This section provides an overview of 2-methoxy-3-isopropylpyrazine (bean pyrazine), covering its manufacturing processes, applications, and regulatory status. Also, please check out the introduction to 2-methoxy-3-isopropylpyrazine manufacturers, supply chain issues, 2-methoxy-3-isopropylpyrazine suppliers, and 2-methoxy-3-isopropylpyrazine prices. Sinofi can help you buy 2-methoxy-3-isopropylpyrazine in bulk for industry applications at wholesale prices based on FEMA 3358 and 2-methoxy-(3 or 5 or 6)-isopropylpyrazine (CAS 93905-03-4), 2-methoxy-3-isopropylpyrazine (25773-40-4).
Table of Contents
What is 2-Methoxy-3-Isopropylpyrazine (Bean Pyrazine)?
2-Methoxy-3-isopropylpyrazine, also named bean pyrazine, represents a significant compound in the flavour and fragrance industry’s arsenal of nature-identical aroma chemicals. It belongs to a specialized class of heterocyclic compounds that have revolutionized our ability to recreate authentic vegetable and green bean flavour profiles in commercial formulations. 2-Methoxy-3-isopropylpyrazine features a pyrazine ring core with two key substituents: a methoxy group at position 2 and an isopropyl group at position 3. 2-Methoxy-(3 or 5 or 6)-isopropylpyrazine is a mixture of 2-isopropyl-3-methoxypyrazine and 2-isopropyl-5-methoxypyrazine, and 2-isopropyl-6-methoxypyrazine. This molecule exemplifies the structural elegance that characterizes many potent flavour compounds. According to the U.S. Food and Drug Administration (FDA), 2-methoxy-3-isopropylpyrazine is approved to be used in the food, flavour, and fragrance industries.
Regulatory Considerations and Safety
2-Methoxy-3-isopropylpyrazine has been evaluated by various food safety authorities like JECFA, EFSA, RIFM, ECHACHEM, NIST, and WHO. The compound maintains approval for use in flavouring applications across major regulatory jurisdictions, though specific concentration limits and application restrictions vary by region. In the United States, it falls under the category of flavouring substances generally recognized as safe (GRAS) when used in accordance with good manufacturing practices. The European Union similarly permits its use as a flavouring substance, subject to quantum satis principles. Formulation professionals must remain cognizant of the maximum use levels established by regulatory bodies and industry organizations such as FEMA. Documentation of usage levels and careful batch record maintenance are essential for regulatory compliance and quality assurance purposes. The fragrance standard of bean pyrazine has been set by organizations such as IFRA.
Natural Occurrence
2-Methoxy-3-isopropylpyrazine occurs naturally in various agricultural products, particularly bell peppers, pea beans, and select vegetable varieties. This natural presence provides manufacturers with opportunities to leverage clean-label positioning and meet consumer preferences for naturally derived ingredients. The compound’s occurrence in food sources establishes a foundation for regulatory acceptance and consumer familiarity.
Sensory Characteristics
The sensory profile of 2-methoxy-3-isopropylpyrazine is dominated by green vegetative notes reminiscent of fresh bell pepper, pea bean, and raw vegetables. At threshold concentrations, the compound delivers a distinctly vegetal character with subtle earthy undertones. The isopropyl substitution contributes a slight minty-cooling sensation, while the methoxy group moderates the intensity compared to unsubstituted pyrazines. Detection thresholds vary significantly across applications, typically ranging from 0.1 to 2.0 parts per billion in aqueous systems. The compound exhibits excellent tenacity, providing lasting green notes that can persist throughout the flavour release profile. However, overdosing can quickly lead to undesirable, harsh, or medicinal off-notes, requiring precise dosing control during formulation.
CAS No.: 93905-03-4 and 25773-40-4
According to the American Chemical Society, the CAS numbers of 2-methoxy-3-isopropylpyrazine and 2-methoxy-(3 or 5 or 6)-isopropylpyrazine are 25773-40-4 and 93905-03-4, respectively.
CAS Name: 2-Methoxy-3-Isopropylpyrazine
Molecular Formula: C8H12N2O
Molecular Mass: 152.19
Appearance: Colorless to light yellow, clear liquid
JECFA Number: 790
Boiling Point: 189.00 to 190.00 °C. @ 760.00 mm Hg
Solubility: Soluble in organic solvents. Insoluble in water (698.6 mg/L @ 25 °C).
Other Names:
♦ Pyrazine, 2-isopropyl-3-methoxy-
♦ 2-Methoxy-3-(1-methylethyl)pyrazine
♦ 2-Methoxy-3-isopropylpyrazine
♦ 2-Isopropyl-3-methoxypyrazine
♦ 3-Isopropyl-2-methoxypyrazine
♦ 2-Methoxy-(3 or 5 or 6)-isopropylpyrazine
2-Methoxy-3-Isopropylpyrazine Odor
Odor Description: At 0.10 % in dipropylene glycol, green bean, earthy, green pepper odor.
