This section focuses on an overview of 2,3-dimethylpyrazine as well as its manufacturing processes and uses. Also, please check out the introduction to 2,3-dimethylpyrazine manufacturers, supply chain issues, 2,3-dimethylpyrazine suppliers, and 2,3-dimethylpyrazine prices. Sinofi can help you buy high-quality dimethylpyrazine in bulk for industry applications at wholesale prices based on FEMA 3271 and CAS 5910-89-4.
Table of Contents
What is 2,3-Dimethylpyrazine?
2,3-Dimethylpyrazine is an important heterocyclic aromatic compound that has gained significant attention in various industrial applications, particularly in the food, fragrance, and chemical synthesis sectors. It stands as one of the most versatile and widely utilized pyrazine derivatives in modern flavor formulation. This heterocyclic aromatic compound plays a crucial role in creating complex flavor profiles that define many of our favorite foods and beverages. 2,3-Dimethylpyrazine belongs to the substituted pyrazine family, characterized by a six-membered aromatic ring containing two nitrogen atoms in the 1,4-positions, with methyl substituents at the 2 and 3 positions. This specific substitution pattern contributes significantly to its unique sensory characteristics and stability profile. According to the U.S. Food and Drug Administration (FDA), 2,3-dimethylpyrazine is approved to be used in the food, flavour, fragrance, and cosmetic industries.
Safety and Regulatory Considerations
2,3-Dimethylpyrazine represents a well-characterized flavouring compound with established safety profiles across international regulatory frameworks like EUR-Lex, ECHACHEM, EFSA, WHO, and JECFA. Current regulatory assessments demonstrate no safety concerns at established levels of intake, with the compound receiving Generally Recognized as Safe (GRAS) status from the FEMA and a favorable evaluation on Food Additives. The fragrance industry follows standards set by organizations such as IFRA.
Sensory Profile and Flavour Characteristics
The compound exhibits a powerful, multifaceted aroma profile dominated by nutty characteristics reminiscent of roasted peanut skins, complemented by rich coffee and unsweetened cocoa notes. Professional sensory evaluation reveals subtle meaty undertones that add complexity and depth to formulations. The flavor profile mirrors these aromatic qualities, delivering intense nutty and roasted sensations that can transform a bland base into a compelling consumer product.
Primary Notes
- Nutty, particularly reminiscent of roasted peanuts and hazelnuts
- Cocoa-like undertones with chocolate nuances
- Roasted grain character, similar to toasted bread or crackers
Secondary Notes
- Earthy, soil-like base notes
- Slightly green, vegetative aspects at higher concentrations
- Subtle coffee-like roasted characteristics
Threshold Values
- Odor threshold in water: approximately 1-10 ppb
- Taste threshold in water: approximately 10-50 ppb
- Optimal usage range: 0.1-10 ppm, depending on application
The compound demonstrates excellent stability under typical food processing conditions and maintains its characteristic profile across a wide pH range, making it particularly valuable for complex formulations.
Natural Occurrence
2,3-Dimethylpyrazine occurs naturally in thermally processed foods as a product of Maillard reactions between amino acids and reducing sugars. The compound has been identified as a component of roasted sesame seed aroma and contributes to flavor profiles in various heated food products. Consumption ratio analysis indicates that natural occurrence in foods results in exposure levels approximately 69 times greater than intake from intentional flavoring use in European populations, demonstrating substantial background dietary exposure.
CAS No.: 5910-89-4
According to the American Chemical Society, the CAS number of 2,3-dimethylpyrazine is 5910-89-4.
CAS Name: 2,3-dimethylpyrazine
Molecular Formula: C6H8N2
Molecular Mass: 108.14
Appearance: Colorless to light yellow, clear liquid
GRAS Number: 5, 25
JECFA Number: 755
Boiling Point: 155.00 to 157.00 °C. @ 760.00 mm Hg
Solubility: Completely miscible in ethanol; Excellent solubility in propylene glycol; Readily soluble in most carrier oils; Approximately 10,000 ppm in water at 25°C.
