridinyl)Ethanone

2-Acetylpyridine Odor

Odor Strength: High; recommend smelling in a 1.00 % solution or less
Substantivity: 9 hour(s) at 100.00 %.
popcorn corn chip fatty tobacco
Odor Description: At 1.00 % in propylene glycol, tobacco-like, popcorn, heavy-oily-fatty aroma.

FEMA Number 3251

According to the Flavour and Extract Manufacturers Association (FEMA), the FEMA number of 2-acetylpyridine is 3251.

Bulk 2-Acetylpyridine Manufacturers

The bulk 2-acetylpyridine manufacturing sector operates within a relatively concentrated market structure, with global production capacity estimated at several thousand metric tons annually. Top 2-acetylpyridine manufacturers like Givaudan and Ernesto Ventos maintain their positions as major players through extensive research and development capabilities. Chinese 2-acetylpyridine manufacturers have established dominant positions through vertical integration strategies and cost-competitive production models. They benefit from proximity to raw material sources and have invested substantially in production technology optimization over the past decade. Leading Chinese manufacturers typically operate multipurpose plants capable of producing various pyridine derivatives, allowing for operational flexibility and risk diversification. The market demonstrates steady growth patterns driven primarily by expanding applications in pharmaceutical synthesis and increasing demand from the food and beverage industry for authentic flavour compounds.
Sinofi is a bulk 2-acetylpyridine manufacturer in China, and we have a manufacturing facility with 2,500 square meters for the production of 2-acetylpyridine. We supply high-quality 2-acetylpyridine at bulk prices and serve global clients in e-liquid, pharmaceutical, food, flavour, and fragrance industries.

Manufacturing Process of 2-Acetylpyridine

The industrial synthesis of 2-acetylpyridine represents a significant challenge in heterocyclic chemistry, requiring careful consideration of reaction pathways, process efficiency, and product quality. As a versatile intermediate and flavouring agent with applications spanning pharmaceutical synthesis to food technology, the commercial production of this compound demands robust and economically viable manufacturing processes.

Principal Synthetic Routes

The manufacturing of 2-acetylpyridine primarily proceeds through three established synthetic pathways, each presenting distinct advantages and challenges from both chemical and economic perspectives. The most widely adopted industrial route involves the acetylation of pyridine derivatives, leveraging the nucleophilic character of the pyridine nitrogen to direct regioselective substitution. This approach typically employs acetyl chloride or acetic anhydride as acetylating agents under controlled conditions to achieve the desired 2-substitution pattern.
The second major pathway utilizes the oxidation of 2-ethylpyridine, converting the ethyl substituent to the corresponding acetyl group through controlled oxidation. This transformation requires careful selection of oxidizing agents and reaction conditions to prevent overoxidation while maintaining acceptable yields. Industrial implementations often employ catalytic systems that enable selective oxidation while minimizing byproduct formation.
A third approach involves the condensation of 2-pyridinecarboxaldehyde with methylmagnesium halides, followed by oxidation of the resulting secondary alcohol. While this route offers excellent regioselectivity, the requirement for organometallic reagents and multiple reaction steps generally limits its application to specialized production scenarios where high purity requirements justify the increased complexity and cost.

Bulk 2-Acetylpyridine Suppliers

The bulk 2-acetylpyridine supply exhibits clear segmentation based on operational models, service capabilities, and target customer bases. Top 2-acetylpyridine suppliers like Givaudan and Ernesto Ventos represent the first category, maintaining production facilities while also engaging in direct distribution to end users. They typically focus on large-volume customers and long-term supply agreements, leveraging their manufacturing control to ensure supply security and consistent quality. Chinese 2-acetylpyridine suppliers maintain dominant positions in terms of volume supply, with major companies leveraging their proximity to manufacturing bases to offer competitive pricing and flexible supply terms. They have increasingly invested in international market development, establishing overseas offices and developing direct relationships with major end users.
Sinofi is a bulk 2-acetylpyridine supplier in China, and we have a warehouse with 1,200 square meters for high-quality 2-acetyl pyridine. We sell different grades of 2-acetylpyridine at wholesale prices to e-liquid, pharmaceutical, food, flavour, and fragrance manufacturers.