FEMA Number 3358
According to the Flavour and Extract Manufacturers Association (FEMA), the FEMA number of 2-methoxy-3-isopropylpyrazine and 2-methoxy-(3 or 5 or 6)-isopropylpyrazine is 3358.
Bulk 2-Methoxy-3-Isopropylpyrazine Manufacturers
The bulk 2-methoxy-3-isopropylpyrazine production includes several established flavour, fragrance, and chemical manufacturers operating across different market segments. Top 2-methoxy-3-isopropylpyrazine manufacturers like Givaudan and Sigma-Aldrich specialize in this market segment, providing technical support and customized solutions for food and beverage manufacturers.
Sinofi is a bulk 2-methoxy-3-isopropylpyrazine manufacturer in China, and we have a manufacturing facility with 2,500 square meters for the production of bean pyrazine. We supply high-quality 2-methoxy-3-isopropylpyrazine at bulk prices and serve global clients in the food, flavour, and fragrance industries.
Manufacturing Process of 2-Methoxy-3-Isopropylpyrazine
Direct Alkylation Method
The most commercially viable approach involves the selective alkylation of 2-methoxy-3-chloropyrazine with isopropyl-containing nucleophiles. This method utilizes 2-methoxypyrazine as the starting material, which undergoes halogenation at the 3-position using phosphorus oxychloride or similar chlorinating agents under controlled temperature conditions ranging from 80-120°C. The subsequent nucleophilic substitution employs isopropylmagnesium bromide or isopropyl lithium reagents in the presence of suitable catalysts such as palladium complexes or nickel-based systems. The reaction typically proceeds under inert atmosphere conditions with temperatures maintained between 60-100°C to optimize yield while minimizing side product formation.
Condensation Approach
An alternative synthetic strategy involves the direct condensation of appropriately substituted precursors. This method begins with the preparation of 2-methoxy-3-isopropyl-1,4-diketone intermediates, followed by cyclization with diamines under acidic or basic conditions. The process requires precise pH control and temperature management throughout the reaction sequence to ensure optimal ring closure and prevent decomposition of sensitive intermediates.
Bulk 2-Methoxy-3-Isopropylpyrazine Suppliers
The bulk 2-methoxy-3-isopropylpyrazine supply demonstrates characteristics of a stable specialty chemical segment with diverse supplier options and established end-use applications. Top 2-methoxy-3-isopropylpyrazine suppliers like Givaudan and Sigma-Aldrich provide bulk quantities in various packaging formats. They offer flexible packaging solutions to accommodate different customer requirements.
Sinofi is a bulk 2-methoxy-3-isopropylpyrazine supplier in China, and we have a warehouse with 1,200 square meters for high-quality bean pyrazine. We sell different grades of 2-methoxy-3-isopropylpyrazine at wholesale prices to food, flavour, and fragrance manufacturers.
Supply Chain of 2-Methoxy-3-Isopropylpyrazine
The 2-methoxy-3-isopropylpyrazine supply chain demonstrates the characteristic complexity of specialized chemical markets, with distinct upstream, midstream, and downstream segments serving diverse end-user applications.
Supply Chain Structure Analysis
Raw Materials and Basic Chemicals
The upstream supply chain begins with basic pyrazine production. Raw material procurement focuses on fundamental chemical precursors, including pyrazine itself and methoxy-containing intermediates.
2-Methoxy-3-Isopropylpyrazine Manufacturing
The midstream segment encompasses specialized pyrazine manufacturers capable of producing methoxylated pyrazine derivatives through controlled synthesis processes.
Distribution and End-User Applications
The downstream segment encompasses flavour houses, fragrance companies, and direct industrial users seeking pyrazine derivatives for product formulation. Distribution channels include direct manufacturer sales, specialty chemical distributors, and integrated flavour and fragrance corporations.
Wholesale and Buy 2-Methoxy-3-Isopropylpyrazine in Bulk
Successful wholesale procurement of 2-methoxy-3-isopropylpyrazine requires cross-functional collaboration between purchasing, quality assurance, and technical teams. Bean pyrazine buyers should establish clear communication protocols and decision-making frameworks and ensure efficient procurement processes while maintaining product quality standards. Building strong supplier relationships through transparent communication and partnership approaches creates mutual value and supports long-term success.
Supplier Evaluation and Selection Criteria
Quality certifications represent the foundation of supplier evaluation, with industry-specific certifications serving as baseline requirements. Bean pyrazine suppliers must demonstrate consistent analytical capabilities, maintaining detailed certificates of analysis for each batch.
