This section provides an overview of 2-methoxy-3-methylpyrazine, covering its manufacturing processes, applications, and regulatory status. Also, please check out the introduction to 2-methoxy-3-methylpyrazine manufacturers, supply chain issues, 2-methoxy-3-methylpyrazine suppliers, and 2-methoxy-3-methylpyrazine prices. Sinofi can help you buy high-quality 2-methoxy-3-methylpyrazine in bulk for your industry applications at wholesale prices based on FEMA 3183 and CAS 2847-30-5.
Table of Contents
What is 2-Methoxy-3-Methylpyrazine?
2-Methoxy-3-methylpyrazine represents a significant compound in the modern flavour formulator’s palette. This heterocyclic aromatic compound, characterized by its distinctive hazelnut, almond, and peanut-like aroma profile, serves as a critical ingredient in the production of natural and nature-identical flavouring systems. 2-Methoxy-3-methylpyrazine reveals a relatively simple structure consisting of a pyrazine ring substituted with both a methoxy group at position 2 and a methyl group at position 3. This specific substitution pattern creates unique sensory properties that distinguish it from other pyrazine derivatives. These structural features contribute to its relatively low odor threshold, typically measured in parts per billion in aqueous solutions, making it an exceptionally powerful flavouring agent that requires careful handling and precise dosing during formulation work. According to the U.S. Food and Drug Administration (FDA), 2-methoxy-3-methylpyrazine is approved to be used in the flavour and fragrance industries.
Regulatory Considerations and Safety
2-Methoxy-3-methylpyrazine has been evaluated by various food safety authorities like JECFA, EFSA, RIFM, ECHACHEM, NIST, EUR-Lex, and WHO. It is generally recognized as safe for use in food, flavour, and fragrance applications when used at appropriate levels. The compound appears on approved flavouring substance lists in major markets, including the United States, European Union, and Japan, though specific use levels and application restrictions may vary by jurisdiction. Formulators must maintain awareness of regional regulatory requirements and ensure compliance with local food additive regulations. The fragrance standard of 2-methoxy-3-methylpyrazine has been set by organizations such as IFRA.
Natural Occurrence
2-Methoxy-3-methylpyrazine occurs naturally in various food sources, including roasted coffee beans, cocoa products, and certain nuts. This natural presence supports its acceptance as a flavouring ingredient and provides validation for its use in food applications. The compound forms during thermal processing of foods, particularly during roasting and heating processes that involve amino acids and reducing sugars.
Sensory Profile and Characteristics
The organoleptic properties of 2-methoxy-3-methylpyrazine encompass a complex range of descriptors that make it particularly valuable in creating authentic flavour experiences. The compound exhibits predominantly earthy, nutty, and roasted characteristics with distinct vegetable-like nuances. Flavour professionals often describe its profile as having hazelnut, almond, and peanut notes, accompanied by subtle green and raw potato undertones.
What makes this compound particularly interesting from a formulation perspective is its ability to contribute depth and complexity to flavour systems without dominating the overall profile when used at appropriate levels. The earthy and nutty characteristics it imparts can serve as excellent bridging notes between top and base notes in complex flavour compositions, creating a more rounded and authentic sensory experience.
CAS No.: 2847-30-5
According to the American Chemical Society, the CAS number of 2-methoxy-3-methylpyrazine is 2847-30-5.
CAS Name: 2-Methoxy-3-Methylpyrazine
Molecular Formula: C6H8N2O
Molecular Mass: 124.14
Appearance: Colorless to light yellow, clear liquid
JECFA Number: 788
Boiling Point: 158.00 to 159.00 °C. @ 760.00 mm Hg
Solubility: Soluble in alcohol and organic solvents. Soluble in water (8457 mg/L @ 25 °C).
Other Names:
♦ Pyrazine, 2-methoxy-3-methyl-
♦ 2-Methoxy-3-methylpyrazine
♦ 2-Methyl-3-methoxypyrazine
♦ 3-Methoxy-2-methylpyrazine
2-Methoxy-3-Methylpyrazine Odor
Odor Description: At 0.10% in dipropylene glycol, roasted almond, hazelnut peanut.
FEMA Number 3183
According to the Flavour and Extract Manufacturers Association (FEMA), the 2-methoxy-3-methylpyrazine FEMA number is 3183.
Bulk 2-Methoxy-3-Methylpyrazine Manufacturers
The bulk manufacturing of 2-methoxy-3-methylpyrazine comprises both large multinational flavour and fragrance companies and specialized chemical manufacturers. Top 2-methoxy-3-methylpyrazine manufacturers like Ernesto Ventos and Firmenich focus specifically on pyrazine compounds and related heterocyclic chemicals.
