This section focuses on an overview of cooling agent WS-3 (Menthol Carboxamide or Symcool WS-3) as well as its manufacturing processes and uses. Also, please check out the introduction to menthol carboxamide WS-3 manufacturers, supply chain issues, menthol carboxamide WS-3 suppliers, and menthol carboxamide WS-3 prices. Sinofi can help you buy high-quality Symcool WS-3 powder in bulk for your industry applications at wholesale prices based on FEMA 3455 and CAS 39711-79-0.

Table of Contents

What is Menthol Carboxamide WS-3?

Cooling agent WS-3, chemically known as menthol carboxamide or N-ethyl-p-menthane-3-carboxamide, is a synthetic compound that provides a cooling sensation without the minty flavor typically associated with menthol. WS-3 belongs to the family of carboxamides, and it works by activating the TRPM8 receptors in the skin and mucous membranes. Symcool WS-3 is virtually odorless and tasteless, making it particularly valuable when a cooling effect is desired without menthol’s characteristic mint flavor. WS-3 consists of a cyclohexane ring with ethyl, methyl, and isopropyl substituents, along with a carboxamide functional group. WS-3 and WS-23 are the main cooling agents in the e-liquid formula. The cooling sense of WS-3 is gentle and lasting, and is mainly concentrated at the tongue bottom and the throat. WS‑3 has a low coolness threshold and can bring a strong burst of coolness, laying the foundation for instant coolness for the compound cooling system. WS‑5 has high coolness intensity and long duration, and its chemical structure can stimulate cool receptors for a long time to maintain coolness. After WS‑23 provides an instantaneous coolness, it works synergistically with WS‑3 and WS‑5 to regulate the effect of coolness from an instant burst to long-lasting, effectively improving the quality and user experience of cool products. According to the U.S. Food and Drug Administration (FDA), menthol carboxamide WS-3 is approved to be used in the food, cosmetics, and pharmaceutical industries. It has also been evaluated by relevant regulatory authorities like JECFA, EUR-Lex, ECHACHEM, and WHO. WS-3 has been evaluated by the European Food Safety Authority (EFSA) as a flavoring substance. They evaluated its safety for use as a flavoring agent.

CAS No.: 39711-79-0

According to the American Chemical Society, the CAS number of menthol carboxamide WS-3 is 39711-79-0.
CAS Name: N-Ethyl-p-menthane-3-carboxamide
Molecular Formula: C13H25NO
Molecular Mass: 211.34
Appearance: White powder.
Solubility: Easily soluble in alcohol; Insoluble in water: 21.38 mg/L @ 25 °C (est).
Other Names:
WS-3 (amide)
Symcool WS-3
Ethyl menthane carboxamide
Cooling Sensate WS-3
N-Ethyl-p-menthanecarboxamide

FEMA Number 3455

According to the Flavor and Extract Manufacturers Association of the United States (FEMA), the FEMA number of menthol carboxamide WS-3 is 3455. IFRA provides a guideline in the IFRA Transparency List to ensure WS-3 uses in the food, pharmaceutical, and cosmetic industries.

Bulk Menthol Carboxamide WS-3 Manufacturers

The bulk menthol carboxamide WS-3 manufacturing landscape is dominated by several established companies with developed substantial manufacturing capabilities. Top menthol carboxamide WS-3 manufacturers like Symrise AG have specialized chemical manufacturing facilities for WS-3 and other cooling agents. These companies typically offer:

High purity levels (99%+).
Various particle sizes and formulations.
Comprehensive documentation and certificates of analysis.
Stability testing and shelf-life guarantees.

Sinofi is a bulk manufacturer of menthol carboxamide WS-3 in China, and we have a manufacturing facility with 2,500 square meters for the production of WS-3 cooling agent. We supply high-quality menthol carboxamide WS-3 at bulk prices and serve the food and beverage, pharmaceutical, cosmetics, and personal care industries worldwide.

Manufacturing Process of Symcool Menthol Carboxamide WS-3

The manufacturing of menthol carboxamide WS-3 represents a sophisticated chemical process requiring precise control and expertise.

Raw Material Preparation

The production of WS-3 begins with the procurement of high-quality raw materials:

L-menthol (or synthetic menthol)
Ethanolamine
Coupling reagents
Catalysts
Purification solvents

Each material undergoes rigorous quality control testing before entering the manufacturing process to ensure product consistency and purity.

Synthesis Process

Step 1: Esterification

The initial reaction involves the conversion of menthol to menthyl chloride or another activated intermediate. This typically occurs in the presence of thionyl chloride or similar reagents in a temperature-controlled reactor.