Quality Assurance and Technical Specifications
Bulk purchasing requires rigorous quality control protocols to ensure consistent product performance. Standard specifications of 2-methoxy-3-isopropylpyrazine typically include purity levels exceeding 98%, with defined limits for residual solvents, heavy metals, and microbial contamination. Sensory evaluation protocols should complement analytical testing to verify organoleptic properties match specification requirements.
Cost Management and Pricing Strategies
Bulk procurement of bean pyrazine enables significant cost advantages through volume pricing structures. Establishing annual or multi-year contracts with committed volumes typically secures preferential pricing while providing budget predictability. However, bean pyrazine buyers must balance volume commitments against inventory carrying costs and product shelf life considerations.
As a bulk manufacturer and supplier of 2-methoxy-3-isopropylpyrazine in China, we supply 2-methoxy-3-isopropylpyrazine for the food, flavour, and fragrance industries. We also wholesale it to small customers. Normally, they want to buy bean pyrazine in small quantities. To serve them, we can wholesale 2-methoxy-3-isopropylpyrazine at bulk prices and provide a one-stop purchasing service.
2-Methoxy-3-Isopropylpyrazine Prices (USD/Kg)
Food Grade 2-Methoxy-3-Isopropylpyrazine Prices (GC Content >=99.0%)
| Volume | Unit Price | Shipment |
| 50g | 210 USD | Express |
| 500g | 1050 USD | Express |
| 1Kg | 1500 USD/Kg | Express |
| 20Kg | >20% cheaper | Express |
| 100Kg-Above | negotiable | Express / Sea |
The 2-methoxy-3-isopropylpyrazine pricing reflects its position within the specialty chemicals market, where quality, purity, and regulatory compliance command premium valuations. Current market pricing varies significantly based on purity levels, with high-purity variants (98-99%) commanding substantial premiums over lower-grade materials. The pricing structure of bean pyrazine reflects the specialized manufacturing processes required to produce consistent, food-grade materials meeting regulatory requirements across different jurisdictions.
Market Growth Drivers and Demand Factors
Several fundamental factors drive sustained demand growth for 2-methoxy-3-isopropylpyrazine, creating favorable conditions for price advancement. The growth of the food and beverage sector plays a crucial role in driving demand for pyrazines, as these compounds are widely used as flavouring agents and aroma enhancers. Consumer preferences increasingly favor natural and clean-label ingredients, supporting demand for naturally-derived pyrazine compounds. This preference shift creates pricing differentiation opportunities for manufacturers offering natural extraction processes and certified organic products.
Furthermore, the above price quotations of 2-methoxy-3-isopropylpyrazine do not include the express shipping fee. The reason is that the shipment cost may exceed the value of the sample. However, the bulk wholesale prices of 2-methoxy-3-isopropylpyrazine will be much lower than those of small orders. Please contact us for more details.
2-Methoxy-3-Isopropylpyrazine Specification
| Appearance: | Colorless to light yellow, clear liquid |
| Odor: | Green pea bean, earthy, green pepper odor |
| Purity (GC) | >=98% |
| Refractive Index (20°C) | 1.492 – 1.495 |
2-Methoxy-3-Isopropylpyrazine Uses
2-Methoxy-3-isopropylpyrazine represents a significant compound within the pyrazine family, serving crucial roles across multiple industrial sectors.
Vegetable and Savory Applications
2-Methoxy-3-isopropylpyrazine serves as an authentic green note contributor in vegetable flavours, particularly those targeting bell pepper, cucumber, and fresh herb profiles. Its natural occurrence in various vegetables makes it valuable for creating realistic vegetable bouillons, soups, and seasoning blends. Typical usage levels range from 0.05 to 0.5 ppm in finished food products.
Beverage Systems
In beverage applications, this pyrazine adds complexity to vegetable juice blends and provides the fresh green notes essential in certain cocktail mixers and specialty sodas. Its water solubility characteristics require careful pH and ionic strength considerations to maintain stability throughout product shelf life.
Processed Food Enhancement
The compound proves particularly effective in enhancing the authenticity of processed vegetable products where natural green notes may be diminished through thermal processing. Applications include frozen vegetables, canned goods, and dehydrated vegetable preparations.
Fragrance Applications
While primarily utilized in flavour systems, 2-methoxy-3-isopropylpyrazine finds selective use in fragrance formulations targeting fresh, green accords. Its vegetative character complements other green notes such as hexenyl acetate and leaf alcohols in creating realistic garden-fresh compositions. Usage levels in fragrance remain considerably lower than flavour applications, typically under 0.1% of the total fragrance concentrate.
Technical Properties and Advantages
The compound demonstrates excellent thermal stability, allowing it to maintain its aromatic characteristics during food processing and manufacturing operations. This stability ensures consistent flavour delivery in finished products regardless of processing conditions. Additionally, the compound exhibits good solubility characteristics in both aqueous and organic systems, facilitating its incorporation into diverse formulation matrices. This versatility enables manufacturers to use the compound across different product formats and delivery systems without compromising performance.
