This section provides an overview of 2,3-diethyl-5-methylpyrazine (hazelnut pyrazine), covering its manufacturing processes, applications, and regulatory status. Also, please check out the introduction to 2,3-diethyl-5-methylpyrazine manufacturers, supply chain issues, 2,3-diethyl-5-methylpyrazine suppliers, and 2,3-diethyl-5-methylpyrazine prices. Sinofi can help you buy high-quality 2,3-diethyl-5-methylpyrazine in bulk for industry applications at wholesale prices based on FEMA 3336 and CAS 18138-04-0.
Table of Contents
What is 2,3-Diethyl-5-Methylpyrazine (Hazelnut Pyrazine)?
2,3-Diethyl-5-methylpyrazine, commonly referred to as hazelnut pyrazine, represents one of the most significant aromatic compounds in the flavour industry’s repertoire for creating authentic nut-based flavour profiles. It belongs to the pyrazine family, a class of molecules renowned for their distinctive roasted, nutty, and earthy sensory characteristics that play crucial roles in both natural and artificial flavour systems. 2,3-Diethyl-5-methylpyrazine consists of a six-membered aromatic ring, with ethyl groups attached at positions 2 and 3, and a methyl group at position 5. This specific substitution pattern creates unique steric and electronic properties that directly influence its sensory characteristics and behavior in flavour matrices. According to the U.S. Food and Drug Administration (FDA), 2,3-diethyl-5-methylpyrazine is approved to be used in the food, flavour, and fragrance industries.
Regulatory Considerations and Safety
Regulatory bodies, including JECFA, EFSA, RIFM, ECHACHEM, NIST, and WHO, have affirmed the safety profile of 2,3-diethyl-5-methylpyrazine in food, flavour, and fragrance applications. The compound appears on the positive lists of flavouring substances in major markets, including the United States and the European Union. However, formulation engineers must remain cognizant of maximum usage levels specified in various regional regulations and industry guidelines, particularly the recommendations provided by the JECFA and FEMA. The fragrance standard of hazelnut pyrazine has been set by organizations such as IFRA.
Natural Occurrence
In nature, 2,3-diethyl-5-methylpyrazine forms primarily through the Maillard reaction during thermal processing. The specific precursors and reaction conditions influence the yield and ratio of various pyrazine derivatives formed. The compound has been identified in numerous food products subjected to roasting or high-temperature processing. Notable natural sources include roasted coffee beans, cocoa products, roasted peanuts, and various toasted grains. Its presence in fermented products such as soy sauce and certain aged cheeses has also been documented, though typically at lower concentrations than in roasted materials.
Sensory Characteristics and Odor Profile
The sensory profile of 2,3-diethyl-5-methylpyrazine is characterized by its powerful roasted, nutty, and hazelnut notes. At lower concentrations, the compound exhibits a pronounced hazelnut-like character with subtle cocoa undertones, while at higher concentrations, it develops more intense roasted and coffee-like attributes. The compound contributes significantly to the characteristic aroma of roasted foods, particularly in applications where Maillard reaction products are desired. Its sensory impact extends beyond simple nutty notes, providing depth and complexity that enhances the overall flavour experience. The earthy, slightly vegetable-like facets that emerge at certain concentrations make it particularly valuable in savory applications where umami and kokumi effects are sought.
CAS No.: 18138-04-0
According to the American Chemical Society, the CAS number of 2,3-diethyl-5-methylpyrazine is 18138-04-0.
CAS Name: 2,3-Diethyl-5-methylpyrazine
Molecular Formula: C9H14N2
Molecular Mass: 150.22
Appearance: Colorless to light yellow, clear liquid
JECFA Number: 777
Boiling Point: 191.00 to 193.00 °C. @ 760.00 mm Hg
Solubility: Soluble in alcohol and organic solvents. Soluble in water (1636 mg/L @ 25 °C).
Other Names:
♦ Hazelnut Pyrazine
♦ Pyrazine, 2,3-diethyl-5-methyl-
♦ 2-Methyl-5,6-diethylpyrazine
♦ 5-Methyl-2,3-diethylpyrazine
♦ 2,3-Diethyl-6-methylpyrazine
2,3-Diethyl-5-Methylpyrazine Odor
Odor Strength: High, recommend smelling in a 0.10 % solution or less.
