This section focuses on an overview of vanillyl butyl ether as well as its manufacturing processes and uses. Also, please check out the introduction to vanillyl butyl ether manufacturers, supply chain issues, vanillyl butyl ether suppliers, and vanillyl butyl ether prices. Sinofi can help you buy high-quality vanillyl butyl ether in bulk for your industry applications at wholesale prices based on FEMA 3796 and CAS 82654-98-6.
Table of Contents
What is Vanillyl Butyl Ether?
Vanillyl butyl ether (VBE) is a synthetic organic compound that has gained significant attention in the food, cosmetic, and pharmaceutical industries due to its unique properties. It is known for its stability and effectiveness as a warming agent. Chemically, vanillyl butyl ether consists of a vanillyl group connected to a butyl chain through an ether linkage. This structural composition gives VBE both hydrophilic and lipophilic properties, making it versatile in various formulations. Vanillyl butyl ether functions primarily as a TRPV1 (transient receptor potential vanilloid 1) channel modulator. When applied topically, VBE activates these receptors, creating a warming sensation without the intense burning associated with capsaicin. This activation leads to increased local blood circulation and temporary desensitization of nerve endings, contributing to its warming and analgesic effects. It features a characteristic warm sensation when applied to skin without irritating, making it valuable in cosmetic and personal care applications. According to the U.S. Food and Drug Administration (FDA), vanillyl butyl ether is approved to be used in food, flavour and fragrance, pharmaceutical, and cosmetic industries. It has also been evaluated by relevant regulatory authorities like JECFA, EUR-Lex, ECHACHEM, NIST, and WHO. The IFRA Transparency List also provides a guideline to ensure the use of vanillyl butyl ether in the food, flavor, fragrance, pharmaceutical, and cosmetic industries.
VBE has several valuable properties:
- Mild cooling sensation upon skin contact
- Pleasant aromatic profile with vanilla notes
- Good solubility in organic solvents
- Stability at moderate temperatures
- Low irritation potential
CAS No.: 82654-98-6
According to the American Chemical Society, the CAS number of vanillyl butyl ether is 82654-98-6.
CAS Name: Vanillyl butyl ether
Molecular Formula: C12H18O3
Molecular Mass: 210.27
Appearance: Colorless to pale yellow, clear, viscous liquid
Solubility: Soluble in alcohols and oils, insoluble in water (236.4 mg/L @ 25 °C).
Other Names:
♦ Butyl vanillyl ether
♦ Hotact VBE
♦ Vanillyl alcohol butyl ether
♦ Sensehot
♦ Vanillyl alcohol n-butyl ether
Vanillyl Butyl Ether Odor
Faint vanilla fruity.
FEMA Number 3796
According to the Flavor and Extract Manufacturers Association (FEMA), the number of vanillyl butyl ether is FEMA 3796.
Bulk Vanillyl Butyl Ether Manufacturers
The global market for bulk vanillyl butyl ether is dominated by several specialized aromatic chemical companies. Top vanillyl butyl ether manufacturers like Givaudan are leading producers of flavors and fragrances that have invested significantly in VBE production capacity. Chinese manufacturers have expanded VBE production to meet growing demand in the pharmaceutical and cosmetic industries.
Sinofi is a bulk vanillyl butyl ether manufacturer in China, and we have a manufacturing facility with 2,500 square meters for the production of vanillyl butyl ether. We supply high-quality vanillyl butyl ether at bulk prices and serve food, flavour and fragrance, pharmaceutical, and cosmetic manufacturers worldwide.
Manufacturing Process of Vanillyl Butyl Ether
The manufacturing of vanillyl butyl ether represents a sophisticated blend of organic chemistry and industrial engineering.
Manufacturing Process
The industrial production of vanillyl butyl ether typically follows a multi-step process:
Raw Material Preparation
The primary starting materials include:
- Vanillyl alcohol
- n-Butanol
- Catalysts (anhydrous sodium sulfate)
- Solvents and reagents for purification
Williamson Ether Synthesis
The core reaction involves a modified Williamson ether synthesis:
- Vanillyl alcohol is then activated by catalysts.
- The activated intermediate reacts with butanol in the presence of a base to form the ether linkage.
Purification Process
Following synthesis, the crude product undergoes several purification steps:
- Solvent extraction is used to separate the product from reaction byproducts.
- Column chromatography or fractional distillation for further purification.
- Crystallization to obtain high-purity VBE.
- Final quality control testing for purity and impurity levels.
Bulk Vanillyl Butyl Ether Suppliers
The global supply of bulk vanillyl butyl ether is dominated by specialized chemical companies with capabilities in precise synthesis and stringent quality control. Top vanillyl butyl ether suppliers like Givaudan focus on high-purity VBE for food, pharmaceutical, and cosmetic applications.
