This section focuses on an overview of cooling agent WS-5 or Symcool WS-5, as well as its manufacturing processes and uses. Also, please check out the introduction to Symcool WS-5 manufacturers, supply chain issues, cooling agent WS-5 suppliers, and WS-5 prices. Sinofi can help you buy high-quality WS-5 powder in bulk for your industry applications at wholesale prices based on FEMA 4309 and CAS 68489-14-5.
Table of Contents
What is Cooling Agent WS-5?
WS-5, or N-((Ethoxycarbonyl)methyl)-p-menthane-3-carboxamide, is an advanced synthetic cooling agent that has revolutionized various industries with its powerful cooling properties. Unlike natural cooling agents such as WS-23 and WS-3, WS-5 delivers a more intense and longer-lasting cooling sensation, making it particularly versatile for product formulations. WS-5 belongs to the family of carboxamide cooling agents, specifically designed to trigger the TRPM8 cold receptors in human skin and mucous membranes. With a cooling power approximately 25-35 times more potent than menthol, WS-5 can deliver significant cooling effects at much lower concentrations. The European Food Safety Authority (EFSA) has evaluated the safety of WS-5 for use as a flavouring agent. According to the U.S. Food and Drug Administration (FDA), WS-5 is approved to be used in the food and pharmaceutical industries. IFRA and the Research Institute for Fragrance Materials (RIFM) provide a guideline to ensure the cooling agent WS-5 is safe for its intended uses in food, pharmaceutical, and personal care industries. It has also been evaluated by relevant regulatory authorities like JECFA, EUR-Lex, and ECHACHEM.
Key Characteristics
- Heat resistance: WS-5 can withstand temperatures up to 200°C without losing its cooling properties, making it suitable for baking and high-temperature processing.
- Long-lasting effect: The cooling sensation can persist for 15-30 minutes, significantly longer than many competing cooling agents.
- High potency: Effective at low concentrations (30-100mg/kg), making it cost-efficient.
- Solubility: Soluble in ethanol, propylene glycol, and vegetable oils, but less soluble in water.
Comparison with Other Cooling Agents
Symcool WS-5 is part of a family of cooling agents, each with distinct properties:
- WS-5 vs. WS-3: WS-5 tends to provide a stronger, sometimes more overpowering cooling effect compared to WS-3.
- WS-5 vs. WS-23: WS-23 is more water-soluble and offers a cooling effect without a minty flavour, while WS-5 is one of the strongest cooling agents with a more powerful effect.
- WS-5 vs. Menthol: WS-5 can provide a cooling effect up to 5 times stronger than menthol without the characteristic mint flavour.
CAS No.: 68489-14-5
According to the American Chemical Society, the CAS number of WS-5 (N-((Ethoxycarbonyl)methyl)-p-menthane-3-carboxamide) is 68489-14-5.
Molecular Formula: C15H27NO3
Molecular Mass: 269.38
Appearance: White powder.
Solubility: Easily soluble in alcohol, propylene glycol; Inoluble in water, 9.51 mg/L @ 25 °C (est)
Other Names:
♦ WS 5
♦ Symcool WS-5
♦ Cooling Sensate WS 5
♦ N-[[(1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]carbonyl]glycine ethyl ester
FEMA Number 4309
According to the Flavor and Extract Manufacturers Association of the United States (FEMA), the cooling agent WS-5’s number is FEMA 4309.
Bulk Symcool WS-5 Manufacturers
Top cooling agent WS-5 manufacturers like Symrise and some Chinese companies have invested significantly in expanding their cooling compound portfolio, with WS-5 being one of its premium offerings. Symrise has established itself as a primary manufacturer of cooling agents. The company’s extensive research and development capabilities have helped position it as an innovation leader in cooling technology.
Sinofi is a bulk cooling agent WS-5 manufacturer in China, and we have a manufacturing facility with 2,500 square meters for the production of WS-5 cooling agent. We supply high-quality WS-5 powder at bulk prices and serve the food, pharmaceutical, cosmetics, and personal care industries worldwide.
Manufacturing Process of Symcool WS-5
The manufacturing process of cooling agent WS-5 involves precise chemical synthesis and purification steps that require careful control of reaction conditions.
Manufacturing Process
- Menthol (Compound 1), pyridine, and acetone are mixed to obtain a mixed solution; a chloramine reagent solution is added dropwise to the mixed solution, and the reaction is continued after the addition is completed to obtain menthone (Compound 2).
- The tetrahydrofuran solution of menthone and potassium tert-butoxide is mixed, and p-methylbenzenesulfonylmethyl isonitrile is added to the mixed solution for reaction to obtain nitrile menthol (Compound 3);
- The nitrile menthol is dissolved in hydrochloric acid and reacted to obtain menthyl formic acid (Compound 4);
- Menthyl formic acid, glycine ethyl ester, pyridine, and ethyl acetate are mixed to obtain a mixed solution. A condensation reagent solution is added to the mixed solution, and the reaction is carried out. and hydrochloric acid is added dropwise to the reaction system, and the reaction is continued to obtain menthyl amide cooling agent WS-5.