Supply Chain of 2-Acetylpyridine

The 2-acetylpyridine supply chain represents a sophisticated network spanning multiple continents, industries, and operational models, characterized by concentrated upstream production and diverse downstream applications. This specialty chemical’s journey from raw material extraction to final application encompasses complex interdependencies between chemical manufacturers, distributors, logistics providers, and end users across the pharmaceutical, agrochemical, and flavour industries.

Fundamental Supply Chain Architecture

The 2-acetylpyridine supply chain exhibits a characteristic hourglass structure, with multiple raw material sources converging at relatively few manufacturing points before diverging again through distribution networks to reach diverse end markets. This configuration creates critical bottlenecks at the manufacturing stage, where technical expertise, capital investment, and regulatory approvals create significant barriers to entry. The concentration of production capacity in specific geographic regions further amplifies these structural constraints, making the entire chain vulnerable to localized disruptions.
At the apex of the supply chain, raw material suppliers provide the essential inputs for 2-acetylpyridine synthesis, primarily pyridine and acetylating agents such as acetic anhydride or acetyl chloride. These materials themselves derive from complex supply chains, with pyridine production concentrated in facilities that process coal tar or are synthesized from simpler petrochemical feedstocks. The availability and pricing of these raw materials significantly influence the entire downstream supply chain, creating cascading effects that ultimately impact end-user costs and availability.
The manufacturing tier represents the supply chain’s critical transformation point, where chemical synthesis converts raw materials into the finished product. This stage typically involves a limited number of specialized producers, predominantly located in China and India, who possess the technical capabilities, production infrastructure, and regulatory approvals necessary for commercial-scale production. These manufacturers often operate within integrated chemical complexes that provide economies of scale and scope, enabling efficient production while managing the complexities of hazardous material handling and waste treatment.
The distribution tier expands the supply chain’s reach from concentrated production points to dispersed global markets. This expansion occurs through multiple channels, including direct sales from manufacturers to large end users, distribution through global chemical distributors, and intermediation by regional specialty suppliers. Each channel serves specific market segments and customer requirements, with the selection influenced by factors including order volumes, technical support needs, regulatory requirements, and risk management considerations.

Wholesale and Buy 2-Acetylpyridine in Bulk

The procurement of 2-acetylpyridine in wholesale and bulk quantities demands sophisticated approaches that integrate market intelligence, supplier relationship management, risk mitigation, and cost optimization. 2-Acetylpyridine buyers should move beyond transactional purchasing to develop strategic capabilities that create competitive advantage through superior supply chain performance. The complexity of the 2-acetylpyridine market, with its concentrated production, diverse applications, and regulatory requirements, rewards organizations that invest in developing deep market knowledge and strong supplier relationships. Purchasing managers must navigate these complexities while managing internal stakeholder expectations, budget constraints, and risk management requirements.

Understanding Market Dynamics and Pricing Structures

The wholesale market for 2-acetylpyridine exhibits distinct pricing dynamics that purchasing managers must understand to optimize procurement outcomes. Pricing structures typically follow a tiered model based on purchase volumes, with significant discounts available for bulk quantities exceeding certain thresholds. These thresholds vary by supplier but generally begin at drum quantities of 200 kilograms, with additional price breaks at one metric ton, five metric tons, and container load quantities. Understanding these pricing tiers and their relationship to your organization’s consumption patterns enables strategic volume aggregation and timing decisions that can substantially reduce total costs.
Long-term pricing agreements offer potential advantages but require careful structuring to balance risk and opportunity. Fixed pricing provides budget certainty but may result in opportunity losses during declining markets. Indexed pricing formulas that adjust based on raw material costs or market indicators provide flexibility but require robust governance mechanisms to ensure transparent and fair adjustments. The selection of pricing mechanisms should align with organizational risk tolerance, market outlook, and internal budgeting processes.

