This section focuses on an overview of cis-3-hexenyl salicylate as well as its manufacturing processes and uses. Also, please check out the introduction to cis-3-hexenyl salicylate manufacturers, supply chain issues, cis-3-hexenyl salicylate suppliers, and cis-3-hexenyl salicylate prices. Sinofi can help you buy high-quality cis-3-hexenyl salicylate in bulk for your industry applications at wholesale prices based on FEMA 4750 and CAS 65405-77-8.
Table of Contents
What is Cis-3-Hexenyl Salicylate?
Cis-3-hexenyl salicylate, also known as leaf alcohol salicylate, is a synthetic fragrance compound that has become indispensable in modern perfumery and cosmetic formulations. Cis-3-hexenyl salicylate is similar to Ligustral. It has a distinctive fresh, green, and leafy aroma. This ester compound captures the essence of freshly cut grass and green leaves, making it a cornerstone ingredient for creating natural, outdoor-inspired fragrances. Cis-3-hexenyl salicylate is an ester formed through the combination of cis-3-hexenol (commonly known as leaf alcohol) and salicylic acid. Its structure features a six-carbon chain with a double bond in the cis configuration at the third carbon position, attached to a salicylate group. It represents the marriage between two important chemical families: the green alcohols that provide fresh, natural scents, and salicylic acid derivatives that offer stability and longevity to fragrance compositions. According to the Food and Agriculture Organization of the United Nations (FAO), cis-3-hexenyl salicylate is approved to be used in the food and flavour industries. It has also been evaluated by relevant regulatory authorities like EUR-Lex, ECHACHEM, NIST, and RIFM. The IFRA Transparency List provides a guideline to ensure the use of cis-3-hexenyl salicylate in the flavour, fragrance, personal care, and cosmetic industries.
Olfactory Characteristics
The scent profile of cis-3-hexenyl salicylate is what makes it particularly valuable in perfumery.
Primary Notes
- Fresh, green, and leafy aroma
- Reminiscent of freshly cut grass
- Clean, natural outdoor scent
- Subtle fruity undertones
Secondary Characteristics
- Good tenacity and longevity
- Blends well with other green notes
- Provides a natural, unprocessed quality to fragrances
- Acts as a bridge between the top and middle notes
The compound’s ability to evoke the sensation of being in a garden or natural outdoor environment has made it extremely popular in creating “green” fragrances, fresh colognes, and nature-inspired scent compositions. The compound is widely used as a fragrance ingredient in perfumes, colognes, and body care products, providing a pleasant aroma in cosmetic formulations such as lotions, creams, and soaps. It is also frequently used in scented candles to impart a green and leafy fragrance, adding a refreshing and outdoorsy note to the ambiance.
Regulatory Landscape
Cis-3-hexenyl salicylate has been included by the Council of Europe in the list of substances granted waiting status (COE No. 10685), and it appears in the JECFA (Joint FAO/WHO Expert Committee on Food Additives) database as a flavoring agent.
CAS No.: 65405-77-8
According to the American Chemical Society, the CAS number of cis-3-hexenyl salicylate is 65405-77-8.
CAS Name: Cis-3-Hexenyl Salicylate
Molecular Formula: C13H16O3
Molecular Mass: 220.26
Appearance: Colorless, clear, oily liquid.
Boiling Point: 394.00 °C. @ 760.00 mm Hg
Solubility: Soluble in alcohol but insoluble in water.
Other Names:
cis-3-Hexenyl salicylate
(3Z)-Hexenyl salicylate
cis-3-Hexen-1-yl salicylate
(Z)-3-Hexen-1-yl salicylate
Cis-3-Hexenyl Salicylate Odor
Odor Strength: Medium
Substantivity: 216 hours at 100.00 %
At 100.00 %. floral green metallic herbal balsam.
FEMA Number 4750
According to the Flavor and Extract Manufacturers Association (FEMA), the number of cis-3-hexenyl salicylate is FEMA 4750.