Quality manufacturers implement rigorous testing protocols, including high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS), to verify purity levels and identify potential impurities.
Purification Process
Once the reaction is complete, the crude product undergoes several purification steps:
- Washing with aqueous solutions to remove unreacted materials and by-products.
- Drying of the organic phase using drying agents.
- Concentration of the organic phase through solvent evaporation.
- Crystallization to obtain pure WS-5 crystals.
- Filtration and drying of the crystals under controlled conditions.
As demand for this powerful cooling agent continues to grow across multiple industries, ongoing innovations in its production processes aim to improve efficiency, sustainability, and cost-effectiveness.
Bulk Cooling Agent WS-5 Suppliers
Symrise and Chinese WS-5 suppliers have established themselves as major suppliers in the global market. They have invested in large-scale production facilities that enable competitive pricing while maintaining quality standards. Their advantages include:
- Large production capacity
- Competitive pricing structures
- Established export networks
- Various purity grades available (97-99.5%)
Sinofi is a bulk cooling agent WS-5 supplier in China, and we have a warehouse with 1,200 square meters for high-quality cooling agent WS-5. We sell different grades of WS-5 powder at wholesale prices to food, pharmaceutical, cosmetics, and personal care manufacturers.
Supply Chain of Symcool WS-5
Production and Raw Material Sourcing
The WS-5 supply chain begins with the procurement of key chemical precursors, primarily derivatives of menthane and specific carboxamide compounds.
Primary production is concentrated in a handful of chemical manufacturing hubs:
- China’s eastern coastal regions, particularly around Shanghai.
- Western European speciality chemical clusters, notably in Germany and Switzerland.
- Select facilities in the United States and Japan.
Manufacturing Process and Capacity
Global production capacity is dominated by a small number of major chemical manufacturers who possess the necessary technical expertise and regulatory approvals. The limited number of qualified producers creates potential bottlenecks in the supply chain, particularly during periods of high demand.
Distribution Networks
Once manufactured, WS-5 moves through a tiered distribution system:
- Primary Distribution: Bulk quantities are shipped directly from manufacturers to large flavour and fragrance houses or major consumer product companies.
- Secondary Distribution: Regional chemical distributors who purchase larger quantities and repackage for smaller customers.
- Formulation Specialists: Companies that incorporate WS-5 into specific flavour systems or functional blends.
End Market Applications
The final stage of the WS-5 supply chain involves incorporation into consumer-facing products:
- Oral care products (toothpaste, mouthwash).
- Confectionery (candies, chewing gum).
- Beverages (energy drinks, flavoured waters).
- Pharmaceutical applications (throat lozenges, topical analgesics).
- Personal care products (cosmetics, after-shave).
Each application requires different formulation expertise and may involve separate supply chain branches with specialized knowledge of the cooling agent’s behavior in different product matrices. As consumer preference for cooling sensations in various products continues to grow, the WS-5 supply chain is likely to see further refinement and expansion to meet global demand efficiently.
Wholesale and Buy WS-5 in Bulk
For cooling agent WS-5 buyers, bulk purchasing represents a strategic advantage. The superior cooling properties, cost savings, and supply chain benefits make wholesale purchasing an attractive option for manufacturers across multiple industries. By carefully selecting qualified suppliers, understanding technical requirements, and negotiating favourable terms, WS-5 buyers can secure a reliable supply of this valuable ingredient while maximizing cost efficiency.
When sourcing WS-5 cooling agent in bulk, you should prioritize suppliers that meet these criteria:
- Quality control documentation
- Technical support capabilities
- Consistent product specifications
- Reliable delivery schedules
As a bulk manufacturer and supplier of WS-5 cooling agent in China, we supply high-quality WS-23 coolant for food, pharmaceutical, cosmetics, and personal care industries. We also wholesale WS-5 to small customers. Normally, they want to buy WS-5 powder in small quantities. To serve them, we can wholesale cooling agent WS-5 at bulk prices and provide a one-stop purchasing service.
Cooling Agent WS-5 Prices (USD/Kg)
Food Grade Cooling Agent WS-5 Prices (purity >=99.0%)
| Volume | Unit Price | Shipment |
| 50g | 18 USD | Express |
| 500g | 126 USD | Express |
| 1Kg | 180 USD/Kg | Express |
| 20Kg | 30% cheaper | Express |
| 100Kg-Above | negotiable | Express / Sea |
The cooling agent WS-5 prices have seen significant movements in recent months, drawing attention from manufacturers in the food, beverage, and personal care industries. Major flavour and fragrance companies have responded to these price movements with various strategies. Some have secured long-term supply agreements with WS-5 manufacturers, while others are exploring alternative cooling agents or blend formulations to maintain cost efficiency. The market outlook suggests continued price sensitivity, with potential stabilization dependent on expanded production capacity expected to come online from several Asian manufacturers.