Substantivity: 4 hour(s) at 100.00%
Odor Description: At 0.10% in dipropylene glycol, roasted hazelnut; nutty; meaty.
FEMA Number 3336
According to the Flavour and Extract Manufacturers Association (FEMA), the 2,3-diethyl-5-methylpyrazine FEMA number is 3336.
Bulk 2,3-Diethyl-5-Methylpyrazine Manufacturers
The bulk manufacturing of 2,3-diethyl-5-methylpyrazine includes both specialized chemical suppliers and fragrance companies. Top 2,3-diethyl-5-methylpyrazine manufacturers like Lluch Essence, Mane, and Sigma-Aldrich possess the technical expertise and regulatory compliance capabilities necessary for hazelnut pyrazine. Chinese manufacturers specializing in pyrazine derivatives with competitive factory-direct pricing.
Sinofi is a bulk 2,3-diethyl-5-methylpyrazine manufacturer in China, and we have a manufacturing facility with 2,500 square meters for the production of hazelnut pyrazine. We supply high-quality 2,3-diethyl-5-methylpyrazine at bulk prices and serve global clients in the food, flavour, and fragrance sectors.
Manufacturing Process of 2,3-Diethyl-5-Methylpyrazine
The manufacturing of 2,3-diethyl-5-methylpyrazine represents a well-established industrial process that combines traditional organic synthesis principles with modern process optimization techniques. The most economically viable industrial approach involves the condensation of appropriate dicarbonyl compounds with diamines or their equivalents. The preferred route utilizes 2,3-diethyl-1,4-diketone and methylamine derivatives under controlled thermal conditions. This method provides good yields while maintaining cost-effectiveness for large-scale production.
Bulk 2,3-Diethyl-5-Methylpyrazine Suppliers
The bulk supply of 2,3-diethyl-5-methylpyrazine demonstrates robust fundamentals supported by diverse end-use applications and growing global demand. Top 2,3-diethyl-5-methylpyrazine suppliers like Lluch Essence, Mane, and Sigma-Aldrich offer technical expertise, regulatory compliance, and reliable supply chains. Chinese suppliers dominate the global supply due to their integrated supply chains and competitive manufacturing costs.
Sinofi is a bulk 2,3-diethyl-5-methylpyrazine supplier in China, and we have a warehouse with 1,200 square meters for high-quality hazelnut pyrazine. We sell different grades of 2,3-diethyl-5-methylpyrazine at wholesale prices to food, flavour, and fragrance manufacturers.
Supply Chain of 2,3-Diethyl-5-Methylpyrazine
The 2,3-diethyl-5-methylpyrazine supply chain represents a sophisticated network supporting critical applications across the food, beverage, and fragrance industries.
Supply Chain Structure Overview
The supply chain of 2,3-diethyl-5-methylpyrazine operates through a multi-tiered structure encompassing raw material suppliers, specialized manufacturers, distributors, and end-users across diverse industries.
Upstream Raw Materials and Precursors
The production of 2,3-diethyl-5-methylpyrazine relies on the raw material supply base, consisting of petrochemical derivatives and specialized chemical intermediates.
Manufacturing and Production Tier
The manufacturing segment represents the most critical component of the supply chain, where raw materials undergo complex chemical transformations to produce the final compound. China has emerged as a significant manufacturing hub for pyrazine derivatives.
Distribution and Logistics Tier
The distribution tier encompasses specialized chemical distributors, flavour and fragrance intermediaries, and direct sales channels. The logistics requirements for 2,3-diethyl-5-methylpyrazine reflect its specialty chemical status, requiring temperature-controlled storage, proper hazard classification handling, and documentation supporting food-grade or cosmetic-grade applications.
End-User Applications
The end-user tier demonstrates remarkable diversity, spanning multiple industries with distinct requirements and procurement patterns. Primary application sectors include food and beverage manufacturing, flavour compounding, fragrance formulation, and specialized industrial applications.
Wholesale and Buy 2,3-Diethyl-5-Methylpyrazine in Bulk
Wholesale buy of 2,3-diethyl-5-methylpyrazine in bulk requires a comprehensive understanding of supplier capabilities and organizational requirements. Through careful supplier evaluation and effective relationship management, hazelnut pyrazine buyers can optimize both cost and supply security outcomes.