Sinofi is a bulk 2-methoxy-3-methylpyrazine manufacturer in China, and we have a manufacturing facility with 2,500 square meters for the production of 2-methoxy-3-methylpyrazine. We supply high-quality 2-methoxy-3-methylpyrazine at bulk prices and serve global clients in the food, flavour, and fragrance sectors.
Manufacturing Process of 2-Methoxy-3-Methylpyrazine
The manufacturing of 2-methoxy-3-methylpyrazine requires a careful balance of synthetic efficiency, product quality, and economic viability.
Primary Synthetic Route: Direct Methylation and Methoxylation
The most economically viable manufacturing process involves sequential functionalization of the pyrazine core. The process typically begins with commercially available 3-methylpyrazine as the starting material.
The initial step involves selective methoxylation at the 2-position through nucleophilic aromatic substitution. This reaction employs sodium methoxide in methanol under controlled temperature conditions, typically ranging from 60-80°C. The reaction requires careful pH control to ensure selectivity and minimize side product formation.
The process utilizes a continuous stirred-tank reactor configuration with precise temperature control and inert atmosphere maintenance. Reaction monitoring through gas chromatography ensures optimal conversion rates while minimizing over-reaction.
Alternative Synthetic Approaches
A secondary manufacturing route involves the cyclization of appropriate dicarbonyl precursors with suitable nitrogen sources. This method utilizes 1-methoxy-2-oxobutane and appropriate diamines under acidic conditions to form the pyrazine ring directly with the desired substitution pattern.
This cyclization approach offers advantages in terms of raw material availability but requires more stringent reaction conditions and typically results in lower overall yields compared to the direct functionalization method.
Bulk 2-Methoxy-3-Methylpyrazine Suppliers
The global supply for 2-methoxy-3-methylpyrazine demonstrates significant concentration in Asia, particularly China, which has emerged as the dominant manufacturing hub. Top 2-methoxy-3-methylpyrazine suppliers like Ernesto Ventos and Firmenich have plants in China. This concentration reflects China’s broader role in the specialty chemicals sector and its established infrastructure for flavour and fragrance ingredient production.
Sinofi is a bulk 2-methoxy-3-methylpyrazine supplier in China, and we have a warehouse with 1,200 square meters for high-quality 2-methoxy-(3,5 or 6)-methylpyrazine. We sell different grades of 2-methoxy-3-methylpyrazine at wholesale prices to food, flavour, and fragrance manufacturers.
Supply Chain of 2-Methoxy-3-Methylpyrazine
The supply chain of 2-methoxy-3-methylpyrazine represents a mature but evolving market structure characterized by geographical concentration, technological innovation, and increasing regulatory complexity.
Supply Chain Structure Analysis
Raw Material Suppliers
The supply chain foundation begins with chemical precursors required for pyrazine synthesis.
Manufacturing and Production
Primary manufacturing capabilities demonstrate clear geographical clustering in China, Europe, and North America.
Distribution and Logistics
The distribution landscape for 2-methoxy-3-methylpyrazine is anchored by direct relationships between specialty chemical manufacturers and large-scale flavour houses. Major global producers maintain direct sales channels to serve multinational flavour and fragrance companies that require consistent, high-volume supplies with guaranteed specifications. The secondary distribution tier consists of specialized chemical distributors who serve as intermediaries between manufacturers and smaller flavour houses, food ingredient suppliers, and regional processors. These distributors provide essential value-added services, including inventory management, regulatory documentation support, and technical consultation.
End-User Applications
Primary demand originates from several key sectors like food and beverage, fragrance, and pharmaceutical industries.
Wholesale and Buy 2-Methoxy-3-Methylpyrazine in Bulk
Successful wholesale procurement of 2-methoxy-3-methylpyrazine requires a systematic approach encompassing comprehensive supplier evaluation, rigorous quality specification development, and proactive risk management. Purchasing managers should establish clear procurement procedures addressing technical requirements, commercial terms, and quality assurance protocols.
Wholesale Procurement Considerations
Volume Requirements and Economic Order Quantities
When establishing wholesale procurement strategies for 2-methoxy-3-methylpyrazine, buyers must carefully evaluate their organization’s consumption patterns. The compound’s potency means that modest quantities often satisfy extensive production schedules. Successful procurement strategies typically involve establishing annual volume commitments that balance inventory carrying costs against potential supply disruptions. Leading 2-methoxy-3-methylpyrazine suppliers typically offer volume-based pricing tiers, with significant cost advantages becoming apparent at higher order quantities. Organizations should conduct thorough demand forecasting to identify optimal order volumes that minimize the total cost of ownership while maintaining adequate safety stock levels.
Quality Specifications and Technical Standards
The compound maintains purity levels of 98% or higher in commercial grades, representing the industry standard for food and fragrance applications. Purchasing managers must establish comprehensive technical specifications that address purity requirements, moisture content limitations, heavy metals restrictions, and microbiological standards aligned with intended end-use applications.