Bulk Cis-3-Hexenyl Salicylate Manufacturers
The bulk cis-3-hexenyl salicylate manufacturing is characterized by a mix of large multinational chemical companies and specialized chemical producers. Top cis-3-hexenyl salicylate manufacturers like Symrise and Mitsui contribute to a competitive landscape, driving innovation and supply chain optimization. Japanese chemical companies have established themselves as significant producers of green note fragrance chemicals, including cis-3-hexenol and related compounds. The industry’s focus on high-purity products, sustainable production methods, and regulatory compliance positions it well for continued growth.
Sinofi is a bulk manufacturer of cis-3-hexenyl salicylate in China, and we have a manufacturing facility with 2,500 square meters for the production of cis-3-hexenyl salicylate. We supply high-quality cis-3-hexenyl salicylate at bulk prices and serve flavour, fragrance, personal care, and cosmetic industries worldwide.
Manufacturing Process of Cis-3-Hexenyl Salicylate
Raw Materials and Precursors
The manufacturing of cis-3-hexenyl salicylate requires two primary raw materials.
Cis-3-hexenol (Leaf Alcohol)
This is the alcohol component, characterized by its green, grassy odor. Cis-3-hexenol can be obtained through several routes, including the reduction of cis-3-hexenal or through biotechnological processes using specific enzymes on linolenic acid.
Salicylic Acid
Commercial salicylic acid is typically produced through the Kolbe-Schmitt reaction from phenol and carbon dioxide.
Additional materials required for the manufacturing process include:
- Acid catalysts (such as sulfuric acid or p-toluenesulfonic acid)
- Organic solvents (toluene, dichloromethane, or similar)
- Dehydrating agents (molecular sieves or anhydrous sodium sulfate)
Manufacturing Process
The manufacturing of cis-3-hexenyl salicylate represents a well-established process in the flavor and fragrance industry.
Preparation and Pre-treatment
The manufacturing process begins with the careful preparation of raw materials. Both cis-3-hexenol and salicylic acid must be dried to remove any moisture content, as water can interfere with the esterification reaction and reduce yield. The alcohol component is typically dried using molecular sieves, while salicylic acid may be dried in a vacuum oven.
Esterification Reaction
The core manufacturing step involves a Fischer esterification reaction between cis-3-hexenol and salicylic acid. This reaction is typically carried out under the following conditions.
Reaction Setup
The reaction is conducted in a round-bottom flask equipped with a reflux condenser and Dean-Stark trap for water removal. The molar ratio of cis-3-hexenol to salicylic acid is typically maintained at 1.1:1.0 to ensure complete conversion of the acid.
Catalyst Addition
A small amount of acid catalyst (usually 1-3% by weight) is added to facilitate the reaction. Sulfuric acid or p-toluenesulfonic acid is a commonly used catalyst.
Reaction Conditions
The mixture is heated to approximately 120-140°C under reflux conditions. The reaction typically requires 4-8 hours for completion, with continuous removal of water formed during the reaction.
Monitoring
The progress of the reaction is monitored using gas chromatography (GC) or by measuring the acid value of the reaction mixture.
Success in the production of cis-3-hexenyl salicylate depends on careful control of reaction conditions, efficient purification methods, and rigorous quality control. As demand for natural and green fragrances continues to grow, the importance of this compound in commercial applications is expected to remain strong.
Bulk Cis-3-Hexenyl Salicylate Suppliers
The bulk supply of cis-3-hexenyl salicylate is dominated by several major players in the fragrance industry. Top cis-3-hexenyl salicylate suppliers like Symrise and Mitsui focus on integrating sensory expertise in fragrances, flavorings, cosmetic active ingredients, and raw materials and deliver high-quality aroma chemicals. They have developed many flavors and fragrances used in a wide variety of consumer products, including foods, beverages, personal care, and household products.
