This section provides an overview of 2-acetylthiazole, covering its manufacturing processes and regulatory status, applications in e-liquids, food, flavour, and fragrance industries. Also, please check out the introduction to 2-acetylthiazole manufacturers, supply chain issues, 2-acetylthiazole suppliers, and 2-acetylthiazole prices. Sinofi can help you buy 2-acetylthiazole at bulk wholesale prices based on FEMA 3328 and CAS 24295-03-2.
Table of Contents
What is 2-Acetylthiazole?
2-Acetylthiazole represents one of the most significant heterocyclic compounds in the flavour and fragrance industries. It has earned its position as an essential building block in savory flavour systems, particularly those designed to replicate roasted, cooked, and meaty characteristics. 2-Acetylthiazole is characterized by a five-membered aromatic ring containing both sulfur and nitrogen atoms, with an acetyl group attached at the 2-position. According to the U.S. Food and Drug Administration (FDA), 2-acetylthiazole is approved to be used in the e-liquids, food, flavour, and fragrance industries.
Regulatory Status and Safety Considerations
2-Acetylthiazole has been evaluated by relevant regulatory authorities like JECFA, EFSA, RIFM, ECHACHEM, NIST, and WHO. In the United States, it is recognized by the Flavor and Extract Manufacturers Association (FEMA) with GRAS status (Generally Recognized as Safe) under appropriate conditions of use. European regulations also permit its use as a flavouring substance, subject to applicable maximum levels and restrictions.
Sensory Profile and Organoleptic Properties
The aroma profile of 2-acetylthiazole is distinctly characterized by roasted, nutty, and popcorn-like notes. At higher concentrations, the compound delivers pronounced meaty and savory characteristics that are essential for creating authentic cooked meat flavours. The sensory experience includes subtle sulfurous undertones that contribute to overall complexity without becoming offensive when used at appropriate levels. The odor threshold of 2-acetylthiazole is remarkably low, typically measured in parts per billion, which means that even minute quantities can significantly impact the overall flavour profile.
Natural Occurrence
2-Acetylthiazole appears naturally in various cooked and roasted foods, including roasted meat, coffee, cocoa, and heated cereal products. This natural occurrence supports its acceptance as a nature-identical flavouring ingredient. However, formulation engineers must remain current with regional regulatory requirements, as specifications and permitted use levels may vary across different markets.
CAS No.: 24295-03-2
According to the American Chemical Society, the CAS number of 2-acetylthiazole is 24295-03-2.
CAS Name: 2-Acetylthiazole
Molecular Formula: C5H5NOS
Molecular Mass: 127.17
Appearance: Colorless to yellow, clear oily liquid.
JECFA Number: 1041
Boiling Point: 212.00 to 215.00 °C. @ 760.00 mm Hg
Solubility: Insoluble in water; Soluble in fats, oils, most organic solvents
Other Names:
♦ 2-Acetyl thiazole
♦ Methyl 2-thiazolyl ketone
♦ 1-(Thiazol-2-yl)ethan-1-one
♦ Ketone, methyl 2-thiazolyl
♦ 2-Thiazolyl methyl ketone
♦ 1-Thiazol-2-yl-ethanone
2-Acetylthiazole Odor
Odor Description: At 0.1% in dipropylene glycol, cocoa, hazelnut, popcorn, bread-like odour.
FEMA Number 3328
According to the Flavour and Extract Manufacturers Association (FEMA), the FEMA number of 2-acetylthiazole is 3328. The fragrance standard of 2-acetyl thiazole has been set by organizations such as IFRA.