Supplier Evaluation and Vendor Management
The global supply base for 2-methoxy-3-methylpyrazine includes specialized aroma chemical manufacturers and distributors across multiple geographic regions. Purchasing managers should prioritize suppliers demonstrating consistent quality management systems, established regulatory expertise, and proven track records in serving similar industry applications.
Geographic diversification strategies help mitigate supply chain risks while potentially reducing transportation costs.
As a bulk manufacturer and supplier of 2-methoxy-3-methylpyrazine in China, we supply high-quality 2-methoxy-3-methylpyrazine for the food, flavour, and fragrance industries. We also wholesale 2-methoxy-(3,5 or 6)-methylpyrazine to small customers. Normally, they want to buy 2-methoxy-3-methylpyrazine in small quantities. To serve them, we can wholesale 2-methoxy-3-methylpyrazine at bulk prices and provide a one-stop purchasing service.
2-Methoxy-3-Methylpyrazine Prices (USD/Kg)
Food Grade 2-Methoxy-3-Methylpyrazine Prices (GC Content >=99.0%)
| Volume | Unit Price | Shipment |
| 50g | 72 USD | Express |
| 500g | 364 USD | Express |
| 1Kg | 520 USD/Kg | Express |
| 20Kg | >20% cheaper | Express |
| 100Kg-Above | negotiable | Express / Sea |
The 2-methoxy-3-methylpyrazine market operates within a dynamic and growing industry environment characterized by robust demand fundamentals and evolving consumer preferences toward natural and premium flavouring solutions. While pricing pressures persist due to raw material costs and supply chain challenges, the compound’s essential role in flavour enhancement applications across multiple industries ensures sustained market relevance and growth potential. 2-Methoxy-3-methylpyrazine prices remain commercially sensitive. Industry analysis reveals several key pricing influences.
Raw Material Cost Pressures
Chemical manufacturers have experienced an average price increase of 3.5% per year over the last decade, which impacts the pyrazine market.
Quality and Purity Premiums
High-purity grades (minimum 99% assay) command premium pricing, particularly for food-grade applications requiring compliance with international safety standards.
Furthermore, the above price quotations of 2-methoxy-3-methylpyrazine do not include the express shipping fee. The reason is that the shipment cost may exceed the value of the sample. However, the bulk wholesale prices of 2-methoxy-3-methylpyrazine will be much lower than those of small orders. Please contact us for more details.
2-Methoxy-3-Methylpyrazine Specification
| Appearance: | Colorless to light yellow, clear liquid |
| Odor: | Roasted hazelnut, almond, and peanut odor |
| Purity (GC) | >=99% |
| Refractive Index (20°C) | 1.505 – 1.510 |
2-Methoxy-3-Methylpyrazine Uses
Flavour and Fragrance Applications
The most significant commercial application of 2-methoxy-3-methylpyrazine lies within the flavour and fragrance sector. The compound exhibits a characteristic nutty, roasted, and slightly sweet aroma profile that makes it particularly valuable for creating complex flavour compositions. Food manufacturers incorporate this compound to enhance the sensory appeal of various products, particularly those requiring nutty or roasted flavour notes.
In the fragrance industry, 2-methoxy-3-methylpyrazine serves as a key ingredient in creating sophisticated scent profiles. Perfumers utilize its unique olfactory characteristics to add depth and complexity to fragrance formulations, particularly in compositions that aim to evoke warmth, comfort, or gourmand qualities.
Food Industry Applications
Within food manufacturing, 2-methoxy-3-methylpyrazine finds extensive use in flavouring systems for baked goods, confectionery products, and savory applications. The compound’s ability to impart roasted and nutty characteristics makes it particularly suitable for chocolate products, coffee-flavoured items, and nut-based confections. Additionally, it enhances the flavour profiles of processed foods where Maillard reaction flavours are desired but may be technically challenging to achieve through traditional cooking methods.
The compound also plays a role in creating meat flavouring systems, where its roasted characteristics contribute to the overall savory profile that consumers associate with properly cooked proteins. This application extends to plant-based meat alternatives, where manufacturers seek to replicate the complex flavour profiles of traditional meat products.
Technical Properties and Advantages
The effectiveness of 2-methoxy-3-methylpyrazine in these applications stems from several key technical properties. Its volatility characteristics allow for proper aroma release while maintaining stability during processing and storage. The compound demonstrates good solubility in both polar and non-polar solvents, facilitating its incorporation into diverse formulation systems. Furthermore, the compound exhibits thermal stability that allows it to withstand typical food processing temperatures without significant degradation. This property ensures consistent flavour delivery in applications that involve heating, baking, or other thermal processing steps.