Other Names:
♦ Pyrazine, 2,3-dimethyl-
♦ 2,3-Dimethylpyrazine
♦ Pyrazine, 2,3-dimethyl-
♦ 2,3-Dimethyl-1,4-diazine
♦ 2,3-DMP pyrazine
♦ 2,3-Dimethyl-pyrazine
♦ Dimethylpyrazine
♦ Pyrazine, dimethyl-
2,3-Dimethylpyrazine Odor
Odor Strength: High, recommend smelling in a 0.10 % solution or less.
Substantivity: < 3 hour(s) at 100.00 %.
At 0.10 % in dipropylene glycol. nutty nut skin cocoa peanut butter coffee walnut caramellic roasted.
FEMA Number 3271
According to the Flavor and Extract Manufacturers Association (FEMA), the number of 2,3-dimethylpyrazine is FEMA 3271.
Bulk 2,3-Dimethylpyrazine Manufacturers
Key 2,3-dimethylpyrazine manufacturers include established chemical companies and specialized flavor ingredient suppliers, with significant production concentrated in North America, Europe, and the Asia-Pacific regions. Top 2,3-dimethylpyrazine manufacturers like Givaudan and Firmenich represent the premium segment of the market, focusing on high-purity products and specialized applications. The bulk production of 2,3-dimethylpyrazine is driven primarily by increasing demand for natural and enhanced flavor profiles in processed foods, expanding applications in the fragrance industry, and growing pharmaceutical manufacturing requirements.
Sinofi is a bulk 2,3-dimethylpyrazine manufacturer in China, and we have a manufacturing facility with 2,500 square meters for the production of dimethylpyrazine. We supply high-quality 2,3-dimethylpyrazine at bulk prices and serve food, flavour, fragrance, and cosmetic industries worldwide.
Manufacturing Process of 2,3-Dimethylpyrazine
Add ethylenediamine and 95% ethanol to a reaction kettle equipped with a stirrer, a reflux condenser and a thermometer, cool to 0°C with stirring, add dropwise a solution of diacetyl dissolved in 95% ethanol with stirring, heat and reflux for half an hour, cool slightly, add appropriate amounts of potassium hydroxide and metal oxide, and heat and reflux for 18 hours with stirring. After cooling and filtering off the catalyst, distill and recover the ethanol. Extract the residue with ether, dry the extract with anhydrous sodium sulfate, filter, and distill under reduced pressure, collect the fraction at 75°C to 78°C, and then refine by fractionation to obtain the product.
Bulk 2,3-Dimethylpyrazine Suppliers
The supplier ecosystem for bulk 2,3-dimethylpyrazine demonstrates a mixed structure of established chemical manufacturers and specialized flavor and fragrance companies. Top 2,3-dimethylpyrazine suppliers like Givaudan and Firmenich reveal strong market presence in North America, Europe, and Asia Pacific.
Sinofi is a bulk 2,3-dimethylpyrazine supplier in China, and we have a warehouse with 1,200 square meters for high-quality dimethylpyrazine. We sell different grades of 2,3-dimethylpyrazine at wholesale prices to food, flavour, fragrance, and cosmetic manufacturers.
Supply Chain of 2,3-Dimethylpyrazine
The 2,3-dimethylpyrazine supply chain represents a dynamic and evolving market ecosystem, characterized by steady growth prospects, technological advancement opportunities, and increasing applications across diverse industrial sectors. The primary demand driver stems from the food and beverage industry, where 2,3-dimethylpyrazine serves as a flavoring agent, particularly valued for roasted nuts and coffee products due to its characteristic nutty and earthy aroma.
Supply Chain Structure
Raw Materials Suppliers
The manufacturing of 2,3-dimethylpyrazine relies on several key raw materials that form the foundation of the supply chain.