Bulk 2-Acetylthiazole Manufacturers
The bulk production of 2-acetylthiazole is dominated by specialized fine chemical manufacturers and dedicated flavour ingredient suppliers. Top 2-acetylthiazole manufacturers like International Flavors & Fragrances and Ventos operate production facilities with capabilities ranging from several metric tons to hundreds of metric tons annually, depending on overall market demand and their position within the supply chain. Their product portfolios typically encompass hundreds of aroma chemicals, allowing customers to consolidate their supplier base and streamline procurement operations. China has emerged as a significant production center for 2-acetylthiazole and related flavour chemicals, with multiple manufacturers located in chemical production hubs. European 2-acetylthiazole manufacturers maintain an important presence in the market, particularly companies based in Switzerland, Germany, and the United Kingdom.
Sinofi is a bulk 2-acetylthiazole manufacturer in China, and we have a manufacturing facility with 2,500 square meters for the production of 2-acetyl thiazole and downstream application development for e-liquids, food, flavour, and fragrance industries. We supply high-quality 2-acetylthiazole at bulk prices and serve clients around the world.
Manufacturing Process of 2-Acetylthiazole
The commercial production of 2-acetylthiazole requires careful consideration of synthetic methodology, process efficiency, and product quality specifications. As a thiazole derivative with significant commercial value in the flavour and fragrance industry, the manufacturing process must balance chemical yield, purity requirements, and economic viability.
Primary Synthetic Route: Direct Acetylation of Thiazole
The most widely employed industrial method for producing 2-acetylthiazole involves the direct acetylation of thiazole using acetylating agents under controlled conditions. This approach offers advantages in terms of raw material availability, process simplicity, and overall economics. The reaction typically employs acetic anhydride or acetyl chloride as the acetylating agent in conjunction with a suitable Lewis acid catalyst, most commonly aluminum chloride or boron trifluoride etherate.
Alternative Synthetic Approaches
Several alternative synthetic routes to 2-acetylthiazole exist, though most find limited application in large-scale production due to economic or technical constraints. One approach involves the construction of the thiazole ring from appropriate precursors already bearing the acetyl functionality. This method typically employs alpha-haloacetone compounds reacting with thioamides under basic conditions through a cyclization mechanism. While this route offers certain advantages in terms of regioselectivity, the higher cost and limited availability of specialized starting materials generally render it less attractive for bulk production. Another methodology involves the oxidation of 2-ethylthiazole to introduce the carbonyl functionality.
Bulk 2-Acetylthiazole Suppliers
The global 2-acetylthiazole supply encompasses a diverse array of organizations ranging from 2-acetylthiazole manufacturers to specialized distributors and regional trading houses. Top 2-acetylthiazole suppliers like International Flavours & Fragrances and Ventos generally emphasize premium quality positioning, comprehensive regulatory support, and extensive technical service capabilities.
Sinofi is a bulk 2-acetylthiazole supplier in China, and we have a warehouse with 1,200 square meters for high-quality 2-acetyl thiazole. We sell different grades of 2-acetylthiazole at wholesale prices, serving e-liquid producers, flavour houses, food manufacturers, and fragrance companies worldwide.
Supply Chain of 2-Acetylthiazole
The supply chain for 2-acetylthiazole represents a specialized network connecting raw material suppliers, chemical manufacturers, distributors, flavour houses, and ultimately food and beverage companies.
Supply Chain Structure and Participant Tiers
The 2-acetylthiazole supply chain comprises five distinct tiers, each performing specific functions that collectively enable material flow from basic petrochemicals to finished consumer products. The structure reflects both the technical complexity of producing specialty aroma chemicals and the regulatory requirements governing their use in food applications.
At the foundation of the supply chain lie raw material suppliers providing the basic chemical building blocks necessary for 2-acetylthiazole synthesis. These tier-one suppliers produce thiazole, the primary starting material, along with acetylating agents such as acetic anhydride or acetyl chloride.
The manufacturing tier represents the second level of the supply chain, where 2-acetylthiazole producers convert raw materials into finished 2-acetylthiazole through synthesis, purification, and quality control processes.
The distribution and trading tier forms the third level, serving as intermediaries between manufacturers and end users. This tier includes authorized distributors maintaining inventory and providing logistical services, regional agents representing manufacturers in specific geographic markets, and trading companies.