2-Methoxy-3-Methylpyrazine Benefits
Beyond food applications, 2-methoxy-3-methylpyrazine offers benefits in the fragrance industry, where its aromatic properties contribute to the development of complex scent profiles. Its chemical stability and compatibility with other ingredients make it valuable for formulators seeking to create distinctive product characteristics. The compound’s consistent performance and reliable supply chain support its adoption across various industrial applications, providing manufacturers with a dependable ingredient for their formulations.
2-Methoxy-3-Methylpyrazine Used in Flavour and Fragrance
2-Methoxy-3-methylpyrazine finds extensive application in savory flavour systems, particularly those designed to replicate or enhance roasted, baked, or cooked food profiles. The compound serves as an effective building block in meat flavouring systems, where its earthy and nutty characteristics contribute to the complexity associated with cooked protein products.
In baked goods applications, this pyrazine enhances the perception of toasted grain flavours and contributes to the overall richness of bread, cracker, and cereal flavouring systems. The compound works synergistically with other pyrazines and Maillard reaction products to create authentic baked flavour profiles.
Coffee and cocoa flavour systems benefit significantly from the inclusion of 2-methoxy-3-methylpyrazine, where it reinforces the roasted character while adding depth to the overall flavour profile. In these applications, the compound helps bridge the gap between raw ingredient flavours and the complex notes developed during roasting processes.
Technical Formulation Considerations
From a formulation perspective, 2-methoxy-3-methylpyrazine demonstrates good solubility in both polar and non-polar carrier systems, though optimal dispersion may require careful consideration of the specific application matrix. In oil-based systems, the compound distributes readily, while in aqueous systems, proper emulsification or encapsulation techniques may enhance stability and flavour release.
The compound exhibits moderate to good stability under standard storage conditions, though protection from light and excessive heat extends shelf life. In finished products, the compound shows good retention through typical manufacturing processes, including pasteurization and moderate heat treatments.
Interaction studies indicate that 2-methoxy-3-methylpyrazine works harmoniously with other pyrazines, thiazoles, and furan compounds commonly found in savory flavour systems. However, careful balance is required as the compound can dominate lighter flavour notes if used in excessive concentrations.
Formulation Guidelines and Best Practices
Effective utilization of 2-methoxy-3-methylpyrazine requires careful attention to concentration levels, typically ranging from 0.1 to 10 parts per million, depending on the specific application and desired intensity. Initial trials should begin with conservative levels, as the compound’s impact can be substantial even at low concentrations. The compound performs optimally when incorporated early in the formulation process, allowing adequate time for equilibration with other flavour components. In complex systems containing multiple pyrazines, sequential addition and evaluation help achieve optimal balance and prevent any single component from overwhelming the overall profile.
Temperature considerations during formulation and storage significantly impact the compound’s performance. Maintaining moderate temperatures during blending and storage preserves the compound’s integrity while ensuring consistent flavour delivery in finished products.
Successful application of this compound requires understanding its sensory properties, technical limitations, and optimal usage conditions. When properly incorporated into flavour systems, 2-methoxy-3-methylpyrazine contributes significantly to the development of sophisticated, appealing flavour profiles that meet contemporary consumer expectations for authentic taste experiences.
A Coffee Essence with the Freshly Roasted Flavour
Include the following ingredients (Total 10 Kg, unit: Kg):
Benzyl Alcohol, 0.014; Furfurylthiol, 0.001; Acetoin, 0.002; Terpinen-4-Ol, 0.027; Butyric Acid, 0.11; Ethyl Formate, 0.002; Ethyl Acetate, 0.08; Isovaleraldehyde, 0.011; Furfural, 0.2; 5-Methylfurfural, 0.12; Butanedione, 0.037; 2,3-Pentanedione, 0.028; 3,4-Dimethyl-1,2-Cyclopentanedione, 0.036; 2,6-Dimethoxybenzene, 0.10; 3,4-Dimethylphenol, 0.05; Dimethyl Sulfide, 0.002; Vanillin, 0.058; 2,3,5 Trimethylpyrazine, 0.03; Acetylpyrazine, 0.003; 2-Methoxy-3-Methylpyrazine, 0.027; 2-Ethyl-3, (5 Or 6)-Dimethylpyrazine, 0.041; 4-Vinylguaiacol 10% Pg, 0.08; Furanone, 0.072; Triacetin, 8.869.
In conclusion, 2-methoxy-3-methylpyrazine represents a valuable compound for the food and fragrance industries, offering distinct aromatic properties and reliable performance characteristics. As a bulk manufacturer and supplier of 2-methoxy-3-methylpyrazine in China, we sell different grades of methoxy methylpyrazine at wholesale prices to large manufacturers and small customers worldwide.