Key Manufacturers and Suppliers
The manufacturing landscape is characterized by a mix of large chemical companies and specialized suppliers. Major global players held a significant share in terms of revenue, indicating moderate market concentration with opportunities for smaller specialized suppliers.
Distribution and Sales Channels
The distribution network operates through multiple channels to serve diverse end-user markets.
End-User Markets and Applications
Food and Beverage Sector
This segment represents the largest application area, driven by increasing consumer preferences for complex and authentic flavors, with particular growth in convenience foods and ready-to-eat meals.
Chemical Industry
Chemical reagent applications are experiencing growth due to expanding pharmaceutical research and development activities.
Research and Academic Institutions
Scientific research applications utilize 2,3-dimethylpyrazine as a model compound for investigating reaction mechanisms and properties of pyrazine derivatives.
Wholesale and Buy 2,3-Dimethylpyrazine in Bulk
Strategic wholesale procurement of 2,3-dimethylpyrazine requires a comprehensive approach that balances cost optimization with quality assurance and supply security objectives. Successful purchasing managers must develop a deep understanding of market dynamics, maintain strong supplier relationships, and implement robust quality management systems. Bulk purchasing offers substantial advantages for organizations with consistent consumption patterns. Volume discounts represent the most immediate benefit, with dimethylpyrazine suppliers typically offering tiered pricing structures that reward larger order quantities. These cost savings can significantly impact overall production economics, particularly for high-volume users. Supply chain stability constitutes another critical advantage of wholesale procurement. By securing larger quantities through long-term contracts, 2,3-dimethylpyrazine buyers can mitigate risks associated with supply disruptions, raw material shortages, or production delays at supplier facilities. This approach proves particularly valuable given the specialized nature of 2,3-dimethylpyrazine production and the limited number of qualified dimethylpyrazine suppliers in the global market. Inventory optimization becomes more achievable through strategic bulk purchasing. Dimethylpyrazine buyers can maintain adequate safety stock levels while reducing the frequency of procurement cycles, thereby decreasing administrative costs and minimizing the risk of stockouts that could disrupt production schedules.
2,3-Dimethylpyrazine Supplier Evaluation and Selection Criteria
Successful wholesale procurement of 2,3-dimethylpyrazine requires comprehensive supplier evaluation processes that extend beyond simple price comparisons. Manufacturing capability assessment forms the foundation of supplier selection, as the production of high-purity pyrazine compounds demands sophisticated chemical processing expertise and advanced quality control systems.
Regulatory compliance represents a non-negotiable requirement when evaluating potential suppliers. Vendors must demonstrate adherence to relevant food safety regulations, including FDA approval for food-grade applications and compliance with European Union food additive regulations.
Technical support capabilities deserve careful consideration during the supplier selection process. Preferred vendors should offer comprehensive technical documentation, including detailed product specifications, analytical certificates, and application guidance. The availability of regulatory support services, such as assistance with product registration and compliance documentation, adds significant value to the supplier relationship.
Geographic diversification of the supplier base helps mitigate risks associated with regional disruptions, regulatory changes, or transportation challenges. Maintaining relationships with suppliers across different continents provides flexibility in sourcing strategies and enhances supply security.
Quality Assurance and Specification Management
The procurement of 2,3-dimethylpyrazine requires rigorous quality assurance protocols to ensure consistent product performance across different supplier sources. Establishing comprehensive specification documents that define acceptable quality parameters, including purity levels, moisture content, and sensory characteristics, provides the foundation for effective quality management. Certificate of Analysis (CoA) review procedures ensure that each shipment meets established specifications before acceptance. Purchasing managers should establish clear protocols for CoA evaluation and define procedures for handling non-conforming materials, including supplier notification requirements and corrective action processes.
As a bulk 2,3-dimethylpyrazine manufacturer and supplier in China, we supply high-quality dimethylpyrazine for food, flavour, fragrance, and cosmetic industries. We also wholesale 2,3-dimethylpyrazine to small customers. Normally, they want to buy dimethylpyrazine in small quantities. To serve them, we can wholesale 2,3-dimethylpyrazine at bulk prices and provide a one-stop purchasing service.