Sinofi is a bulk vanillyl butyl ether supplier in China, and we have a warehouse with 1,200 square meters for high-quality vanillyl butyl ether. We sell different grades of vanillyl butyl ether at wholesale prices to food, flavour and fragrance, pharmaceutical, and cosmetic manufacturers.
Supply Chain of Vanillyl Butyl Ether
The vanillyl butyl ether supply chain represents a complex global network linking petrochemical industries, agricultural production, flavour and fragrance manufacturing.
Supply Chain Structure
The VBE supply chain follows a multi-tiered structure:
Raw Material Suppliers
- Vanillyl alcohol producers (both natural and synthetic)
- Butanol manufacturers
- Catalyst and processing aid suppliers
Vanillyl Butyl Ether Manufacturers
- Specialized VBE producers
- Chemical intermediaries
- Quality control and testing facilities
Distributors and Wholesalers
- Chemical distributors specializing in specialty ingredients
- Regional wholesalers
- Trading companies facilitating international commerce
Formulators and Product Manufacturers
- Cosmetic companies
- Pharmaceutical manufacturers
- Food product developers
- Flavor and fragrance houses
Retail and End-User Distribution
- Retail channels
- Professional service providers (e.g., spas, clinics)
- Online direct-to-consumer channels
As consumer preferences shift toward transparent, sustainable, and naturally derived ingredients, this supply chain continues to evolve through technological innovation and structural reorganization to meet these changing demands while maintaining cost-effectiveness and reliability.
Wholesale and Buy Vanillyl Butyl Ether in Bulk
For manufacturers regularly using vanillyl butyl ether in their formulations, wholesale purchasing represents a strategic approach to resource management. By understanding market dynamics, establishing relationships with reputable vanillyl butyl ether suppliers, and implementing proper storage protocols, companies can optimize their supply chain while ensuring consistent product quality.
Benefits of Buying Vanillyl Butyl Ether in Bulk
Cost Efficiency
Purchasing vanillyl butyl ether wholesale typically results in significant cost savings. Bulk orders generally come with reduced per-unit pricing, allowing manufacturers to optimize their material costs while maintaining product quality. Depending on quantity and supplier relationships, savings can range from 15-30% compared to smaller volume purchases.
Supply Chain Stability
Securing larger quantities ensures production continuity and reduces the risk of manufacturing delays. With a steady supply of this ingredient, businesses can maintain consistent formulation quality and meet production schedules reliably.
Quality Consistency
Reputable bulk suppliers typically provide consistent quality across batches, which is crucial for maintaining product standards. When sourcing from established chemical distributors, manufacturers can expect reliable purity levels and standardized specifications.
Finding Reliable Suppliers
When sourcing vanillyl butyl ether in bulk quantities, consider these factors:
- Certification and Compliance: Verify that suppliers meet relevant industry standards and regulatory requirements.
- Minimum Order Quantities: Understand the supplier’s MOQ policies to ensure they align with your production needs.
- Purity Specifications: Request detailed certificates of analysis to confirm product quality.
As a bulk vanillyl butyl ether manufacturer and supplier in China, we supply high-quality vanillyl butyl ether for food, flavour and fragrance, pharmaceutical, and cosmetic industries. We also wholesale vanillyl butyl ether to small customers. Normally, they want to buy vanillyl butyl ether in small quantities. To serve them, we can wholesale vanillyl butyl ether at bulk prices and provide a one-stop purchasing service.
Vanillyl Butyl Ether Prices (USD/Kg)
Food Grade Vanillyl Butyl Ether Prices (GC Purity: >=99%)
| Volume | Unit Price | Shipment |
| 50g | 25 USD | Express |
| 500g | 126 USD | Express |
| 1Kg | 180 USD/Kg | Express |
| 20Kg | 30% cheaper | Express |
| 100Kg-Above | negotiable | Express / Sea |
Vanillyl butyl ether prices have experienced notable price fluctuations over the past year. As of 2025, they have stabilized at approximately $150-200 per kilogram for food, flavour, fragrance, and cosmetic grades, following significant volatility throughout 2024.
Market Drivers
Several factors are currently influencing vanillyl butyl ether prices:
- Growing demand from premium cosmetics and skincare products.
- Increased consumer preference for “warming sensation” personal care items.
- Supply chain recovery following post-pandemic disruptions.
Furthermore, the above price quotations of vanillyl butyl ether, especially for small orders, do not include the express shipping fee. The reason is that the shipment cost of vanillyl butyl ether may exceed the value of the sample. However, the bulk wholesale prices of vanillyl butyl ether will be much lower than those of small orders. Please contact us for more details.
Vanillyl Butyl Ether Uses
Cosmetic and Personal Care Uses
In the cosmetics and personal care sector, vanillyl butyl ether is primarily valued for its warming properties. When applied to the skin, it creates a mild, pleasant warming sensation without irritation. This makes it an excellent ingredient in:
- Anti-cellulite creams and body contouring products.
