This section focuses on an overview of vanillin isobutyrate (Isobutavan) as well as its manufacturing processes and uses. Also, please check out the introduction to vanillin isobutyrate isobutavan manufacturers, supply chain issues, vanillin isobutyrate isobutavan suppliers, and vanillin isobutyrate isobutavan prices. Sinofi can help you buy high-quality vanillin isobutyrate isobutavan in bulk for your industry applications at wholesale prices based on FEMA 3754 and CAS 20665-85-4.
Table of Contents
What is Vanillin Isobutyrate (Isobutavan)?
Vanillin isobutyrate, commonly known by its trade name Isobutavan, is a synthetic flavor compound that has gained significant attention in the food, beverage, and fragrance industries. It appears as a colorless to slightly yellow liquid or solid, with a melting point around 27.0-31.0°C. Vanillin isobutyrate is formed by the esterification of vanillin with isobutyric acid. This ester derivative of vanillin combines the familiar vanilla character with unique buttery notes, creating a versatile ingredient used across multiple applications. Unlike natural vanillin, which can be somewhat water-soluble, vanillin isobutyrate has enhanced oil solubility and reduced water solubility. It offers improved heat stability and longer shelf life compared to natural vanillin, making it particularly valuable for baked goods and products requiring high-temperature processing. According to the U.S. Food and Drug Administration (FDA), vanillin isobutyrate is approved to be used in food, fragrance, and pharmaceutical industries. It has also been evaluated by relevant regulatory authorities like JECFA, EUR-Lex, ECHACHEM, RIFM, and WHO. The IFRA Transparency List provides a guideline to ensure the use of vanillin isobutyrate in food, fragrance, and pharmaceutical industries.
Sensory Profile and Flavor Characteristics
Isobutavan presents a complex flavor profile that maintains the familiar vanilla character but with additional nuances:
- Primary notes of rich, creamy vanilla.
- Secondary buttery, almost caramel-like undertones.
- Enhanced mouthfeel and flavor persistence compared to traditional vanillin.
- Lower volatility, providing a more sustained flavor release.
Flavor chemists particularly value Isobutavan for its ability to create fuller, more rounded flavor profiles when combined with other vanilla compounds. The isobutyrate modification imparts a subtle richness that enhances the perception of sweetness without adding sugar.
CAS No.: 20665-85-4
According to the American Chemical Society, the CAS number of vanillin isobutyrate (Isobutavan) is 20665-85-4.
CAS Name: Isobutavan
Molecular Formula: C12H14O4
Molecular Mass: 222.24
Solubility: Soluble in alcohols and oils, slightly soluble in water.
Other Names:
♦ Vanillin Isobutyrate
♦ Vanillyl Isobutyrate
♦ 3-Methoxy-4-Isobutyrylbenzaldehyde
♦ 4-Formyl-2-Methoxyphenyl 2-Methylpropanoate
♦ 4-Hydroxy-M-Anisaldehyde Isobutyrate
♦ 4-Hydroxy-M-Anisaldehyde 2-Methylpropionate
♦ 4-Hydroxy-3-Methoxybenzaldehyde Isobutyrate
♦ 4-Hydroxy-3-Methoxybenzaldehyde 2-Methylpropionate
♦ Propanoic Acid, 2-Methyl-, 4-Formyl-2-Methoxyphenyl Ester
♦ Isobutyric Acid, Ester With Vanillin
Vanillin Isobutyrate (Isobutavan) Odor
Sweet vanilla, creamy, fruity caramel chocolate.
FEMA Number 3754
According to the Flavor and Extract Manufacturers Association (FEMA), the number of vanillin isobutyrate (Isobutavan) is FEMA 3754.
Bulk Vanillin Isobutyrate (Isobutavan) Manufacturers
The global vanillin isobutyrate production is dominated by a handful of specialized chemical manufacturers that produce this compound in bulk quantities. Top vanillin isobutyrate isobutavan manufacturers like Givaudan produce this flavoring agent alongside their comprehensive portfolio of vanilla-inspired ingredients. They have developed proprietary processes that minimize impurities and optimize production efficiency.
Sinofi is a bulk manufacturer of vanillin isobutyrate in China, and we have a manufacturing facility with 2,500 square meters for the production of vanillin isobutyrate. We supply high-quality Isobutavan at bulk prices and serve food, fragrance, and pharmaceutical manufacturers worldwide.
Manufacturing Process of Vanillin Isobutyrate (Isobutavan)
The manufacturing of vanillin isobutyrate represents a sophisticated process that combines traditional chemical engineering with modern innovations.
Raw Materials
The primary ingredients required for vanillin isobutyrate synthesis include:
- Vanillin (4-hydroxy-3-methoxybenzaldehyde)
- Isobutyric anhydride
- Catalysts
- Solvents (toluene or other suitable organic solvents)
- Dehydrating agents
Manufacturing Process
In a vacuum environment and under nitrogen protection throughout the process, vanillin and isobutyric anhydride are mixed and subjected to a synthesis reaction under constant temperature conditions. After the sample is qualified, the unreacted isobutyric anhydride and isobutyric acid mixture is recovered by vacuum distillation, and the remaining product is further vacuum distilled to obtain vanillin isobutyrate with a gas phase analysis content greater than 98.5% and a yield greater than 90%.