Step 2: Amidation Reaction

The activated menthol derivative reacts with ethanolamine in a coupling reaction. This critical step requires:

Precise temperature control (typically 40-60°C)
Inert atmosphere (nitrogen blanket)
Continuous stirring
Catalyst systems to improve reaction efficiency

Step 3: Neutralization

The reaction mixture undergoes neutralization to remove acidic by-products, often using sodium bicarbonate or similar basic compounds.

Purification Process

Extraction and Washing

The crude product undergoes multiple extraction steps using suitable organic solvents. The organic phase is washed several times to remove impurities and residual reagents.

Crystallization

WS-3 crystallization is a carefully controlled process involving:

Precise cooling rates
Seeding with pure WS-3 crystals
Aging periods to maximize crystal growth
Filtration of crystal slurry

Drying and Milling

The wet crystals proceed to drying chambers where the moisture content is reduced to specification levels, typically below 0.5%. The dried product is then milled to achieve the desired particle size distribution.

As cooling agents continue to be in high demand for personal care, food, and pharmaceutical applications, optimizing the production process remains a focus for manufacturers seeking to improve efficiency and environmental performance.

Bulk Menthol Carboxamide WS-3 Suppliers

Large menthol carboxamide WS-3 manufacturers have established themselves as reliable bulk suppliers globally. Top WS-3 suppliers like Symrise AG stand out with dedicated production facilities and strict quality control protocols for high-purity WS-3 cooling agent. Chinese supplier have rapidly expanded their market shares by offering competitive pricing while maintaining consistent quality standards.
Sinofi is a bulk menthol carboxamide WS-3 supplier in China, and we have a warehouse with 1,200 square meters for high-quality WS-3 cooling agent. We sell different grades of menthol carboxamide WS-3 at wholesale prices for the food, pharmaceutical, cosmetics, and personal care industries.

Supply Chain of Symcool Menthol Carboxamide WS-3

The supply chain of menthol carboxamide WS-3 represents a complex network of suppliers, manufacturers, distributors, and stakeholders that work together to ensure the efficient production and delivery of WS-3 cooling agent, a popular synthetic cooling compound used in various consumer products.

Supply Chain Structure

The WS-3 supply chain follows a multi-tiered structure that can be broken down into several key components:

Raw Material Suppliers

Chemical precursor suppliers provide essential compounds like L-menthol.
Ethylamine suppliers for the amine component.
Solvent and catalyst suppliers for chemical processing.

Primary Manufacturers

Chemical manufacturers that convert raw materials into Symcool WS-3.
Quality control laboratories that test compound purity.

Secondary Processors and Formulators

Product formulators who incorporate Symcool WS-3 into final consumer goods.
Specialized packaging companies for consumer-ready products.
Flavor houses that create proprietary cooling blends.

Distributors and End Users

Consumer goods manufacturers (oral care, confectionery, pharmaceuticals).
Wholesale chemical distributors.
Retail outlets and e-commerce platforms.
End consumers.

As consumer preference for cooling sensations in products grows, the WS-3 supply chain will continue to adapt, balancing efficiency, sustainability, and regulatory requirements to meet global demand.

Wholesale and Buy Menthol Carboxamide WS-3 in Bulk

Strategic bulk purchasing of menthol carboxamide WS-3 can provide significant competitive advantages for buyers in the oral care, food, and personal care industries. By carefully selecting WS-3 wholesale suppliers and implementing effective inventory management practices, menthol carboxamide buyers can enhance both their operational efficiency and market position.

Key Considerations When Purchasing WS-3 in Bulk

When purchasing chemical ingredients in bulk, quality assurance is paramount. Reputable suppliers should provide:

Certificates of Analysis (CoA).
Purity specifications (typically 99% or higher for Symcool WS-3).
Safety Data Sheets (SDS).
Manufacturing date and batch information.

As a bulk manufacturer and supplier of menthol carboxamide WS-3 in China, we supply high-quality WS-3 cooling agent for food, pharmaceutical, cosmetics, and personal care industries. We also wholesale WS-3 powder to small customers. Normally, they want to buy menthol carboxamide WS-3 in small quantities. To serve them, we can wholesale menthol carboxamide WS-3 at bulk prices and provide a one-stop purchasing service.

Menthol Carboxamide WS-3 Prices (USD/Kg)

Food Grade Menthol Carboxamide WS-3 Prices (purity >=99.0%)

Volume	Unit Price	Shipment
50g	15 USD	Express
500g	104 USD	Express
1Kg	148 USD/Kg	Express
20Kg	30% cheaper	Express
100Kg-Above	negotiable	Express / Sea

The menthol carboxamide WS-3 prices have seen significant fluctuations in recent months, driven by supply chain disruptions and changing market demands.