Supplier Evaluation and Selection Criteria

The evaluation and selection of 2-acetylpyridine suppliers demands a comprehensive assessment across multiple dimensions beyond simple price comparison. Quality capabilities represent a fundamental evaluation criterion, with suppliers requiring demonstrated ability to consistently meet specifications for purity, impurity profiles, and physical characteristics. This assessment should encompass not only current quality performance but also quality system robustness, including documentation practices, change control procedures, and deviation management capabilities. The sophistication of suppliers’ analytical capabilities, particularly for trace impurity detection and characterization, becomes critical for pharmaceutical applications where regulatory requirements demand comprehensive impurity understanding. Supply reliability and capacity considerations significantly influence supplier selection decisions. Evaluation should encompass production capacity relative to your requirements, including the ability to accommodate demand growth and seasonal variations.

As a bulk 2-acetylpyridine manufacturer and supplier in China, we supply high-quality 2-acetyl pyridine for e-liquid, pharmaceutical, food, flavour, and fragrance industries. We also wholesale 2-acetyl pyridine to small customers. Normally, they want to buy 2-acetylpyridine in small quantities. To serve them, we can wholesale 2-acetylpyridine at bulk prices and provide a one-stop purchasing service.

2-Acetylpyridine Prices (USD/Kg)

Food Grade 2-Acetyl Pyridine Prices (GC Content >=99.0%)

VolumeUnit PriceShipment
50g19 USDExpress
500g95 USDExpress
1Kg135 USD/KgExpress
20Kg>20% cheaperExpress
100Kg-AbovenegotiableExpress / Sea

The 2-acetylpyridine prices have undergone a fundamental transformation from relatively predictable patterns to a complex, volatile environment requiring sophisticated analysis and management approaches. The convergence of concentrated supply, growing demand, and increasing supply chain complexity creates persistent pricing pressure with substantial volatility risk.
Market pricing for 2-acetylpyridine demonstrates correlation with several factors that procurement professionals must monitor. Raw material costs, particularly pyridine prices, directly influence product pricing with typical lag times of two to three months. Energy costs impact production economics, particularly for manufacturers relying on energy-intensive synthesis routes. Currency fluctuations affect import pricing, with the US dollar to Chinese yuan exchange rate particularly relevant given China’s dominant production position. Seasonal demand patterns from flavour and fragrance applications can create predictable price fluctuations that astute purchasers can exploit through strategic timing of purchases.
The relationship between spot and contract pricing has evolved significantly, with increased volatility creating larger differentials than historically observed. Contract prices negotiated through annual agreements typically provide fifteen to twenty-five percent discounts versus spot market pricing, though these agreements increasingly incorporate adjustment mechanisms reflecting raw material cost changes. The security of supply associated with contract arrangements commands increasing value, with many purchasers accepting premium pricing for guaranteed availability during tight market conditions.
Furthermore, the above price quotations of 2-acetylpyridine do not include the express shipping fee. The reason is that the shipment cost may exceed the value of the sample. However, the bulk wholesale prices of 2-acetylpyridine will be much lower than those of small orders. Please contact us for more details.

2-Acetylpyridine Specification

Appearance:White to light yellow, clear liquid
Odor:Tobacco-like, popcorn, heavy-oily-fatty aroma
Purity (GC)>=99%
Specific Gravity(25°C/25°C)1.077 – 1.084
Refractive Index (20°C/D)1.518 – 1.524
Arsenic (mg/Kg)<=3.0
Heavy Metal (as Pb, mg/Kg)<=10.0

2-Acetylpyridine Uses

2-Acetylpyridine serves as a versatile chemical compound with applications spanning multiple industries, from pharmaceutical synthesis to flavour creation and advanced materials development. This heterocyclic ketone, characterized by its distinctive popcorn-like aroma and reactive chemical structure, has established itself as an essential building block in the modern chemical industry.