Furthermore, the above price quotations of WS-5 cooling agent, especially for small orders, do not include the express shipping fee. The reason is that the shipment cost of WS-5 coolant may exceed the value of the sample. However, the bulk wholesale WS-5 prices will be much lower than those of small orders. Please contact us for more details.
Cooling Agent WS-5 Uses
Food and Beverage Uses
WS-5 has found extensive applications in the food and beverage industry, where a cooling or refreshing sensation is desired:
Confectionery Products
- Candies, chocolates, and chewing gum benefit from the long-lasting cooling effect without flavour interference.
- Mints and breath fresheners gain enhanced cooling properties.
Beverages
- Alcoholic beverages, including beer and spirits, use WS-5 to provide a crisp, refreshing finish.
- Soft drinks and energy drinks with cooling sensations.
- Dairy products like flavoured milk and yogurts to enhance sensory experiences.
Other Food Uses
- Ice creams and frozen desserts: WS-5 can enhance other flavours when used in combination, creating unique sensory experiences
Personal Care and Cosmetic Uses
The cooling properties of WS-5 make it valuable in personal care products:
Oral Care
- Toothpastes and mouthwashes benefit from WS-5’s clean cooling sensation without a strong minty taste.
- Breath fresheners and oral sprays.
Skincare Products
After-sun lotions and moisturizers for a soothing effect
- Lip balms and lip glosses for a gentle cooling effect
- Facial masks and cleansers
Hair and Body Products
- Shampoos, shower gels, and sunscreen formulations.
- Shaving creams for a refreshing feel.
Pharmaceutical Uses
In the pharmaceutical industry, WS-5 serves several important functions:
Topical Medications
- Pain relief creams and ointments (anti-inflammatory products).
- Antipruritic (anti-itch) formulations.
Oral Medications
- Cough syrups and lozenges (referred to as “linctus” in some sources).
- Oral cavity pain relievers.
- Medications for dyspepsia (indigestion).
- Heat stroke prevention and treatment formulations.
Safety and Regulatory Status
WS-5 is generally considered safe for consumption by regulatory agencies like the FDA and EFSA. However, proper usage guidelines should be followed:
- The acceptable daily intake (ADI) has been established at 0-0.2 mg/kg body weight per day by the Joint FAO/WHO Expert Committee on Food Additives (JECFA).
- Overuse can potentially lead to a numbing or desensitizing effect.
- Recommended usage concentrations vary by application but typically range from 0.5-1.5%.
As consumer demand for novel sensory experiences continues to grow, WS-5’s versatility ensures its continuing importance in product development and formulation.
Cooling Agent WS-5 Benefits
This synthetic compound offers several advantages over traditional cooling ingredients like menthol, making it increasingly popular in various consumer products.
Superior Cooling Profile
WS-5 delivers a clean, long-lasting cooling sensation without the bitter or medicinal taste often associated with menthol. Its cooling effect is both more intense and more persistent than traditional alternatives, providing a refreshing experience that consumers appreciate in oral care products, confectionery, and beverages.
Greater Stability
One of WS-5’s most valuable properties is its exceptional stability across diverse formulation conditions:
- Heat resistant: Maintains its cooling properties even when exposed to high temperatures during manufacturing processes.
- pH stable: Functions effectively in both acidic and alkaline environments.
- Compatible with a wide range of other ingredients.
- Longer shelf life than many alternative cooling agents.
Versatility in Applications
WS-5’s unique properties make it suitable for an impressive range of consumer products.
Enhanced Sensory Experience
Beyond simple cooling, WS-5 contributes to multidimensional sensory experiences. When properly formulated, it can:
- Enhance flavour perception and extend taste experiences.
- Create a refreshing mouth feel that consumers associate with cleanliness.
- Mask unpleasant flavours in medicinal or functional products.
- Provide a distinctive sensory signature for branded products.
Lower Usage Levels
WS-5’s potency means manufacturers can achieve desired cooling effects using significantly lower concentrations compared to traditional cooling agents. This translates to:
- Cost savings in formulations.
- Less potential for unwanted flavour interactions.
- Reduced risk of sensory fatigue in consumers.
WS-5 Used in E-cigarette
A Cooling Agent for E-cigarette Liquid
Weigh 6.4 parts WS-23, 1.6 parts WS-3, 1 part WS-12, and 1 part WS-5, respectively. Mix the above components evenly, then take 10 parts of propylene glycol, stir and dissolve, and obtain a cooling agent for e-vaping liquid. The cooling agent of this formula has the best coolness, mildness, uniformity, durability, and length.
In conclusion, cooling agent WS-5 represents an important advancement in sensory enhancement technology. Its unique combination of powerful cooling properties without flavour alteration makes it an invaluable ingredient across food, personal care, and pharmaceutical industries. As a bulk cooling agent WS-5 manufacturer and supplier in China, we sell different grades of Symcool WS-5 powder at wholesale prices to large manufacturers and small customers worldwide.