Flavour houses constitute the fourth tier, representing the primary industrial customers for 2-acetylthiazole. These organizations formulate complex flavour systems incorporating dozens or hundreds of individual aroma chemicals to create specific taste and smell profiles for food and beverage applications.
The final tier comprises e-liquid, food, and beverage manufacturers who incorporate flavour systems into finished consumer products. While generally not purchasing 2-acetylthiazole directly, these organizations drive ultimate demand through product development activities and volume requirements.
Wholesale and Buy 2-Acetylthiazole in Bulk
The procurement of 2-acetylthiazole in wholesale quantities requires integration of technical knowledge, commercial acumen, and relationship management capabilities. 2-Acetylthiazole buyers must understand the material’s role in flavour applications, appreciate quality requirements and regulatory obligations, and develop supply chain strategies balancing cost optimization with supply reliability and risk management.
Defining Volume Requirements and Order Quantities
The foundation of effective bulk purchasing begins with an accurate assessment of consumption requirements across appropriate planning horizons. 2-Acetylthiazole buyers must analyze historical usage patterns, incorporate growth projections from business planning processes, and account for variability in production schedules to determine realistic volume forecasts.
Supplier Identification and Establishing Strategic Relationships
Identifying potential suppliers requires comprehensive market research encompassing manufacturers, authorized distributors, and trading companies serving target geographic markets. The qualification process must evaluate suppliers across multiple dimensions critical to successful long-term relationships. The transition from transactional purchasing relationships to strategic partnerships delivers benefits extending beyond immediate procurement outcomes. Strategic relationships characterized by mutual commitment, open communication, and collaborative problem-solving enable joint value creation through quality improvements, process optimization, and innovation.
Price Negotiation and Commercial Terms Structure
Wholesale pricing for 2-acetylthiazole varies substantially based on volume commitments, contract duration, delivery terms, and competitive dynamics among suppliers. Preparation for price negotiations requires market intelligence regarding prevailing pricing levels, an understanding of supplier cost structures, and clarity regarding organizational priorities between cost minimization and other factors such as quality assurance or supply reliability.
As a bulk 2-acetylthiazole manufacturer and supplier in China, we wholesale this aromatic ingredient to e-liquid producers, flavour houses, food manufacturers, and fragrance companies. We also supply it to small customers. Normally, they want to buy 2-acetylthiazole in small quantities. To serve them, we can sell 2-acetylthiazole at bulk prices and provide a one-stop purchasing service.
2-Acetylthiazole Prices (USD/Kg)
Food Grade 2-Acetylthiazole Prices (GC Content >=99.0%)
| Volume | Unit Price | Shipment |
| 50g | 52 USD | Express |
| 500g | 260 USD | Express |
| 1Kg | 370 USD/Kg | Express |
| 20Kg | >20% cheaper | Express |
| 100Kg-Above | negotiable | Express / Sea |
2-Acetylthiazole pricing reflects several interconnected factors, including raw material costs, production scale, competitive dynamics, and regional economic conditions. The primary raw materials for synthesis include thiazole or its precursors along with acetylating agents, and fluctuations in petrochemical feedstock prices can impact production economics. Energy costs, particularly in regions dependent on imported energy, also influence manufacturer pricing structures.
Furthermore, the above 2-acetylthiazole price quotations do not include the express shipping fee. The reason is that the shipment cost may exceed the value of the 2-acetyl thiazole sample. However, the bulk wholesale prices of 2-acetylthiazole will be much lower than those of small orders. Please contact us for more details.
2-Acetylthiazole Specification
| Appearance: | Colorless to light yellow, clear oily liquid. |
| Odor: | Cocoa, hazelnut, popcorn, bread-like odour. |
| Purity (GC) | >=99% |
| Specific Gravity | 1.219-1.228 |
| Refractive Index | 1.542-1.552 |
| Heavy Metal (as Pb, mg/Kg) | <=10.0 |
2-Acetylthiazole Uses
2-Acetyl thiazole serves as a versatile chemical compound with distinctive properties that make it valuable across multiple industrial applications.