Pharmaceutical and Medicinal Chemistry Applications

The pharmaceutical industry represents one of the most significant application areas for 2-acetyl pyridine, where it serves primarily as a key intermediate in the synthesis of various drug molecules. Its role in pharmaceutical chemistry extends beyond simple building block functionality to encompass sophisticated synthetic transformations that enable the construction of complex molecular architectures. The pyridine moiety provides a privileged scaffold frequently found in bioactive molecules, while the acetyl group offers a reactive handle for further functionalization.
In antituberculosis drug synthesis, 2-acetyl pyridine plays a crucial role in developing compounds that combat drug-resistant strains of Mycobacterium tuberculosis. The compound serves as a starting material for synthesizing thiosemicarbazone derivatives, which have demonstrated significant antimycobacterial activity. These derivatives work by interfering with bacterial cell wall synthesis and have shown promise in addressing the growing challenge of multidrug-resistant tuberculosis. Research continues to explore structural modifications of these 2-acetylpyridine-derived compounds to enhance their efficacy and reduce potential side effects.
The role of 2-acetyl pyridine in synthesizing anticancer agents continues to expand as researchers discover new molecular targets and therapeutic strategies. The compound enables the construction of kinase inhibitors, topoisomerase inhibitors, and other classes of anticancer drugs that interfere with tumor cell proliferation and survival. The versatility of 2-acetylpyridine as a synthetic intermediate allows medicinal chemists to explore diverse structural modifications in their quest for more effective and selective cancer treatments. Structure-activity relationship studies have revealed how subtle changes to 2-acetylpyridine derivatives can dramatically impact their anticancer properties.

Flavour and Fragrance Industry Applications

The flavour and fragrance industry extensively utilizes 2-acetylpyridine for its distinctive organoleptic properties that contribute to creating authentic and appealing sensory experiences. At appropriate dilutions, the compound imparts a characteristic nutty, popcorn-like aroma that has become indispensable in certain flavour profiles. This application leverages not the chemical reactivity of 2-acetyl pyridine but rather its ability to interact with human olfactory and gustatory receptors to produce specific sensory perceptions.
In popcorn flavouring, 2-acetylpyridine serves as a critical component that authentically recreates the aroma of freshly popped corn. The compound works synergistically with other flavouring agents such as diacetyl and various butter notes to produce the complex sensory profile associated with buttered popcorn. Flavour chemists carefully balance 2-acetylpyridine concentrations to achieve the desired intensity without overwhelming other flavour components. The compound’s low odor threshold means that even trace amounts can significantly impact the overall flavour profile, requiring precise formulation and quality control.
Bakery applications represent another significant use area where 2-acetyl pyridine contributes to the complex aroma profiles of bread crusts, crackers, and other baked goods. Nut flavour formulations frequently incorporate 2-acetyl pyridine to enhance roasted characteristics in peanut, almond, and hazelnut flavours. The compound contributes to the complex flavour profile that develops during nut roasting, where heat-induced chemical reactions produce numerous aromatic compounds.
Rice and grain flavours benefit from 2-acetylpyridine’s ability to impart cooked cereal notes that enhance authenticity in processed foods. The compound naturally occurs in cooked rice, particularly aromatic varieties like basmati and jasmine, where it contributes to their distinctive fragrance. Food manufacturers incorporate 2-acetylpyridine in instant rice products, rice-flavoured snacks, and ready-to-eat meals to provide the sensory cues consumers associate with freshly cooked rice. The compound’s effectiveness at low concentrations makes it economically viable for large-scale food production while maintaining label-friendly ingredient lists.

Agrochemical and Crop Protection Applications

The agrochemical industry utilizes 2-acetylpyridine as an intermediate in synthesizing various crop protection agents, where its chemical structure enables the construction of molecules with pesticidal, herbicidal, or fungicidal activity. The pyridine ring system frequently appears in agrochemical active ingredients due to its favorable properties, including environmental stability, biological activity, and synthetic accessibility. The acetyl group provides additional functionality that enables further derivatization to optimize biological activity and environmental fate.