As demand for natural-identical flavor compounds continues to grow, manufacturers are increasingly focused on developing more sustainable and efficient production methods while maintaining the high-quality standards required by the food and fragrance industries.
Bulk Vanillin Isobutyrate (Isobutavan) Suppliers
The bulk vanillin isobutyrate market is dominated by several established companies of flavors and fragrances. Top vanillin isobutyrate suppliers like Givaudan manufacture and supply high-purity vanillin derivatives, including isobutavan, at an industrial scale.
Sinofi is a bulk supplier of vanillin isobutyrate isobutavan in China, and we have a warehouse with 1,200 square meters for high-quality isobutavan. We sell different grades of vanillin isobutyrate at wholesale prices to food, fragrance, and pharmaceutical manufacturers.
Supply Chain of Vanillin Isobutyrate (Isobutavan)
Raw Material Sourcing
The production of vanillin isobutyrate begins with two key components: vanillin and isobutyric anhydride.
Vanillin Sources:
- Natural vanillin extracted from vanilla beans (primarily from Madagascar, Indonesia, and Mexico).
- Lignin-derived vanillin (byproduct of paper pulping).
- Guaiacol-based synthetic vanillin (petroleum derivative).
- Bioconversion-derived vanillin (from ferulic acid or eugenol).
Isobutyric Anhydride Sources:
- Petrochemical synthesis from propylene
Supply Chain Structure
The vanillin isobutyrate supply chain follows a multi-tiered structure:
Tier 1: Raw Material Suppliers
- Vanilla bean cultivators
- Forest product companies (lignin suppliers)
- Petrochemical companies
Tier 2: Chemical Manufacturers
- Companies producing vanillin from various precursors
- Producers of isobutyric acid
- Vanillin isobutyrate manufacturers
Tier 3: Flavor & Fragrance Companies
- Specialized manufacturers converting raw chemicals into flavor formulations
- Quality control and regulatory compliance experts
- Packaging and distribution specialists
Tier 4: End-Product Manufacturers
- Food and beverage companies
- Cosmetic and personal care producers
- Household product manufacturers
Tier 5: Distribution Channels
- Specialized chemical distributors
- Wholesale ingredient suppliers
- Direct business-to-business sales networks
As the flavor and fragrance industry continues to evolve, the supply chain for specialty ingredients like vanillin isobutyrate will need to balance cost-effectiveness, sustainability, and reliability to meet global demand.
Wholesale and Buy Vanillin Isobutyrate (Isobutavan) in Bulk
The wholesale procurement of vanillin isobutyrate represents a significant opportunity for manufacturers in the food, flavor, fragrance, and pharmaceutical industries. Bulk isobutavan buyers can secure this valuable ingredient at competitive prices while ensuring product consistency and regulatory compliance. They should understand the market dynamics and establish relationships with reliable isobutavan suppliers.
Sourcing Strategies for Bulk Vanillin Isobutyrate Buyers
When sourcing vanillin isobutyrate in wholesale quantities, isobutavan buyers should prioritize:
- Manufacturers with dedicated production facilities and stringent quality control processes.
- Suppliers holding relevant industry certifications.
- Companies with transparent supply chains and documented compliance with regulatory standards.
As a bulk manufacturer and supplier of isobutavan in China, we supply high-quality vanillin isobutyrate for food, flavour, fragrance, and pharmaceutical industries. We also wholesale isobutavan to small customers. Normally, they want to buy vanillin isobutyrate in small quantities. To serve them, we can wholesale isobutavan at bulk prices and provide a one-stop purchasing service.
Vanillin Isobutyrate (Isobutavan) Prices (USD/Kg)
Food Grade Vanillin Isobutyrate (Isobutavan) Prices (GC Purity: >=99.0%)
| Volume | Unit Price | Shipment |
| 50g | 19 USD | Express |
| 500g | 95 USD | Express |
| 1Kg | 135 USD/Kg | Express |
| 20Kg | 20% cheaper | Express |
| 100Kg-Above | negotiable | Express / Sea |
Vanillin isobutyrate prices have experienced notable fluctuations in these two years, drawing attention from stakeholders across the food, flavor, and fragrance industries. As for the year 2025, isobutavan prices stabilized at approximately $120-140 per kilogram for food applications. In North America, food-grade material (98-100% purity, Kosher, FEMA certified) commands $183-206/kg at 10-25kg volumes. European vanillin isobutyrate price is approximately €140-155/kg at 5kg volumes. Chinese isobutavan manufacturers offer the most competitive pricing at $135/kg for kilogram orders and $85-100/kg for bulk quantities exceeding 100kg. Normally, bulk isobutavan orders trade at a 15-30% discount, depending on the order volumes.