2,3-Dimethylpyrazine Prices (USD/Kg)
Food Grade 2,3-Dimethylpyrazine Prices (FCC, GC Content >=99.0%)
| Volume | Unit Price | Shipment |
| 50g | 31 USD | Express |
| 500g | 154 USD | Express |
| 1Kg | 220 USD/Kg | Express |
| 20Kg | >20% cheaper | Express |
| 100Kg-Above | negotiable | Express / Sea |
The 2,3-dimethylpyrazine prices exhibit clear differentiation based on purity levels and intended applications. This premium positioning reflects the compound’s critical role in applications requiring stringent quality specifications. Market segmentation reveals distinct pricing tiers across product categories. Geographic distribution significantly influences pricing patterns and market development. The regional pricing structure reflects local market conditions, regulatory environments, and supply chain factors. North American and European markets typically demonstrate higher price points due to stringent quality standards and established distribution networks. Conversely, Asia-Pacific markets present competitive pricing opportunities while maintaining growth momentum through expanding industrial capacity.
Furthermore, the above 2,3-dimethylpyrazine price quotations do not include the express shipping fee. The reason is that the shipment cost of dimethylpyrazine may exceed the value of the sample. However, the bulk wholesale 2,3-dimethylpyrazine prices will be much lower than those of small orders. Please contact us for more details.
2,3-Dimethylpyrazine Specification
| Appearance: | Colorless to light yellow, clear liquid |
| Odor: | Nutty nut, coffee, caramellic roasted. |
| Purity (GC) | >=99% |
| Refractive Index (25°C) | 1.502 – 1.510 |
| Arsenic (mg/Kg) | <=3.0 |
| Heavy Metal (Pb, mg/Kg) | <=10.0 |
2,3-Dimethylpyrazine Uses
2,3-Dimethylpyrazine is an organic heterocyclic compound belonging to the pyrazine family, characterized by its distinctive nutty, roasted aroma profile. It has gained significant commercial importance across multiple industries.
Food and Beverage Uses
The most significant commercial application of 2,3-dimethylpyrazine lies within the food and beverage sector, where it serves as a crucial flavoring ingredient. The compound naturally occurs in roasted coffee beans, cocoa products, baked goods, and various nuts, contributing to their characteristic roasted flavor profiles.
Beverage Applications
In beverage formulation, 2,3-dimethylpyrazine serves multiple functional roles. Coffee-flavored beverages benefit significantly from their authentic roasted coffee notes, allowing formulators to enhance perceived coffee intensity without increasing caffeine content or coffee extract levels. The compound’s nutty characteristics make it valuable in nut-flavored beverages, where it provides depth and authenticity that cannot be achieved through nut extracts alone. Specialty beverage applications include chocolate drinks, where the cocoa notes of 2,3-dimethylpyrazine complement chocolate flavoring systems, and savory beverages, where its meaty undertones contribute to complex umami profiles.
Food Applications
The versatility of 2,3-dimethylpyrazine extends across numerous food categories. In snack food formulation, it enhances the roasted character of nuts, crackers, and chips, contributing to the overall satisfaction and perceived quality of these products.
Bakery applications benefit from its bread-crust and roasted grain characteristics, while sauce and soup formulations utilize its savory and meaty nuances to build complex flavor bases. The compound’s ability to enhance perceived richness makes it particularly valuable in reduced-fat formulations, where it can compensate for sensory losses associated with fat reduction.
Confectionery and Dessert Applications
In confectionery work, 2,3-dimethylpyrazine contributes authentic cocoa notes that enhance chocolate flavoring systems. Its nutty characteristics support praline, nougat, and nut-based confections, while its roasted notes complement caramel and toffee applications. The compound’s intensity means that minimal usage levels can achieve significant sensory impact, making it cost-effective for mass-production confectionery applications.