Chemical Synthesis and Industrial Intermediates

Beyond its direct applications, 2-acetyl pyridine serves as a valuable intermediate in synthesizing numerous other chemical compounds used across various industries. Its bifunctional nature, containing both a basic nitrogen atom and a reactive carbonyl group, enables participation in diverse chemical transformations. This versatility has established 2-acetyl pyridine as a workhorse molecule in synthetic chemistry, facilitating the production of compounds that might otherwise require more complex or expensive synthetic routes.

2-Acetylpyridine in E-liquid and Vaping Products

2-Acetylpyridine is used to create popcorn and roasted nut flavour profiles in food products and has been adopted by the vaping industry for similar purposes. The chemical appears alongside related compounds such as 3-acetylpyridine and various pyrazine derivatives in flavoured e-liquids. The compound has been identified in multiple commercial e-cigarette products, particularly those with nutty, coffee, tobacco, or dessert-style flavour profiles.

Regulatory Context and Industry Response

The presence of 2-acetylpyridine in vaping products occurs within a broader regulatory landscape concerning flavouring chemicals in e-cigarettes. While compounds like diacetyl have received significant regulatory attention due to their association with bronchiolitis obliterans, 2-acetylpyridine has not been subject to the same level of specific regulatory prohibition.
The Flavour and Extract Manufacturers Association (FEMA) has evaluated 2-acetylpyridine for use in food products, but these evaluations primarily consider ingestion rather than inhalation exposure. The distinction between safety for consumption versus inhalation remains a critical consideration, as compounds deemed safe for eating may present different risks when inhaled directly into the lungs.

Current Market Presence

Analysis of commercial e-liquids reveals that 2-acetylpyridine continues to appear in various products, often as part of complex flavour formulations. The compound frequently occurs alongside other pyridine and pyrazine derivatives, creating layered flavour profiles that appeal to consumers seeking specific taste experiences. Products marketed as having tobacco, coffee, nutty, or caramel notes are more likely to contain this ingredient.

2-Acetylpyridine Benefits

2-Acetylpyridine presents substantial benefits across multiple industrial sectors, offering unique chemical properties and functional characteristics that address critical challenges in pharmaceutical development, food technology, chemical synthesis, and materials science.

Pharmaceutical Development Advantages

The pharmaceutical industry derives significant benefits from 2-acetyl pyridine’s role as a versatile building block in drug synthesis, where it enables efficient construction of complex molecular architectures essential for therapeutic activity. The compound’s bifunctional nature, combining a basic pyridine nitrogen with a reactive acetyl group, provides synthetic chemists with multiple options for molecular modification and optimization. This versatility translates into reduced development timelines and lower costs for bringing new medications to market, ultimately benefiting patients through improved access to innovative therapies.

Food Industry and Flavour Enhancement Benefits

The food and flavour industry realizes substantial benefits from 2-acetyl pyridine’s unique organoleptic properties, which enable the creation of authentic and appealing flavour profiles that enhance consumer satisfaction. The compound’s distinctive, nutty, popcorn-like aroma provides flavour chemists with a powerful tool for recreating complex sensory experiences that would otherwise require expensive natural extracts or complex formulations. This capability enables food manufacturers to deliver consistent, high-quality products that meet consumer expectations while managing production costs effectively.

Environmental and Sustainability Benefits

Environmental advantages of 2-acetyl pyridine include its biodegradability under appropriate conditions and well-understood environmental fate, which reduces concerns about persistent environmental contamination. The compound’s degradation pathways have been studied extensively, providing confidence that proper waste management practices can minimize environmental impact.