Sinofi is a bulk cis-3-hexenyl salicylate supplier in China, and we have a warehouse with 1,200 square meters for high-quality cis-3-hexenyl salicylate. We sell different grades of cis-3-hexenyl salicylate at wholesale prices to flavour, fragrance, personal care, and cosmetic manufacturers.
Supply Chain of Cis-3-Hexenyl Salicylate
The cis-3-hexenyl salicylate supply chain represents a sophisticated network of specialized manufacturers, distributors, and end-users spanning multiple continents.
Supply Chain Structure
Upstream Raw Materials
The supply chain for cis-3-hexenyl salicylate begins with Cis-3-hexenol and salicylic acid.
Manufacturing and Production Tier
Manufacturers (Global Leaders)
Major players include Symrise and Mitsui, contributing to a competitive landscape and driving innovation and supply chain optimization.
Manufacturers (Regional Players)
Regional players like companies in China and India also contribute significantly to the market.
Distribution and Supply Network
Primary Distribution Channels:
- Specialty chemical distributors
- Direct manufacturer sales
- Online platforms for smaller quantities
- Regional distributors and sales agents
Downstream Applications and End Markets
Primary Applications
The market segments by application include Fragrances, Personal Care Products, Household Products, and Industrial Applications. Main applications are Flavor and Fragrance, and Household Products.
Concentration Levels by Application
For high-end perfumes and fine fragrances, concentrations exceeding 10% are not uncommon, while in household products, concentrations may be significantly lower, often in the range of 0.1% to 1%.
End-User Industries
Key end-users include Cosmetics, Perfumery, Detergents, and Others.
Wholesale and Buy Cis-3-Hexenyl Salicylate in Bulk
Wholesale purchasing of cis-3-hexenyl salicylate offers significant advantages for companies requiring consistent access to this valuable aromatic compound. Success depends on careful supplier selection, proper storage and handling procedures, and strategic inventory management. By understanding the compound’s properties, applications, and market dynamics, cis-3-hexenyl salicylate buyers can make informed decisions that support both cost efficiency and product quality objectives. The growing market for natural and green fragrances suggests continued strong demand for cis-3-hexenyl salicylate, making it a strategic component for companies serving consumers who value authentic, nature-inspired scent experiences.
Benefits of Wholesale Purchasing
Cost Efficiency
Bulk purchasing of cis-3-Hexenyl salicylate offers significant economic advantages. Volume discounts can reduce per-unit costs by 15-40% compared to smaller quantity purchases, making it particularly attractive for manufacturers with consistent usage patterns.
Supply Chain Stability
Establishing wholesale relationships ensures reliable access to this specialized compound. Given its specific production requirements, having a steady supply chain prevents production delays and maintains product consistency.
Quality Assurance
Wholesale suppliers typically provide comprehensive documentation, including certificates of analysis, batch tracking information, and quality specifications that support regulatory compliance and quality control processes.
Supplier Selection Criteria
Technical Expertise
Choose suppliers who have demonstrated expertise in aromatic compounds and an understanding of the fragrance industry’s quality requirements. Technical support capabilities can prove invaluable for product development and troubleshooting.
Certification and Standards
Look for suppliers maintaining ISO certifications and other relevant quality standards. These certifications indicate a commitment to consistent quality and proper handling procedures.
As a bulk manufacturer and supplier of cis-3-hexenyl salicylate in China, we supply high-quality cis-3-hexenyl salicylate for the food, flavor, and fragrance industries. We also wholesale leaf hexanoate to small customers. Normally, they want to buy cis-3-hexenyl hexanoate in small quantities. To serve them, we can wholesale cis-3-hexenyl hexanoate at bulk prices and provide a one-stop purchasing service.