Isobutavan pricing fluctuations are influenced by several factors:
- Petroleum derivatives market conditions (as precursor chemicals are petroleum-based).
- Seasonal demand variations in end-user industries.
- Transportation and logistics costs.
- Regulatory compliance requirements in different regions.
Furthermore, the above price quotations of vanillin isobutyrate isobutavan, especially for small orders, do not include the express shipping fee. The reason is that the shipment cost of vanillin isobutyrate may exceed the value of the sample. However, the bulk isobutavan wholesale prices will be much lower than those of small orders. Please contact us for more details.
Vanillin Isobutyrate (Isobutavan) Uses
Food and Beverage Uses
In the food industry, vanillin isobutyrate serves as a premium flavoring agent. Unlike traditional vanillin, it provides a richer, more complex vanilla profile with subtle buttery notes and enhanced stability. This makes it particularly valuable in:
- Premium chocolate products where its higher heat stability prevents flavor degradation during processing.
- Ice cream and frozen desserts where it maintains flavor integrity during freeze-thaw cycles.
- Baked goods that require long-lasting vanilla notes that withstand high temperatures.
- Beverages, especially those requiring extended shelf life or heat processing.
The compound’s low usage rates (typically 1-5 ppm) make it economically attractive despite its higher cost compared to standard vanillin.
Fragrance Uses
Perfumers value vanillin isobutyrate for its distinctive olfactory profile. It provides:
- A warm, sweet base note, creamy vanilla aroma with subtle woody undertones.
- Enhanced longevity compared to traditional vanillin.
- Better stability in alcohol-based formulations.
- Lower crystallization tendencies in concentrated solutions.
- Blends exceptionally well with other aromatic compounds.
These properties make it ideal for fine fragrances, luxury personal care products, and premium home scenting applications.
Pharmaceutical Uses
In pharmaceuticals, vanillin isobutyrate serves several practical purposes:
- Taste-masking for bitter active pharmaceutical ingredients (APIs).
- Stability enhancement for certain drug formulations.
- Flavor consistency across different manufacturing batches.
- Improved patient compliance for pediatric medications.
Technical Advantages
What sets vanillin isobutyrate apart from traditional vanillin compounds is its molecular structure, which offers:
- Higher lipid solubility for improved incorporation into oil-based systems.
- Reduced hygroscopicity, leading to better stability in humid environments.
- Slower release profile, providing sustained flavor/aroma delivery.
- Higher flash point and thermal stability.
Regulatory Status
Vanillin isobutyrate is generally recognized as safe (GRAS) by major regulatory bodies, including the FDA and EFSA. It’s approved for use in food applications with established maximum usage levels that vary by food category.
Vanillin Isobutyrate (Isobutavan) Benefits
Enhanced Flavor Stability
One of the most significant advantages of vanillin isobutyrate is its remarkable stability. Unlike natural vanilla extract or pure vanillin, it demonstrates superior resistance to:
- High temperatures during processing
- Exposure to light
- Acidic environments
- Prolonged storage conditions
This stability makes it particularly valuable in products that undergo extensive processing or have long shelf lives.
Cost-Effectiveness
The global vanilla market faces significant price volatility due to limited growing regions, labor-intensive cultivation practices, and vulnerability to weather events. Vanillin isobutyrate provides manufacturers with a reliable, cost-effective alternative that delivers consistent vanilla notes without dependency on volatile natural vanilla markets.
Flavor Enhancement Properties
Vanillin isobutyrate possesses exceptional flavor-enhancing capabilities. Even at low concentrations, it can intensify existing flavor profiles and create more complete, rounded taste experiences.
Lower Required Dosage
Compared to traditional vanillin, vanillin isobutyrate often requires significantly lower dosages to achieve a comparable flavor impact. This characteristic not only improves cost efficiency but can also reduce potential concerns about ingredient load in final products.
Extended Release Profile
The molecular structure of vanillin isobutyrate creates a more gradual release of flavor compared to pure vanillin. This property results in a more sustained flavor experience that develops over time, particularly beneficial in confectionery, chewing gum, and certain beverage applications.
Vanillin Isobutyrate (Isobutavan) Used in Flavour and Fragrance
A Flavour Enhancer for Preparing Fruit Flavour
Include the following ingredients (by weight): vanillin isobutyrate, 8 parts; ethyl vanillin 1, 2-propylene glycol acetal, 8 parts; vanillin 1, 2-propylene glycol acetal, 8 parts; 4-hydroxy-2, 5-dimethyl-3(2H) furanone, 3 parts; maltol propionate, 2 parts.
In conclusion, vanillin isobutyrate isobutavan represents an innovative solution in the food, pharmaceutical, flavor, and fragrance industries. It provides manufacturers with a reliable, technically superior alternative that enables consistent product quality regardless of vanilla market fluctuations. As a bulk manufacturer and supplier of vanillin isobutyrate in China, we sell different grades of Isobutavan at wholesale prices to large manufacturers and small customers worldwide.