This section focuses on an overview of dihydroactinidiolide (Tealactone) as well as its manufacturing processes and uses. Also, please check out the introduction to dihydroactinidiolide manufacturers, supply chain issues, dihydroactinidiolide suppliers, and dihydroactinidiolide prices. Sinofi can help you buy high-quality dihydroactinidiolide in bulk for your industry applications at wholesale prices based on FEMA 4020, (-)-Dihydroactinidiolide, CAS 17092-92-1, and CAS 15356-74-8, (±)-Dihydroactinidiolide.
Table of Contents
What is Dihydroactinidiolide (Tealactone)?
Dihydroactinidiolide, also named Tealactone, is a volatile terpene with a sweet, tea-like odor that serves as both a natural fragrance compound and a synthetic chemical intermediate. This versatile compound occurs naturally in black tea and tobacco, while also being produced synthetically for commercial applications. It represents an important naturally occurring compound that has garnered significant attention across multiple industries, particularly in the fragrance, food, and pharmaceutical sectors. This bicyclic sesquiterpene derivative serves as both a valuable flavoring agent and a potential therapeutic compound. It belongs to the class of organic compounds known as sesquiterpene lactones. Dihydroactinidiolide features a distinctive bicyclic structure consisting of a six-membered ring fused to a five-membered lactone ring. This molecular architecture contributes to its stability and unique sensory properties. According to the U.S. Food and Drug Administration (FDA), dihydroactinidiolide is approved to be used in the cigarette, food, pharmaceutical, flavour, and fragrance industries.
Dihydroactinidiolide has been evaluated for safety in food and cosmetic applications by various regulatory bodies like JECFA, EUR-LEX, ECHA CHEM, NIST, and WHO. The compound is generally recognized as safe for use in flavors and fragrances when used at appropriate concentrations. Dihydroactinidiolide is generally recognized as safe (GRAS) for use in food applications within specified concentration limits. The fragrance industry follows guidelines established by the International Fragrance Association (IFRA) to ensure safe use in food, flavour, personal care, and household products.
Natural Occurrence and Biosynthesis
Dihydroactinidiolide occurs widely in nature as a result of carotenoid degradation processes. Carotenoids, the pigments responsible for yellow, orange, and red colors in many plants, undergo enzymatic and non-enzymatic breakdown to produce various aroma compounds, including dihydroactinidiolide. This degradation can occur during plant maturation, processing, fermentation, or storage.
The compound has been identified in numerous natural sources. Tea represents one of the most significant sources, where dihydroactinidiolide contributes to the characteristic aroma of both black and green tea varieties. It forms during the withering and fermentation processes that tea leaves undergo during processing. Tobacco is another major source, where the compound develops during curing and aging processes. Additionally, dihydroactinidiolide has been detected in various fruits, particularly those rich in carotenoids such as apricots and passion fruit, as well as in some wines, where it contributes to bouquet complexity.
Sensory Characteristics and Applications
From a sensory perspective, dihydroactinidiolide possesses distinctive aromatic properties that make it valuable in flavor and fragrance formulations. The compound exhibits a sweet, fruity, and slightly tea-like aroma with woody undertones. Its odor threshold is relatively low, meaning that even small amounts can significantly impact the overall aroma profile of a product. This characteristic makes it an efficient and cost-effective ingredient in various applications.
The fragrance industry utilizes dihydroactinidiolide as a component in perfume compositions, where it serves as a modifier that adds depth and complexity to floral and fruity accords. Its ability to blend well with other fragrance materials and its stability make it particularly useful in creating long-lasting scent profiles. In the flavor industry, the compound finds application in tea flavors, tobacco products, and fruit flavor compositions, where it helps recreate or enhance natural taste profiles.
CAS No.: 17092-92-1 or 15356-74-8
According to the American Chemical Society, the CAS numbers of (-)-Dihydroactinidiolide and (±)-Dihydroactinidiolide are 17092-92-1 and 15356-74-8, respectively.
CAS Name: (-)-Dihydroactinidiolide, (±)-Dihydroactinidiolide.
Molecular Formula: C11H16O2
Molecular Mass: 180.24
Appearance: White crystalline powder or colorless, clear liquid.
Melting Point: 40-41 °C
Boiling Point: 199.00 °C. @ 760.00 mm Hg
Solubility: Soluble in alcohol. Slightly soluble in water (600.6 mg/L @ 25 °C)
Other Names:
♦ Actinidiolide, dihydro-
♦ Dihydroactinidiolide
♦ (-)-Dihydroactinidiolide
♦ (R)-Dihydroactinidiolide
♦ 5,6,7,7a-tetrahydro-4,4,7a-trimethylbenzofuran-2(4H)-one
Dihydroactinidiolide Odor
Odor Strength: Medium
Substantivity: 298 hours at 100.00 %
At 100.00 %. ripe apricot, fruity plum, berry grape, tropical fruit, woody.