Key Market Drivers

Several factors are influencing the current pricing landscape:

Raw material shortages affecting primary manufacturing hubs in East Asia.
Increased transportation and tariff costs due to ongoing shipping constraints.
Growing demand in personal care applications, particularly in cooling skincare products.
Regulatory changes impacting production costs.

Furthermore, the above price quotations of menthol carboxamide WS-3, especially for small orders, do not include the express shipping fee. The reason is that the shipment cost of W-23 may exceed the value of the sample. However, the bulk wholesale prices of menthol carboxamide WS-3 will be much lower than those of small orders. Please contact us for more details.

Menthol Carboxamide WS-3 Uses

Menthol carboxamide WS-3 has gained significant popularity across multiple industries.

Food and Beverage Uses

WS-3 has found extensive use in the food and beverage industry, particularly in:

Chewing gums and candies
Beverages and drink mixes
Breath fresheners
Dairy products
Alcoholic drinks

The compound’s ability to provide cooling without mint flavor makes it especially valuable in fruit-flavored products where mint notes would be undesirable.

Personal Care Uses

WS-3 is widely used in toothpastes, mouthwashes, and oral care products to create a refreshing cooling sensation. The compound’s stability makes it ideal for skincare products such as after-sun lotions, facial cleansers, and anti-aging creams, where it provides a pleasant cooling effect that helps soothe and refresh the skin.

Cosmetics Uses

In cosmetics, WS-3 is incorporated into lip balms, facial masks, and various beauty products to create a refreshing sensation that enhances the user experience. Its nearly odorless nature makes it compatible with fragrance systems without interference.

Pharmaceutical Uses

In pharmaceuticals, WS-3 serves multiple purposes:

Masking bitter tastes in medications.
Creating cooling sensations in topical analgesics.
Enhancing the sensory profile of cough drops and lozenges.
Contributing to the efficacy perception of certain formulations.

Regulatory Status and Safety

Menthol carboxamide WS-3 has been evaluated by regulatory bodies worldwide and is generally recognized as safe for its intended uses. The compound has been approved by:

FDA (US Food and Drug Administration) for use in food and cosmetics.
EFSA (European Food Safety Authority).
FEMA (Flavor and Extract Manufacturers Association) with GRAS status.

Typical usage levels range from 0.01% to 0.1%, depending on application, with higher concentrations permitted in specific products like chewing gum.
As consumer demand for unique sensory experiences grows, Symcool WS-3 is likely to continue gaining importance across multiple industries as a versatile cooling agent that offers distinct advantages over traditional alternatives.

Menthol Carboxamide WS-3 Benefits

Menthol carboxamide WS-3 offers several distinct benefits that make it valuable for both commercial and therapeutic applications.

Long-Lasting Cooling Effect

Unlike menthol, WS-3 provides a more persistent cooling sensation that doesn’t dissipate quickly. This extended effect makes it valuable in products where prolonged cooling is desired.

Odorless and Tasteless Properties

WS-3 delivers cooling without significant flavor or odor, allowing manufacturers to incorporate cooling sensations without altering the intended taste profile of their products.

Stability in Various Formulations

This cooling agent demonstrates excellent stability across different pH levels and temperatures, making it versatile for various manufacturing processes.

Lower Irritation Potential

Compared to some traditional cooling agents, WS-3 typically causes less irritation to mucous membranes and skin, making it suitable for sensitive applications.

Menthol Carboxamide WS-3 Used in E-cigarette Liquid

A Composition for Enhancing the Taste of E-cigarette Liquid and Vaping Flavor

The raw materials and their mass ratio are: Cooling Agent WS-3, 4 parts; Menthol, 4 parts; Rebaudioside A, 1 part; Ethyl Stearate, 5 parts; Adipic Acid, 5 parts; Propylene Glycol, 50 parts; and Ethanol, 31 parts.
Glycerin and propylene glycol are mixed in a mass ratio of 1:1 to obtain 9.6g of a mixed solution. Then 0.4g of the above composition is added to the mixed solution,
After being stirred evenly, it is injected into the electronic atomization device to obtain 10g of atomized flavor.

In conclusion, menthol carboxamide WS-3 offers manufacturers across multiple industries a valuable tool to create pleasant cooling sensations without the limitations of traditional menthol. Its stability, long-lasting effects, and neutral sensory profile make it particularly valuable for product developers seeking to enhance consumer experiences through controlled cooling effects. As a bulk manufacturer and supplier of Symcool WS-3 in China, we sell different grades of cooling agent WS-3 at wholesale prices to large manufacturers and small customers worldwide.