Cis-3-Hexenyl Salicylate Prices (USD/Kg)
Food Grade Cis-3-Hexenyl Salicylate Prices (FCC, GC Content >=97.0%)
| Volume | Unit Price | Shipment |
| 50g | 18 USD | Express |
| 500g | 91 USD | Express |
| 1Kg | 130 USD/Kg | Express |
| 20Kg | 20% cheaper | Express |
| 100Kg-Above | negotiable | Express / Sea |
The cis-3-hexenyl salicylate market demonstrates strong fundamentals with steady price appreciation supported by robust demand growth and limited supply flexibility. The compound’s versatility and the increasing awareness of fragrances’ role in enhancing consumer experience ensure its prominence in future fragrance and flavor developments. Higher purity grades of cis-3-hexenyl salicylate command premium prices due to enhanced performance characteristics and regulatory compliance requirements in fragrance applications. While price pressures from raw material costs and regulatory requirements persist, the premium nature of applications and growing demand for sustainable products support healthy pricing dynamics through 2033.
Furthermore, the above price quotations of cis-3-hexenyl salicylate, especially for small orders, do not include the express shipping fee. The reason is that the shipment cost of cis-3-hexenyl salicylate may exceed the value of the sample. However, the bulk wholesale prices of cis-3-hexenyl salicylate will be much lower than those of small orders. Please contact us for more details.
Cis-3-Hexenyl Salicylate Uses
Perfumery and Fine Fragrance Uses
Cis-3-hexenyl salicylate is a crucial component in modern perfumery, particularly for creating fresh, green, and natural-smelling compositions. Perfumers value this ingredient for its ability to:
- Provide top and middle notes that evoke the sensation of fresh vegetation.
- Enhance the naturalistic quality of floral fragrances.
- Create realistic garden and outdoor-themed scent profiles.
- Add complexity and depth to green accord compositions.
The compound is frequently found in perfumes designed to capture the essence of spring gardens, fresh meadows, and natural outdoor environments. Its versatility allows it to work harmoniously with floral notes like rose, jasmine, and lily of the valley, as well as with citrus and herbal components.
Consumer Product Fragrance
Beyond fine perfumery, cis-3-hexenyl salicylate plays a significant role in scenting various consumer products. Manufacturers incorporate this compound into:
- Household cleaning products provide a fresh, clean scent.
- Laundry detergents and fabric softeners for a garden-fresh appeal.
- Air fresheners and room sprays targeting natural fragrance preferences.
- Personal care products, including shampoos, body washes, and deodorants.
Cosmetic Uses
The cosmetic industry has embraced cis-3-hexenyl salicylate for its appealing fragrance properties and its compatibility with various formulation bases. Common applications include:
Skincare
The compound is often incorporated into skincare formulations where a fresh, natural scent is desired. Its use in creams, lotions, and serums helps mask any unpleasant odors from active ingredients while providing a pleasant sensory experience during application.
Hair Care
Shampoos, conditioners, and styling products frequently contain cis-3-hexenyl salicylate to impart a fresh, clean fragrance that consumers associate with healthy, vibrant hair. The compound’s green notes complement the natural associations with plant-based hair care.
Flavor Uses
While primarily known for its fragrance applications, cis-3-hexenyl salicylate also finds limited use in the flavor industry. Its green, slightly fruity taste profile makes it suitable for:
- Enhancing natural flavors in beverages.
- Contributing to complex fruit flavor profiles.
- Adding freshness to certain food products (in very small concentrations).
Regulatory approval and safety assessments are crucial when considering flavor applications, as the compound must meet strict food-grade standards.
As consumer preferences continue to favor fresh, natural-smelling products, the importance of this compound in creating appealing sensory experiences is likely to grow. The ongoing development of new applications and improved formulation techniques will likely expand the utility of cis-3-hexenyl salicylate, making it an increasingly important tool for product developers seeking to meet evolving consumer demands for natural, fresh, and appealing fragrances in their daily products.
Cis-3-Hexenyl Salicylate Benefits
Fragrance Enhancement Benefits
The most prominent benefit of cis-3-hexenyl salicylate is its ability to impart a distinctive green, fresh fragrance note. This makes it an excellent choice for:
- Green floral compositions: Adding depth and complexity to floral fragrances.
- Fresh and clean formulations: Enhancing the perception of cleanliness in personal care products.