FEMA Number 4020
According to the Flavor and Extract Manufacturers Association (FEMA), the number of dihydroactinidiolide is FEMA 4020.
Bulk Dihydroactinidiolide Manufacturers
The bulk dihydroactinidiolide production is dominated by manufacturers concentrated in China and Europe. Top dihydroactinidiolide manufacturers like Mane typically offer products meeting various quality specifications. The Asian market, particularly China, represents a significant portion of global dihydroactinidiolide production. They operate under strict quality control requirements, particularly for fragrance and pharmaceutical research applications. Chinese dihydroactinidiolide manufacturers dominate production capacity and offer competitive pricing, while international manufacturers provide specialized services and regulatory compliance advantages.
Sinofi is a bulk dihydroactinidiolide manufacturer in China, and we have a manufacturing facility with 2,500 square meters for the production of dihydroactinidiolide. We supply high-quality dihydroactinidiolide at bulk prices and serve the cigarette, food, pharmaceutical, flavour, and fragrance industries worldwide.
Manufacturing Process of Dihydroactinidiolide
Synthetic Manufacturing Process
Raw Material
β-Ionone or Citral.
β-ionone or citral is selected as the starting material, ozonation reaction or low temperature cyclization reaction is selected to prepare β-cyclocitral, the prepared β-cyclocitral solution is subjected to Darzen condensation reaction to obtain β-cyclohomocitral, a catalyst, p-chloroperbenzoic acid or m-chloroperbenzoic acid is added to the chloroform solution of β-cyclohomocitral for catalytic reaction, and the product is collected from the reaction mixture to obtain the target product dihydroactinolide.
Natural Extraction Process
Dihydroactinidiolide can be formed from β-Carotene by treatment with polyphenoloxidase, lipoxygenase, and xanthine oxidase, highlighting the compound’s importance in both natural extraction and biotechnological production processes. The primary natural source of dihydroactinidiolide is tobacco leaves, where it occurs as a significant aroma component. The extraction process typically involves several key steps:
Steam Distillation
Fresh or cured tobacco leaves undergo steam distillation to obtain essential oils containing dihydroactinidiolide. This process requires careful temperature control to prevent thermal degradation of the target compound. The distillation typically operates at temperatures between 100-120°C under atmospheric pressure.
Solvent Extraction
Alternative extraction methods employ organic solvents such as hexane or ethyl acetate to extract the compound from plant material. This approach often yields higher concentrations but requires subsequent purification steps to remove solvent residues and other extracted compounds.
Chromatographic Purification
The crude extract undergoes column chromatography using silica gel as the stationary phase. The separation process utilizes gradient elution with increasingly polar solvent systems to isolate dihydroactinidiolide from other components.
The manufacturing of dihydroactinidiolide encompasses diverse production methodologies, each presenting unique advantages and challenges. Chemical synthesis routes offer established processes with predictable yields, while biotechnological approaches provide sustainability benefits and potential for producing naturally labeled products. As demand for this valuable aroma compound continues to grow, manufacturers must balance economic considerations with environmental responsibility and regulatory compliance.
Bulk Dihydroactinidiolide Suppliers
The bulk dihydroactinidiolide supply market reflects broader industry trends toward natural ingredients and enhanced quality standards. Top dihydroactinidiolide suppliers like Mane and some Chinese companies provide comprehensive coverage for diverse industrial requirements. Chinese dihydroactinidiolide suppliers represent the largest segment of the market, offering competitive pricing and high quality.
Sinofi is a bulk dihydroactinidiolide supplier in China, and we have a warehouse with 1,200 square meters for high-quality dihydroactinidiolide. We sell different grades of dihydroactinidiolide at wholesale prices to cigarette, food, pharmaceutical, flavour, and fragrance manufacturers.
Supply Chain of Dihydroactinidiolide
The dihydroactinidiolide supply chain functions within the dynamic flavors and fragrances sector, which serves diverse end-use industries including cigarettes, food, pharmaceuticals, personal care, cosmetics, and household products.
Supply Chain Structure
Raw Materials and Primary Production
The dihydroactinidiolide supply chain begins with two primary upstream sources: natural extraction and synthetic production. Natural sources include agricultural products such as tea leaves, tobacco, fenugreek, and various fruits. These raw materials are subject to seasonal variations, climate conditions, and biotechnology that can significantly impact supply stability and pricing.