Primary Application in Food Flavouring
The dominant use of 2-acetyl thiazole lies within the food and beverage industry, where it functions as a flavouring agent with distinctive sensory characteristics. The compound delivers a pronounced roasted, nutty aroma profile that closely resembles freshly roasted nuts, popcorn, and toasted grains. This specific flavour signature makes it particularly valuable in applications where manufacturers seek to create or enhance roasted flavour notes without relying solely on natural roasting processes.
In savory food applications, 2-acetyl thiazole contributes essential flavour complexity to snack seasonings, particularly those designed to replicate roasted or toasted characteristics. Potato chips, crackers, and extruded snacks frequently incorporate this compound within their seasoning systems to deliver authentic roasted flavour profiles. The compound works synergistically with other flavouring agents like ethyl maltol, 2-ethylpyrazine, and 2-acetylpyrrole, to create more complete and satisfying taste experiences that resonate with consumer expectations for savory snack products.
Meat flavouring systems represent another significant application area for 2-acetyl thiazole. The compound contributes to the characteristic roasted notes associated with grilled, roasted, or seared meat products. In processed meat applications, ready meals, and meat-flavoured seasonings, this chemical helps replicate the complex flavour development that occurs during traditional cooking processes. Its ability to enhance meaty, roasted characteristics makes it valuable in both traditional meat products and plant-based meat alternatives, where manufacturers strive to achieve authentic meat-like flavour profiles.
Beverage Industry Applications
Within the beverage sector, 2-acetyl thiazole finds application in coffee-flavoured products and certain specialty beverages. The compound’s roasted, nutty characteristics align naturally with coffee flavour profiles, allowing beverage formulators to enhance or modify coffee notes in ready-to-drink beverages, coffee-flavoured dairy products, and coffee-enhanced nutritional drinks. The compound helps maintain consistency in coffee flavour delivery across products where natural coffee components might vary due to sourcing or processing differences.
Baking and Confectionery Uses
The baking industry utilizes 2-acetyl thiazole in products where roasted or toasted flavour notes enhance overall taste profiles. Bread products, particularly those marketed with rustic or artisanal positioning, may incorporate this compound to emphasize crust-like, toasted characteristics. In confectionery applications, the compound contributes to nut-flavoured chocolates, praline-type products, and caramel formulations where roasted notes provide depth and complexity to sweetness.
Fragrance Industry Applications
Beyond food applications, 2-acetyl thiazole serves niche functions within the fragrance industry. The compound’s distinctive aroma characteristics find use in certain fragrance compositions where unconventional or gourmand notes create unique olfactory experiences. Perfumers may incorporate small quantities of this chemical to add unusual depth or complexity to fragrance formulations, particularly in products designed to evoke warmth or comfort through food-associated scent profiles.
2-Acetylthiazole in E-Liquid and Vaping Products
The presence of 2-acetylthiazole and other flavouring compounds in electronic cigarette liquids and vaping products represents a significant area of technical and regulatory concern within the nicotine delivery and tobacco harm reduction industries. The use of flavouring compounds in e-liquids serves multiple commercial purposes, including masking harsh characteristics of nicotine and propylene glycol, creating distinctive product identities that differentiate brands in competitive markets. The flavouring category encompasses hundreds of individual compounds ranging from simple esters and aldehydes to complex heterocyclic structures, including pyrazines, furans, and thiazoles such as 2-acetylthiazole. Within the e-liquid formulation context, 2-acetyl thiazole has been identified as a component of complex flavour systems, particularly those designed to deliver roasted, nutty, or tobacco-like characteristics. Its distinctive sensory profile makes it potentially useful for creating flavour profiles that appeal to adult smokers transitioning from combustible tobacco products, as roasted and nutty notes may evoke familiar taste experiences associated with traditional tobacco consumption.