2-Acetylpyridine Used in Flavour and Fragrance

2-Acetylpyridine stands as one of the most distinctive and valuable aroma compounds in the flavour and fragrance formulator’s palette, offering unique sensory characteristics that have become indispensable for creating authentic and appealing products. The sensory profile of 2-acetylpyridine exhibits remarkable complexity despite its relatively simple structure. At threshold levels, typically between 0.02 and 0.06 parts per million in aqueous systems, the compound imparts subtle nutty and grain-like notes that enhance overall flavour complexity without dominating the profile. As concentrations increase to the range of 0.1 to 1 ppm, the characteristic popcorn and roasted corn notes become prominent, providing the authentic character sought in many snack and cereal applications. At higher levels, approaching 5 to 10 ppm, the compound can contribute bread crust and cracker-like notes, though careful attention must be paid to avoid overwhelming medicinal or astringent characteristics that emerge at excessive concentrations.
The temporal aspects of 2-acetylpyridine’s sensory impact deserve careful consideration in formulation work. The compound typically presents as a top-to-middle note in flavour applications, with its impact perceived immediately upon consumption but diminishing relatively quickly compared to heavier molecular weight components. This temporal profile influences formulation strategies, particularly when seeking to create layered sensory experiences where 2-acetylpyridine provides initial impact followed by other flavour components that sustain the overall perception.

Applications in Savory Flavour Systems

The application of 2-acetyl pyridine in savory flavour systems represents its most widespread and impactful use in the food industry. In popcorn flavouring, the compound serves as the cornerstone ingredient that authentically recreates the aroma of freshly popped corn. Optimal formulations typically employ 2-acetyl pyridine at levels between 10 and 50 ppm in the concentrated flavour, which translates to 0.5 to 2.5 ppm in the finished snack product. The compound works synergistically with diacetyl and acetylpropionyl to create the buttery notes associated with theater-style popcorn, while interaction with furanones and lactones adds depth and richness to the profile.

Formulation Challenges and Solutions

The formulation of products containing 2-acetylpyridine presents several technical challenges that require sophisticated approaches to ensure product quality and stability. The compound’s potent sensory impact necessitates precise dosing and thorough homogenization to avoid hot spots or inconsistent flavour distribution in finished products. This challenge becomes particularly acute in dry applications where achieving uniform distribution at parts-per-million levels requires specialized blending techniques and carriers that ensure adequate dispersion.

Synergistic Effects and Flavour Interactions

The interaction between 2-acetylpyridine and other flavour compounds creates opportunities for developing complex and appealing sensory profiles that exceed the sum of individual components. The synergy between 2-acetylpyridine and diacetyl in popcorn flavours exemplifies this effect, where the combination creates a more authentic and appealing profile than either compound alone. This interaction extends beyond simple addition, with the presence of 2-acetylpyridine modifying the perception of diacetyl to create rounder, more complex buttery notes.

A Tobacco Flavouring Using 2-Acetylpyridine

Include the following ingredients (Total 100g, unit: g):
Guaiacol, 1.77; Furaneol, 10.52; Angelica lactone, 2.76; 4-Vinylguaiacol, 3.52; 2-Acetylpyridine, 1.72; 2-Ethyl-6-methyl-pyrazine, 2.40; 4-Methylguaiacol, 1.53; Gamma-Valerolactone, 0.13; 4-Ethylguaiacol, 0.37; Methyl cyclopentenolone, 2.77; Ethyl cyclopentenolone, 2.51; Solvent, 70.

The weight percentage composition of the solvent components is: ethanol 70%, propylene glycol 10%, and glycerin 20%.

In conclusion, the diverse applications of 2-acetylpyridine demonstrate how a single chemical compound can impact multiple industries and contribute to solving various technical challenges. From life-saving pharmaceuticals to everyday food flavours, from crop protection agents to advanced materials, this versatile molecule continues to find new uses as scientific understanding and technical needs evolve. Sinofi Ingredients is an official chemical vendor of PubChem. As a bulk 2-acetylpyridine manufacturer and supplier in China, we sell different grades of 2-acetylpyridine at wholesale prices to large manufacturers and small customers worldwide.

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