Supplier Evaluation Framework
Successful bulk procurement requires a comprehensive supplier assessment encompassing multiple evaluation criteria. Quality certifications, including ISO standards and industry-specific accreditations, provide fundamental indicators of supplier capability and reliability. Regulatory compliance constitutes an essential evaluation component.
Procurement Strategy Development
Effective bulk purchasing strategies for 2,3-diethyl-5-methylpyrazine require a careful balance between cost optimization and supply security. Long-term contracts can provide price stability and guaranteed supply availability, particularly valuable given the specialized nature of the compound and limited supplier base. Volume consolidation opportunities should be evaluated in coordination with production planning teams to maximize purchasing power while maintaining appropriate inventory levels.
As a bulk manufacturer and supplier of 2,3-diethyl-5-methylpyrazine in China, we supply high-quality hazelnut pyrazine for food, flavour, and fragrance industries. We also wholesale hazelnut pyrazine to small customers. Normally, they want to buy 2,3-diethyl-5-methylpyrazine in small quantities. To serve them, we can wholesale 2,3-diethyl-5-methylpyrazine at bulk prices and provide a one-stop purchasing service.
2,3-Diethyl-5-Methylpyrazine Prices (USD/Kg)
Food Grade 2,3-Diethyl-5-Methylpyrazine Prices (GC Content >=99.0%)
| Volume | Unit Price | Shipment |
| 50g | 105 USD | Express |
| 500g | 525 USD | Express |
| 1Kg | 750 USD/Kg | Express |
| 20Kg | >20% cheaper | Express |
| 100Kg-Above | negotiable | Express / Sea |
The 2,3-diethyl-5-methylpyrazine prices have experienced notable fluctuations in recent years, driven by evolving demand patterns in the food and beverage industry, supply chain dynamics, and regulatory considerations. Market prices vary significantly based on purchase volume, purity specifications, and geographic region. The pricing structure demonstrates clear economies of scale, with kilogram quantities priced at premium levels. Long-term supply agreements generally offer price stability advantages compared to spot market purchases.
Furthermore, the above price quotations of 2,3-diethyl-5-methylpyrazine do not include the express shipping fee. The reason is that the shipment cost of hazelnut pyrazine may exceed the value of the sample. However, the bulk wholesale prices of 2,3-diethyl-5-methylpyrazine will be much lower than those of small orders. Please contact us for more details.
2,3-Diethyl-5-Methylpyrazine Specification
| Appearance: | Colorless to light yellow, clear liquid |
| Odor: | Coffee, roasted hazelnut, nutty. |
| Purity (GC) | >=99% |
| Refractive Index (20°C) | 1.493 – 1.505 |
2,3-Diethyl-5-Methylpyrazine Uses
2,3-Diethyl-5-methylpyrazine represents a valuable compound with established applications across multiple industries, particularly in flavour and fragrance development.
Applications in the Flavour and Fragrance Industry
The most prominent application of 2,3-diethyl-5-methylpyrazine lies within the flavour and fragrance sector. This compound exhibits powerful organoleptic properties, contributing earthy, nutty, and roasted notes to various formulations. Food manufacturers extensively utilize this pyrazine derivative to enhance and replicate natural flavours in processed foods, particularly in products requiring coffee, chocolate, or roasted grain profiles.
In beverage manufacturing, this compound serves as a crucial component in creating authentic taste experiences. Coffee substitute products and instant coffee formulations frequently incorporate 2,3-diethyl-5-methylpyrazine to achieve the complex aromatic profile associated with freshly roasted coffee beans. Similarly, the compound finds application in alcoholic beverages, where it contributes to the development of aged and matured flavour notes.
The fragrance industry employs this pyrazine derivative to create sophisticated scent compositions. Perfumers value its ability to provide depth and complexity to fragrances, particularly in masculine and oriental perfume categories. The compound’s low odor threshold means that minimal quantities can produce a significant olfactory impact, making it economically attractive for commercial applications.
Applications in Food Processing and Preservation
Beyond its flavouring capabilities, 2,3-diethyl-5-methylpyrazine plays a functional role in food processing. The compound forms naturally during Maillard reactions, the chemical processes that occur when proteins and sugars are exposed to heat during cooking, baking, or roasting. Understanding this formation mechanism has enabled food technologists to optimize processing conditions to enhance desirable flavour development while maintaining product safety and nutritional value.