2-Acetyl thiazole demonstrates reasonable solubility in propylene glycol and vegetable glycerin, allowing incorporation into e-liquid formulations at concentrations that deliver intended flavour characteristics. However, the high potency of 2-acetylthiazole necessitates precise measurement and thorough mixing to ensure uniform distribution throughout production batches and prevent concentration variations that might affect user experience or safety profiles. The concentration levels at which 2-acetyl thiazole appears in commercial e-liquids vary considerably depending on the specific flavour profile, manufacturer formulation practices, and regional regulatory requirements. Available analytical studies examining e-liquid composition have detected the compound at levels ranging from trace amounts to several parts per million in finished products, though comprehensive data on usage patterns across the industry remains limited due to proprietary formulation practices and variable analytical reporting.
The temperature ranges encountered during e-cigarette operation, typically between 200 and 300 degrees Celsius depending on device characteristics and user behavior, represent conditions under which chemical transformations may occur. While 2-acetyl thiazole demonstrates reasonable thermal stability, the possibility of decomposition or reaction with other e-liquid components under operating conditions requires investigation through appropriate analytical studies examining aerosol composition under realistic use conditions.
Regulatory Landscape and Compliance Considerations
The regulatory framework governing flavouring compounds in e-liquids varies substantially across jurisdictions, reflecting different policy approaches to vapor products and divergent views on appropriate regulation of these emerging product categories. In the United States, the Food and Drug Administration exercises regulatory authority over electronic nicotine delivery systems under the Family Smoking Prevention and Tobacco Control Act, which extends the agency’s tobacco product authority to include e-cigarettes and their components, including e-liquids.
2-Acetylthiazole Benefits
2-Acetylthiazole represents a valuable chemical compound that delivers substantial benefits across multiple dimensions of food manufacturing and flavour formulation.
Superior Flavour Delivery and Sensory Impact
The primary benefit of 2-acetyl thiazole lies in its exceptional ability to deliver authentic roasted and nutty flavour characteristics with remarkable efficiency. The compound provides a highly concentrated source of specific flavour notes that would otherwise require extensive processing or the use of multiple natural ingredients to achieve.
Formulation Flexibility and Technical Advantages
2-Acetyl thiazole provides substantial formulation flexibility that benefits product developers across diverse applications. The compound’s potency at very low usage concentrations means that formulators can achieve significant flavour impact without materially affecting other formulation parameters. This allows for flavour enhancement without compromising texture, appearance, or nutritional profiles, which proves particularly valuable in products with complex formulation requirements or stringent nutritional targets. The compound’s stability under typical food processing conditions represents another important technical benefit.
A Peanut Flavouring
Include the following ingredients (by weight):
1. Mix 6 parts of peanut meal and 60.02 parts of water, ultrasonicate for 0.5-1 hour, and remove solids by centrifugation to obtain a mixture A;
2. Mix 2,4-undecadienal 0.07 parts, 2-methyl-2-pentenal 0.08 parts, 2,6-dimethyl-5-heptenal 0.07 parts, 3-(2-furyl)acrolein 0.08 parts, 4-methyl-5-vinylthiazole 0.5 parts, and 2-acetylthiazole 0.1 parts, and then add peanut oil 56 parts and BHT 0.5 parts to obtain a mixture B;
3. Mix 15 parts of monoglycerol stearate and 0.03 parts of potassium sorbate, then add mixture B and mixture A, and stir evenly to obtain a peanut flavouring.
In conclusion, 2-acetylthiazole functions as a critical building block for creating authentic roasted and cooked notes. It proves particularly valuable in meat flavour systems. As a bulk 2-acetylthiazole manufacturer and supplier in China, we sell different grades of 2-acetylthiazole at wholesale prices to e-liquid producers, flavour houses, food manufacturers, and fragrance companies in the world.