Manufacturing and Processing
The midstream segment encompasses specialized chemical manufacturers and fragrance houses that process raw materials into finished dihydroactinidiolide products. Manufacturing facilities typically maintain strict quality control standards to ensure product consistency and regulatory compliance. Professional suppliers ensure their materials comply with IFRA and EU 1223/2009 regulations for safety and quality, reflecting the industry’s commitment to regulatory adherence.
Distribution and End-Use Applications
The downstream segment of dihydroactinidiolide consists of distributors, formulators, and end-use manufacturers across multiple industries.
Success in this market requires a sophisticated understanding of upstream supply sources, midstream processing capabilities, and downstream market requirements.
Wholesale and Buy Dihydroactinidiolide in Bulk
The wholesale procurement of dihydroactinidiolide represents a strategic decision requiring careful evaluation of quality requirements, supplier capabilities, and operational considerations. By understanding the complexities involved in bulk purchasing and establishing robust supplier relationships, companies can secure reliable access to this valuable ingredient while optimizing costs and maintaining quality standards. As the fragrance and flavor industry continues to evolve, those who master the intricacies of wholesale procurement will find themselves well-positioned to capitalize on emerging opportunities in this dynamic market.
Wholesale Purchasing Advantages
- The decision to purchase dihydroactinidiolide in bulk quantities reflects several strategic considerations that extend beyond simple cost savings. While economies of scale certainly play a role, with bulk purchases typically offering per-unit costs 30-50% lower than small-volume orders, the advantages of wholesale procurement encompass broader operational benefits.
- Supply chain reliability represents a critical factor for manufacturers dependent on consistent access to specialty chemicals. By establishing wholesale purchasing agreements, companies can secure steady inventory levels and protect against market volatility. This approach proves particularly valuable given the specialized nature of dihydroactinidiolide production, which involves relatively few qualified manufacturers globally.
- Furthermore, wholesale relationships often provide access to technical support and customization options not available to smaller buyers. Leading suppliers frequently offer consultation services on formulation optimization, regulatory compliance assistance, and even custom synthesis variations to meet specific application requirements.
As a bulk dihydroactinidiolide manufacturer and supplier in China, we supply high-quality ingredients for the cigarette, food, pharmaceutical, flavour, and fragrance industries. We also wholesale dihydroactinidiolide to small customers. Normally, they want to buy dihydroactinidiolide in small quantities. To serve them, we can wholesale dihydroactinidiolide at bulk prices and provide a one-stop purchasing service.
Dihydroactinidiolide Prices (USD/Kg)
Food Grade Dihydroactinidiolide Prices (GC Content >=99.0%, sum of isomers)
| Volume | Unit Price | Shipment |
| 50g | 168 USD | Express |
| 500g | 840 USD | Express |
| 1Kg | 1200 USD/Kg | Express |
| 10Kg | 20% cheaper | Express |
| 100Kg-Above | negotiable | Express / Sea |
The dihydroactinidiolide prices vary significantly based on quantity, purity, and intended application. Natural extraction from plant sources involves complex processes that contribute to higher costs, while synthetic production offers more consistent pricing but requires significant initial investment in specialized equipment and expertise. Dihydroactinidiolide pricing reflects its position as a specialty chemical straddling multiple high-value industries.
Dihydroactinidiolide Pricing Factors
- Growing consumer preference for natural and naturally-derived fragrance ingredients.
- Increasing applications in niche and artisanal perfumery.
- Rising demand from emerging markets.
- Technological advances are enabling new extraction and synthesis methods.
Furthermore, the above dihydroactinidiolide price quotations do not include the express shipping fee. The reason is that the shipment cost of dihydroactinidiolide may exceed the value of the sample. However, the bulk wholesale prices of dihydroactinidiolide will be much lower than those of small orders. Please contact us for more details.
Dihydroactinidiolide Uses
Dihydroactinidiolide represents a significant compound in the modern fragrance and flavor industry, with emerging applications in various scientific fields.
Fragrance Uses
The fragrance industry has embraced dihydroactinidiolide as a valuable component in perfume formulations. The compound exhibits a unique olfactory profile characterized by sweet, fruity, and slightly tea-like notes with subtle woody undertones. Perfumers particularly value its ability to enhance the longevity and depth of fragrances while contributing a natural, sophisticated character to compositions.
In fine fragrance creation, dihydroactinidiolide serves multiple functions. It acts as an excellent fixative, helping to stabilize volatile top notes and extend the overall wear time of perfumes. Additionally, the compound harmonizes well with both floral and woody accords, making it particularly useful in creating complex, multi-faceted fragrances that evolve gracefully on the skin.