- Natural-inspired scents: Creating fragrances that mimic outdoor and botanical environments.
- Top note enhancement: Providing immediate fresh impact in fragrance compositions.
UV Protection Benefits
As a salicylate derivative, cis-3-hexenyl salicylate offers mild UV-filtering capabilities. While not a primary sunscreen agent, it can contribute to the overall UV protection profile of cosmetic formulations, particularly in:
- Light protection cosmetics.
- Daily moisturizers with SPF enhancement.
- Hair care products require UV protection.
- Color cosmetics with sun protection benefits.
Antimicrobial Benefits
The salicylate component of the molecule contributes to mild antimicrobial properties, which can be beneficial in:
- Preservative systems for cosmetic products.
- Formulations requiring extended shelf life.
- Personal care products are prone to microbial contamination.
- Natural and organic formulations seeking gentle preservation.
Skin Conditioning Benefits
Cis-3-hexenyl salicylate can provide mild skin conditioning effects, including:
- Gentle exfoliation: The salicylate component offers very mild keratolytic properties.
- Skin smoothing: Helping to improve skin texture and appearance.
- Enhanced penetration: Potentially improving the absorption of other active ingredients.
- Soothing effects: Providing gentle skin comfort in sensitive formulations.
Cis-3-hexenyl salicylate represents a valuable ingredient in modern cosmetic and fragrance formulations, offering a unique combination of sensory and functional benefits. Its fresh, green fragrance profile, combined with mild UV protection and skin conditioning properties, makes it an attractive choice for formulators seeking to create products that deliver both immediate sensory appeal and long-term benefits.
Cis-3-Hexenyl Salicylate Used in Flavour and Fragrance
A Long-Lasting Fragrance Essence
Include the following ingredients (Unit: Kg):
Limonene, 3.2; vanillyl alcohol, 1; phenylethyl alcohol, 15.1; geraniol 980, 1.6; linalool, 3.7; rose oxide, 1; helional, 1; methyl hexylcinnamaldehyde, 2.7; lyral, 10.2; ethyl acetate, 0.9; cis-3-hexenyl salicylate, 1.1; amyl salicylate, 8.2; benzyl acetate, 0.9; methyl dihydrojasmonate, 12.3; linalyl acetate, 1.2; ethyl 2-trans-4-cis-decadienoate, 0.21; lemon oil, 0.55; patchouli oil, 1.7.
Blender: Cis-3-hexenol, 0.03; eugenol, 0.07; ambroxol, 0.22; delta damascone, 0.22; damascenone, 0.13; phenethyl phenylacetate, 0.21; ethyl caproate, 0.11; ambrettolid, 0.58; gamma-undecanolactone, 0.04; bergamot oil, 0.11; Egyptian geranium oil, 0.03; Sri Lanka cinnamon oil, 0.03; orris butter, 0.015. Mix and compound.
Modifier: isoeugenol methyl ether, 0.03; decanal, 0.05; citral, 0.11; trans-2-hexenal, 0.06; raspberry ketone, 0.06; dimethylbenzyl acetate, 0.015; allyl heptanoate, 0.09; isoamyl acetate, 0.09; prenyl acetate, 0.06; o-tert-butyl cyclohexyl acetate, 0.07; nerol acetate, 0.05; butyl acetate, 0.09; basil oil, 0.015. Mix and compound.
Fixative: galaxol, 26.5; synthetic oak moss, 0.11. Mix and compound.
Solvent: dipropylene glycol, 4.299.
In conclusion, cis-3-hexenyl salicylate has established itself as a versatile and valuable ingredient across multiple industries. Its unique ability to provide authentic green, leafy notes makes it indispensable in modern fragrance formulation, while its technical properties ensure reliable performance in diverse applications. As a bulk manufacturer and supplier of cis-3-hexenyl salicylate in China, we sell different grades of cis-3-hexenyl salicylate at wholesale prices to large manufacturers and small customers worldwide.