2-Methoxy-3-Isopropylpyrazine Benefits
The molecular structure of 2-methoxy-3-isopropylpyrazine provides several technical benefits for formulators. Its relatively high potency means effective dosage levels remain economically viable, while its chemical stability supports consistent product performance. The compound demonstrates compatibility with various carrier systems and shows favorable solubility characteristics in both aqueous and lipophilic formulations.
2-Methoxy-3-Isopropylpyrazine Used in Flavour and Fragrance
The primary application domain for 2-methoxy-3-isopropylpyrazine encompasses savory flavour systems where authentic vegetable notes are desired. The compound finds extensive use in formulations for soups, sauces, and prepared foods requiring genuine bell pepper or mixed vegetable character. Its inclusion in meat flavour systems can enhance the perception of freshness and add depth to the overall profile. In beverage applications, particularly in vegetable juice formulations, this pyrazine serves as a critical component for achieving authentic taste profiles. The compound’s ability to bridge the gap between processed and fresh vegetable flavours makes it invaluable in applications where thermal processing might otherwise compromise natural flavour integrity.
The versatility of 2-methoxy-3-isopropylpyrazine extends to its synergistic effects with other flavour components. When combined with appropriate aliphatic aldehydes and alcohols, it can create remarkably authentic cucumber or fresh-cut grass notes. Its interaction with sulfur-containing compounds can yield complex savory profiles suitable for meat and umami-rich applications.
Formulation Guidelines and Technical Considerations
Working with 2-methoxy-3-isopropylpyrazine demands sophisticated technical expertise and appropriate laboratory infrastructure. The compound’s extreme potency necessitates the preparation of serial dilutions, typically beginning with concentrations of 0.1% or lower in appropriate solvents such as propylene glycol or triacetin. Direct handling of the concentrated material should be minimized to prevent contamination of work areas and inadvertent flavour carry-over.
Stability Factors
The compound demonstrates good stability under neutral pH conditions but may undergo degradation in strongly acidic or basic environments. Exposure to elevated temperatures during processing should be carefully monitored, as thermal degradation can lead to the formation of undesirable off-notes. Interaction with oxidizing agents should be avoided to maintain flavour integrity throughout the product’s shelf life.
The selection of appropriate carrier systems and encapsulation technologies can significantly enhance the performance of 2-methoxy-3-isopropylpyrazine in finished products. Microencapsulation techniques can provide controlled release properties while protecting the compound from degradation during processing and storage.
The compound demonstrates good thermal stability under typical food processing conditions but shows sensitivity to strong alkaline environments. pH levels above 8.0 may lead to degradation and off-note development. Storage under refrigerated conditions in amber glass containers helps preserve sensory quality and extends shelf life.
Compatibility and Interactions
2-Methoxy-3-isopropylpyrazine exhibits excellent compatibility with most common flavour ingredients. However, formulation engineers should exercise caution when combining with other potent pyrazines, as additive effects can quickly exceed taste thresholds. The compound pairs particularly well with complementary green notes and citrus modifiers that enhance its fresh character.
As consumer preferences continue evolving toward more natural and authentic flavour experiences, compounds like 2-methoxy-3-isopropylpyrazine that deliver genuine sensory impressions will remain essential components in sophisticated formulation strategies.
A Chili Essence
Include the following ingredients (Total 100 Kg, unit: Kg):
2-methylpyrazine, 0.03; 2.3-dimethylpyrazine, 0.01; 2.3.5-trimethylpyrazine, 0.01; 4-methylthiazole, 0.005; 2-isobutylthiazole, 0.001; 4.5-dimethylthiazole, 0.001; benzothiazole, 0.019; 2-acetylfuran, 0.03; 2.5-dimethylfuran, 0.04; glacial acetic acid, 0.012; lactic acid, 0.013; hexaldehyde, 0.005; leaf aldehyde, 0.0005; 2.4-heptadienal, 0.01; 2-methoxy-(3/5/6)-isopropylpyrazine, 0.02; 2-Isobutyl-3-Methoxypyrazine, 0.02; gamma-hexalactone, 0.04; propyl propyl ester, 0.03; furanone, 0.4; furanone acetate, 0.5; ethyl maltol, 1.2; capsicum oleoresin, 6; capsicum extract oil is added to make up to 100.
In conclusion, 2-methoxy-3-isopropylpyrazine represents a valuable tool in the modern flavour and fragrance formulator’s palette, offering authentic green vegetative notes with excellent technical performance characteristics. As a bulk manufacturer and supplier of bean pyrazine in China, we sell different grades of 2-methoxy-3-isopropylpyrazine at wholesale prices to large manufacturers and small customers worldwide.