Research has indicated that certain pyrazine compounds, including 2,3-diethyl-5-methylpyrazine, may possess antimicrobial properties. While not primarily used as a preservative, its presence in food systems may contribute to extended shelf life and improved product stability. This dual functionality makes it particularly valuable in the development of natural preservation systems for processed foods.
Applications in Industrial Synthesis and Chemical Applications
The chemical industry utilizes 2,3-diethyl-5-methylpyrazine as an intermediate in various synthetic pathways. Its structural characteristics make it suitable for producing more complex organic molecules used in pharmaceutical research and development. The compound’s reactivity profile allows for selective functionalization, enabling chemists to create diverse molecular architectures for drug discovery programs.
In materials science, researchers have explored the potential of pyrazine derivatives in developing novel polymers and advanced materials. The nitrogen-containing heterocyclic structure provides opportunities for coordination with metal centers, potentially leading to applications in catalysis and materials with unique electronic properties.
2,3-Diethyl-5-Methylpyrazine Benefits
Environmental and Biotechnological Benefits
The compound’s very low odor threshold makes it significant in environmental monitoring and control applications, particularly in food processing facilities where odor management is important. This characteristic highlights the compound’s potency and the need for careful handling and monitoring in industrial applications.
2,3-Diethyl-5-Methylpyrazine Used in Flavour and Fragrance
2,3-Diethyl-5-methylpyrazine stands as an essential component in the modern flavour formulator’s toolkit, offering unique sensory properties that enhance a wide range of food and beverage applications. Its potent, roasted, nutty character, combined with excellent stability and regulatory acceptance, ensures its continued relevance in flavour creation.
The versatility of 2,3-diethyl-5-methylpyrazine in flavour formulation stems from its ability to enhance and round out flavour profiles across multiple application categories. In chocolate and cocoa flavours, it serves as a crucial component for recreating the complex notes associated with different roasting profiles. Typical usage levels in chocolate applications range from 0.5 to 5 parts per million in the finished product, depending on the desired intensity and specific flavour direction.
In coffee flavour systems, the compound works synergistically with other pyrazines and furans to create authentic roasted coffee profiles. Its contribution is particularly valuable in instant coffee applications where process-induced flavour losses need compensation. The compound helps restore the full-bodied character and aromatic complexity expected in premium coffee products. Savory applications represent another significant area where 2,3-diethyl-5-methylpyrazine demonstrates its value. In meat flavours, particularly those mimicking grilled or roasted preparations, it contributes to the characteristic browning notes that consumers associate with well-cooked protein products. The compound finds extensive use in seasoning blends, soup bases, and reaction flavours where it enhances the overall savory impact and provides authentic cooked notes.
Formulation Considerations and Stability
When incorporating 2,3-diethyl-5-methylpyrazine into flavour formulations, several technical considerations merit attention. The compound exhibits good stability under acidic conditions but may undergo degradation in strongly alkaline environments. Its volatility, while contributing to its impact in flavour applications, requires careful consideration during processing and storage to prevent losses.
The compound demonstrates excellent solubility in propylene glycol, triacetin, and other common flavour solvents, facilitating its incorporation into both oil-soluble and water-soluble flavour systems. In emulsion-based applications, proper encapsulation techniques can help optimize flavour release and extend shelf life. Interactions with other flavour components, particularly aldehydes and ketones, should be evaluated during formulation development to ensure stability and prevent undesired reaction products.
A Flavour Base Highlights the Roasted Aroma for Cigarettes
Include the following ingredients (by weight, %):
Water, 13.47; Ethanol, 70; 2-Ethyl-3,5-dimethylpyrazine, 0.8; 2,3-Diethylpyrazine, 1.5; 2,3-Diethyl-5-methylpyrazine, 0.2; 5-Methyl-6,7-dihydro-5H-cyclopentylpyrazine, 5; 2-Acetylpyrazine, 0.03; 3,4-Dimethyl-1,2-cyclopentanedione, 3; Ethylcyclopentenolone, 2.7; Ethyl maltol, 1.1; Furaneol, 2.2.
In conclusion, 2,3-diethyl-5-methylpyrazine demonstrates significant value across multiple industrial applications, primarily due to its distinctive aromatic properties and established safety profile. As a bulk 2,3-diethyl-5-methylpyrazine manufacturer and supplier in China, we sell different grades of hazelnut pyrazine at wholesale prices to large manufacturers and small customers worldwide.