- Massage oils and balms for muscle relaxation.
- Sports warming creams that help prepare muscles before exercise.
- Lip plumping products that create a gentle tingling effect.
Unlike other warming agents like capsaicin, VBE provides a milder sensation that many consumers find more comfortable and pleasant.
Fragrance Uses
Despite not having a strong vanilla scent itself, vanillyl butyl ether is used in the fragrance industry as a fixative and enhancer. It helps to:
- Stabilize more volatile aromatic compounds.
- Add subtle warmth and depth to fragrance compositions.
- Extend the longevity of scents in perfumes and colognes.
Pharmaceutical Uses
In pharmaceuticals, vanillyl butyl ether has found use in:
- Topical analgesic preparations for minor pain relief.
- Products targeting peripheral circulation improvement.
- Respiratory formulations where gentle warming sensations can help with congestion relief.
Food Uses
While less common than in other industries, VBE has limited applications in food products:
- As a flavor enhancer in certain specialty food items.
- In some countries, as a warming agent in spicy candy and gum products.
Vanillyl Butyl Ether Benefits
Skin Benefits
Vanillyl butyl ether offers several advantages for skincare formulations:
- Warming sensation: VBE creates a gentle warming effect when applied to the skin, making it valuable in massage oils and pain relief products.
- Micro-circulation enhancement: The compound stimulates blood flow to the skin’s surface, potentially improving nutrient delivery and cellular oxygenation.
- Anti-inflammatory properties: Research suggests VBE may help reduce skin inflammation, benefiting those with sensitive or irritated skin conditions.
Anti-Aging Benefits
The compound has gained attention for its potential anti-aging benefits:
- Antioxidant activity: Similar to its parent compound vanillin, VBE exhibits antioxidant properties that help neutralize free radicals and reduce oxidative stress.
- Cellular protection: By scavenging free radicals, VBE may help protect skin cells against environmental damage from UV radiation and pollution.
Benefits in Cosmetics
The cosmetic industry has embraced vanillyl butyl ether for several reasons:
- Enhanced product stability: VBE remains stable in various formulations and pH levels, extending the shelf life of products.
- Pleasant sensory profile: It imparts a mild, pleasant warming sensation without the burning or irritation associated with other warming agents.
- Compatibility: VBE works well with numerous other cosmetic ingredients, making it versatile for formulators.
Weight Management Support
Some studies suggest potential benefits for weight management applications:
- Thermogenic effects: The warming properties of VBE may temporarily increase metabolic rate when used in topical slimming products.
- Lipolysis support: Research indicates it might enhance the breakdown of fat cells when used in specialized formulations.
Vanillyl Butyl Ether Used in Cosmetics
A Heating Composition for Skin Care Products
Include the following ingredients:
Ginger root extract, Vanillyl butyl ether, Angelica extract, Oat alkaloids, Ginseng extract, Sage extract.
- Ginger root extract: water extract, 10:1 ginger root ratio extract.
- Vanillyl butyl ether: purity 99%.
- Angelica extract: water extract, 10:1 angelica ratio extract.
- Oat alkaloids: purity 99%.
- Ginseng extract: water extract, 10:1 ginseng ratio extract.
- Sage extract: water extract, 10:1 sage ratio extract.
The preparation method is as follows:
Step 1: Prepare a composite extract, specifically comprising:
- Put 2.8kg ginger root extract, 0.08kg angelica extract, 0.18kg ginseng extract, 0.18kg sage extract, and 21kg water into a stirring kettle, rotate at 60r/min, stir until dissolved, and obtain a composite extract.
- 0.14kg of aluminum oxide and 0.07kg of titanium oxide were added to the composite extract, the stirred kettle was sealed and pressurized to 1MPa, heated to 120℃, kept constant temperature for 1h, cooled naturally to room temperature, depressurized, and aluminum oxide and titanium oxide were filtered out through a filter to obtain a treated extract.
- The treated extract was concentrated by rotary evaporation at a rotary evaporation pressure of 0.01MPa and a rotary evaporation temperature of 60℃ to a paste, and the paste was sprayed with powder and dried to obtain a composite extract.
Step 2: Preparing a heat-generating composition for skin care products:
95.9kg of vanillyl butyl ether, 0.58kg of oat alkaloids, and 3.24kg of the composite extract were added to a stirred kettle, the speed was 60 rpm/min, stirred for 10 minutes, and mixed evenly to obtain the final heat-generating composition for skin care products.
In conclusion, vanillyl butyl ether represents an innovative ingredient with multiple benefits across skincare, anti-aging, and specialized cosmetic applications. Its unique warming properties, combined with antioxidant potential and good stability, make it a valuable component in modern formulations. As a bulk manufacturer and supplier of vanillyl butyl ether in China, we sell different grades of vanillyl butyl ether at wholesale prices to large manufacturers and small customers worldwide.