Flavor Uses
The food and beverage industry utilizes dihydroactinidiolide to enhance and modify flavor profiles in various products. Its presence in tea and tobacco has made it particularly valuable in recreating authentic taste experiences in flavored products. The compound contributes to the characteristic aged notes in certain alcoholic beverages and helps develop the complex flavor profiles sought after in premium tea blends.
Food technologists have found that dihydroactinidiolide can effectively mask undesirable flavors while enhancing perceived freshness and quality. This dual functionality makes it particularly valuable in product reformulations aimed at reducing sugar or salt content without compromising taste satisfaction.
Pharmaceutical Uses
Beyond fragrance uses, dihydroactinidiolide demonstrates significant biological activity. It has antioxidant activity and an anticancer effect. These properties drive demand in pharmaceutical research, where pricing reflects the compound’s potential therapeutic value.
Cosmetic Uses
The cosmetic industry has shown increasing interest in dihydroactinidiolide for its potential skin-conditioning properties. Some formulations incorporate the compound not only for its pleasant scent but also for its possible contribution to product stability and skin feel.
Agricultural and Plant Biology Uses
In plant biology, dihydroactinidiolide serves as a potent plant growth inhibitor and plays a crucial role in gene expression regulation. Research has identified its involvement in photo-acclimation processes in Arabidopsis, demonstrating its importance in plant adaptation to light conditions. This regulatory function suggests potential applications in agricultural biotechnology, where controlled plant growth and development are essential considerations.
Dihydroactinidiolide Benefits
Health and Therapeutic Benefits
Recent scientific research has revealed that dihydroactinidiolide possesses multiple therapeutic properties that make it particularly valuable for health applications. The compound exhibits significant antioxidant activity, helping to neutralize harmful free radicals in biological systems. This antioxidant capacity extends to its demonstrated ability to scavenge DPPH radicals and nitric oxide, suggesting potential applications in preventing oxidative stress-related conditions.
Perhaps most notably, dihydroactinidiolide shows promise in neuroprotection. Research has demonstrated its effectiveness against amyloid-beta-induced toxicity in neuronal cells, a finding with significant implications for neurodegenerative disease research. The compound acts as a potent acetylcholinesterase inhibitor with an impressive IC50 value of 34.03 nanomolar, suggesting potential applications in conditions affecting cognitive function. Furthermore, studies indicate that dihydroactinidiolide can increase cell viability in amyloid-beta-treated neuronal cells by reducing reactive oxygen species generation, providing a protective effect against neurodegeneration.
The compound also demonstrates antibacterial and anticancer activities, expanding its potential therapeutic applications. These properties, combined with favorable absorption, distribution, metabolism, and excretion profiles, position dihydroactinidiolide as a promising candidate for pharmaceutical development.
Dihydroactinidiolide Used in Flavour and Fragrance
An Oolong Tea Type Tobacco Flavour
Include the following ingredients (by weight, %):
Dimethyl sulfide, 0.15; isobutylaldehyde, 0.15; acetic acid, 0.225; isovaleraldehyde, 0.12; isoamyl alcohol, 0.15; butyric acid, 0.075; 2-methylpyrazine, 0.225; 2,5-dimethylpyrazine, 1.5; 2,3,5-trimethylpyrazine, 0.3; phenylacetaldehyde, 0.12; 2-acetylpyrrole, 0.15; octanol, 0.09; 2-ethyl-3,5-dimethylpyrazine, 0.075; linalool, 0.45; maltol, 1 .5; phenylethanol, 0.098; indole, 0.0294; benzyl acetate, 0.294; D,L-menthol, 0.049; ethyl maltol, 0.98; linalyl acetate, 0.098; 4-methyl-5-hydroxyethylthiazole, 0.049; anisyl alcohol, 0.049; cis-3-hexenyl hexanoate, 0.196; alpha-ionone, 0.0294; dihydroactinidiolide, 0.294; delta-dodecalactone, 0.147; methyl palmitate, 0.49; oolong tea extract, 19.6; propylene glycol, 72.3172.
In conclusion, dihydroactinidiolide exemplifies the valuable contributions that natural compounds make to modern industry. Its presence in everyday products from perfumes to beverages demonstrates the ongoing relevance of naturally-derived ingredients in meeting consumer needs. As a bulk dihydroactinidiolide manufacturer and supplier in China, we sell different grades of dihydroactinidiolide at wholesale prices to large manufacturers and small customers worldwide.