Fragrance Uses
Beyond food applications, 2,3-dimethylpyrazine finds use in the fragrance industry, where its warm, nutty character adds depth and complexity to perfume compositions. Perfumers incorporate it into oriental and gourmand fragrance families, where it provides a sophisticated base note that complements vanilla, amber, and woody elements. The cosmetic industry utilizes the compound in products designed to evoke comfort and warmth, such as body lotions, candles, and personal care items marketed with food-inspired scents. Its ability to create an immediate sensory association with familiar, pleasant aromas makes it valuable for products targeting emotional connections with consumers.
Chemical and Pharmaceutical Uses
In industrial settings, 2,3-dimethylpyrazine serves specialized functions beyond consumer products. The chemical industry uses it as an intermediate in the synthesis of more complex organic compounds, particularly in pharmaceutical research, where pyrazine derivatives show promise for various therapeutic applications. The compound also finds application in analytical chemistry as a standard reference material for gas chromatography and mass spectrometry analyses, particularly in studies involving food authenticity testing and flavor profiling research.
2,3-Dimethylpyrazine Benefits
2,3-dimethylpyrazine’s primary documented benefits center on its sensory properties for food and fragrance applications, while the broader pyrazine family shows promise for various therapeutic applications. Further specific research on 2,3-dimethylpyrazine’s biological activities would be valuable for understanding its full potential benefits. 2,3-Dimethylpyrazine offers significant commercial benefits across multiple industries through its distinctive aromatic properties, synthetic versatility, and established safety profile. Whether you are in food production, fragrance development, or chemical synthesis, 2,3-dimethylpyrazine is an essential compound that can elevate your products and processes.
The compound’s natural occurrence, combined with its proven commercial applications, positions it as a valuable ingredient for companies seeking to enhance product appeal, differentiate market offerings, and access growing opportunities in food, fragrance, pharmaceutical, and agricultural sectors. As markets continue to demand innovative solutions with natural credentials and proven performance, 2,3-Dimethylpyrazine represents a compelling choice for forward-thinking manufacturers and formulators.
2,3-Dimethylpyrazine Used in Flavour and Fragrance
2,3-dimethylpyrazine represents one of the most valuable tools in a flavorist’s palette for creating authentic roasted, nutty, and savory flavor profiles. As flavor formulation engineers, understanding the nuanced application of this powerful aroma chemical is essential for developing successful commercial products that meet consumer expectations for authentic taste experiences. The potency of 2,3-dimethylpyrazine cannot be overstated. Its extremely low odor threshold means that even minute quantities can significantly impact a formulation’s overall character. This intensity requires careful consideration during formulation, as overdosing can quickly overwhelm other flavor components and create an unbalanced profile.
A Coffee Flavor Essence
Includes the following ingredients (by weight):
Ethyl maltol, 3 parts; vanillin, 3 parts; phenylethyl alcohol, 1.5 parts; thiothiazole, 0.15 parts; furfural, 8 parts; furfuryl alcohol, 7.5 parts; 2-acetylpyrazine, 0.4 parts; 2,3-dimethylpyrazine, 0.35 parts; 2-ethyl 3,5/6-dimethylpyrazine, 0.2 parts; 2-ethyl 3-methylpyrazine, 3.75 parts; guaiacol, 9 parts; 2,3,5-trimethylpyrazine, 4 parts; isovaleraldehyde, 0.4 parts; acetic acid, 0.2 parts; furfuryl acetate, 0.3 parts; 2-acetylfuran, 0.5 parts; 2,6-dimethylfuran, 3.5 parts; propylene glycol, 54.25 parts.
In conclusion, 2,3-dimethylpyrazine represents a versatile and economically important compound whose applications span multiple industries. Its primary value lies in its ability to enhance and standardize flavor profiles in food products, though its utility extends to fragrance, cosmetic, and industrial applications. As a bulk 2,3-dimethylpyrazine manufacturer and supplier in China, we sell different grades of 2,3-dimethylpyrazine at wholesale prices to large manufacturers and small customers worldwide.